Results 1 to 10 of about 22,486 (204)

ARF: the most misunderstood GTPase I ever knew - why study ARF GAPs. [PDF]

Front Mol Biosci
ADP-ribosylation factors (ARFs) are GTP-binding proteins that were discovered in the early 1980s, shortly after heterotrimeric GTP-binding proteins (G proteins) and nearly simultaneously with RAS.
Turn RE, Dacks JB, Rosenberg EM, Soubias O, Northup JK, Randazzo PA.   +5 more
europepmc   +2 more sources

Nucleotide exchange-dependent and nucleotide exchange-independent functions of plant heterotrimeric GTP-binding proteins. [PDF]

Sci Signal, 2019
G protein α subunits in Arabidopsis can function independently of guanine nucleotide exchange.
Maruta N, Trusov Y, Chakravorty D, Urano D, Assmann SM, Botella JR.   +5 more
europepmc   +5 more sources

Roles of Heterotrimeric GTP-Binding Proteins in the Progression of Heart Failure

Journal of Pharmacological Sciences, 2011
.: Heart failure is a major cause of death in developed countries, and the development of an epoch-making cure is desired from the viewpoint for improving the quality of life and reducing the medical cost of the patient.
Motohiro Nishida
doaj   +4 more sources

Activation of phospholipase C beta4 by heterotrimeric GTP-binding proteins [PDF]

Journal of Biological Chemistry, 1994
Transient transfection assays were used to determine how the activity of phospholipase C beta 4, which is preferentially expressed in retina, was regulated.
Jiang, Huiping, Simon, Melvin I., Wu, Dianqing   +2 more
core   +3 more sources

Characterization of the GTPγS release function of a G protein-coupled receptor. [PDF]

Nat Commun
G protein-coupled receptor (GPCR) signaling is one of the most ubiquitous and sensitive forms of cell surface reception. GPCRs stabilize the nucleotide-free state of heterotrimeric guanine-nucleotide binding proteins (G proteins); however, this state is ...
Bohn LM, Stahl EL.
europepmc   +2 more sources

Influence of expression and purification protocols on Gα biochemical activity: kinetics of plant and mammalian G protein cycles. [PDF]

Front Mol Biosci
Heterotrimeric G proteins, composed of Gα, Gβ, and Gγ subunits, are a class of signal transduction complexes with broad roles in human health and agriculturally relevant plant physiological and developmental traits.
Gookin TE, Chakravorty D, Assmann SM.
europepmc   +2 more sources

Structural comparison of unconventional G protein YchF with heterotrimeric G protein and small G protein

Plant Signaling & Behavior, 2022
Guanine nucleotide-binding (G) proteins, namely, phosphate-binding (P) loop GTPases, play a critical role in life processes among different species. Based on the structural characteristics, G proteins can be divided into heterotrimeric G proteins, small ...
Maozhen Luo, Zhiwei Han, Guoye Huang, Rongfang Li, Yi Liu, Junjie Lu, Lin Liu, Rui Miao   +7 more
doaj   +1 more source

Interaction of Prokineticin Receptors with Accessory Proteins

Encyclopedia, 2023
G protein-coupled receptors (GPCRs) are transmembrane proteins that mediate the intracellular pathway of signals not only through heterotrimeric GTP-binding proteins (G proteins) but also through their associations with a variety of additional partner ...
Roberta Lattanzi, Rossella Miele
doaj   +1 more source

Pediatric Encephalopathy: Clinical, Biochemical and Cellular Insights into the Role of Gln52 of GNAO1 and GNAI1 for the Dominant Disease

Cells, 2021
Heterotrimeric G proteins are immediate transducers of G protein-coupled receptors—the biggest receptor family in metazoans—and play innumerate functions in health and disease. A set of de novo point mutations in GNAO1 and GNAI1, the genes encoding the α-
Gonzalo P. Solis, Tatyana V. Kozhanova, Alexey Koval, Svetlana S. Zhilina, Tatyana I. Mescheryakova, Aleksandr A. Abramov, Evgeny V. Ishmuratov, Ekaterina S. Bolshakova, Karina V. Osipova, Sergey O. Ayvazyan, Sébastien Lebon, Ilya V. Kanivets, Denis V. Pyankov, Sabina Troccaz, Denis N. Silachev, Nikolay N. Zavadenko, Andrey G. Prityko, Vladimir L. Katanaev   +17 more
doaj   +1 more source

G protein activation without a GEF in the plant kingdom. [PDF]

PLoS Genetics, 2012
Animal heterotrimeric G proteins are activated by guanine nucleotide exchange factors (GEF), typically seven transmembrane receptors that trigger GDP release and subsequent GTP binding.
Daisuke Urano, Janice C Jones, Hao Wang, Melissa Matthews, William Bradford, Jeffrey L Bennetzen, Alan M Jones   +6 more
doaj   +1 more source