Results 1 to 10 of about 11,723 (175)
Roles of Heterotrimeric GTP-Binding Proteins in the Progression of Heart Failure
Journal of Pharmacological Sciences, 2011 .: Heart failure is a major cause of death in developed countries, and the development of an epoch-making cure is desired from the viewpoint for improving the quality of life and reducing the medical cost of the patient.
Motohiro Nishida
doaj +5 more sources
Nucleotide exchange-dependent and nucleotide exchange-independent functions of plant heterotrimeric GTP-binding proteins. [PDF]
Sci Signal, 2019 G protein α subunits in Arabidopsis can function independently of guanine nucleotide exchange.
Maruta N +5 more
europepmc +8 more sources
FEBS Letters, 1995 Heterotrimeric G proteins are involved in hormonal signal transduction across the plasma membrane. Recent evidence suggests that they have a role in vesicular protein transport as well. Biochemical probes that interfere with the classical G protein cycle have been applied to the field of intracellular membrane transport to study their mechanism of ...
J Bernd Helms
exaly +5 more sources
ARF: the most misunderstood GTPase I ever knew - why study ARF GAPs [PDF]
Frontiers in Molecular BiosciencesADP-ribosylation factors (ARFs) are GTP-binding proteins that were discovered in the early 1980s, shortly after heterotrimeric GTP-binding proteins (G proteins) and nearly simultaneously with RAS.
Rachel E. Turn +5 more
doaj +2 more sources
Interaction of Prokineticin Receptors with Accessory Proteins [PDF]
Encyclopedia, 2023 G protein-coupled receptors (GPCRs) are transmembrane proteins that mediate the intracellular pathway of signals not only through heterotrimeric GTP-binding proteins (G proteins) but also through their associations with a variety of additional partner ...
Roberta Lattanzi, Rossella Miele
doaj +2 more sources
Heterotrimeric G Protein–RasGAP Coupling Drives Adaptation During Chemotaxis [PDF]
CellsChemotaxis enables eukaryotic cells to detect and migrate along extracellular chemoattractant gradients spanning several orders of magnitude. This remarkable dynamic range relies on adaptation, a process that allows cells to reset their signaling ...
Xuehua Xu +4 more
doaj +2 more sources
Heterotrimeric and Unconventional GTP Binding Proteins in Plant Cell Signaling [PDF]
Plant Cell, 2002 Signal-transducing GTPases in plants include small G proteins, heterotrimeric G proteins, and, potentially, several unique types of GTP binding proteins that are not members of either of the aforementioned classes.
Sarah M Assmann, Assmann Sarah M
exaly +3 more sources
Characterization of the GTPγS release function of a G protein-coupled receptor [PDF]
Nature CommunicationsG protein-coupled receptor (GPCR) signaling is one of the most ubiquitous and sensitive forms of cell surface reception. GPCRs stabilize the nucleotide-free state of heterotrimeric guanine-nucleotide binding proteins (G proteins); however, this state is ...
Laura M. Bohn, Edward L. Stahl
doaj +2 more sources
Influence of expression and purification protocols on Gα biochemical activity: kinetics of plant and mammalian G protein cycles [PDF]
Frontiers in Molecular BiosciencesHeterotrimeric G proteins, composed of Gα, Gβ, and Gγ subunits, are a class of signal transduction complexes with broad roles in human health and agriculturally relevant plant physiological and developmental traits.
Timothy E. Gookin +2 more
doaj +2 more sources
Plant Signaling & Behavior, 2022 Guanine nucleotide-binding (G) proteins, namely, phosphate-binding (P) loop GTPases, play a critical role in life processes among different species. Based on the structural characteristics, G proteins can be divided into heterotrimeric G proteins, small ...
Maozhen Luo +7 more
doaj +1 more source