Role of heterotrimeric Gα proteins in maize development and enhancement of agronomic traits. [PDF]
Plant shoot systems derive from the shoot apical meristems (SAMs), pools of stems cells that are regulated by a feedback between the WUSCHEL (WUS) homeobox protein and CLAVATA (CLV) peptides and receptors.
Qingyu Wu +3 more
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The association of heterotrimeric GTP-binding protein (Go) with microtubules
The heterotrimeric GTP-binding regulatory proteins (G proteins) play an important role in the regulation of membrane signal transduction. Recently, we identified the association of Go protein with mitotic spindles. Here we have investigated the relationship between Go protein and microtubules. We used temperature-dependent reversible assembly and taxol
H C, Wu, C Y, Chiu, P H, Huang, C T, Lin
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Control of striatal signaling by G protein regulators
Signaling via heterotrimeric G proteins plays a crucial role in modulating the responses of striatal neurons that ultimately shape core behaviors mediated by the basal ganglia circuitry, such as reward valuation, habit formation and movement coordination.
Keqiang eXie, Kirill eMartemyanov
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Role of Structural Dynamics at the Receptor G Protein Interface for Signal Transduction. [PDF]
GPCRs catalyze GDP/GTP exchange in the α-subunit of heterotrimeric G proteins (Gαßγ) through displacement of the Gα C-terminal α5 helix, which directly connects the interface of the active receptor (R*) to the nucleotide binding pocket of G.
Alexander S Rose +5 more
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The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1. [PDF]
Heterotrimeric G protein α subunits are activated upon exchange of GDP for GTP at the nucleotide binding site of Gα, catalyzed by guanine nucleotide exchange factors (GEFs). In addition to transmembrane G protein-coupled receptors (GPCRs), which act on G
Celestine J Thomas +7 more
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RGG1, Involved in the Cytokinin Regulatory Pathway, Controls Grain Size in Rice
Heterotrimeric GTP binding proteins (G proteins) and cytokinin play important roles in regulating plant growth and development. However, little is known about the mechanism by which they coordinate the regulation of grain size in rice.
Yajun Tao +12 more
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The chloroplast import receptor Toc34 functions as preprotein-regulated GTPase [PDF]
Toc34 is a protein of the chloroplast outer envelope membrane that acts as receptor for preproteins containing a transit sequence. The recognition of preproteins by Toc34 is regulated by GTP binding and phosphorylation.
Soll, J. +5 more
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Current Topics in Heterotrimeric GTP-binding Proteins. Heterotrimeric G proteins and ion channels.
Direct G protein regulation of ion channels is one of the major mechanisms of the functional regulation of excitable cells by hormones and neurotransmitters. Recent extensive studies indicate that a number of channels are directly regulated by G proteins.
YAMADA, Mitsuhiko, KURACHI, Yoshihisa
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Plant growth and grain filling are the key agronomical traits for grain weight and yield of rice. The continuous improvement in rice yield is required for a future sustainable global economy and food security.
Akshaya K. Biswal +10 more
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Comparative structural dynamic analysis of GTPases.
GTPases regulate a multitude of essential cellular processes ranging from movement and division to differentiation and neuronal activity. These ubiquitous enzymes operate by hydrolyzing GTP to GDP with associated conformational changes that modulate ...
Hongyang Li, Xin-Qiu Yao, Barry J Grant
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