Results 21 to 30 of about 11,723 (175)

Control of striatal signaling by G protein regulators

Frontiers in Neuroanatomy, 2011
Signaling via heterotrimeric G proteins plays a crucial role in modulating the responses of striatal neurons that ultimately shape core behaviors mediated by the basal ganglia circuitry, such as reward valuation, habit formation and movement coordination.
Keqiang eXie, Kirill eMartemyanov
doaj   +1 more source

The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1. [PDF]

PLoS ONE, 2011
Heterotrimeric G protein α subunits are activated upon exchange of GDP for GTP at the nucleotide binding site of Gα, catalyzed by guanine nucleotide exchange factors (GEFs). In addition to transmembrane G protein-coupled receptors (GPCRs), which act on G
Celestine J Thomas, Klára Briknarová, Jonathan K Hilmer, Navid Movahed, Brian Bothner, John P Sumida, Gregory G Tall, Stephen R Sprang   +7 more
doaj   +1 more source

The association of heterotrimeric GTP-binding protein (Go) with microtubules

Journal of Biomedical Science, 2001
The heterotrimeric GTP-binding regulatory proteins (G proteins) play an important role in the regulation of membrane signal transduction. Recently, we identified the association of Go protein with mitotic spindles. Here we have investigated the relationship between Go protein and microtubules. We used temperature-dependent reversible assembly and taxol
H C, Wu, C Y, Chiu, P H, Huang, C T, Lin
openaire   +2 more sources

RGG1, Involved in the Cytokinin Regulatory Pathway, Controls Grain Size in Rice

Rice, 2020
Heterotrimeric GTP binding proteins (G proteins) and cytokinin play important roles in regulating plant growth and development. However, little is known about the mechanism by which they coordinate the regulation of grain size in rice.
Yajun Tao, Jun Miao, Jun Wang, Wenqi Li, Yang Xu, Fangquan Wang, Yanjie Jiang, Zhihui Chen, Fangjun Fan, Mengbin Xu, Yong Zhou, Guohua Liang, Jie Yang   +12 more
doaj   +1 more source

Phase specific association of heterotrimeric GTP-binding proteins with the actin-based cytoskeleton during thrombin receptor-mediated platelet activation

, 1996
Subcellular distribution of heterotrimeric GTP-binding proteins during thrombin receptor-mediated platelet activation was examined, revealing two phases of translocation to the cytoskeleton.
Sobue, Kenji, Ozawa, Kentaro, Takahashi, Masahiko   +2 more
core   +2 more sources

Novel Mutant Alleles Reveal a Role of the Extra-Large G Protein in Rice Grain Filling, Panicle Architecture, Plant Growth, and Disease Resistance

Frontiers in Plant Science, 2022
Plant growth and grain filling are the key agronomical traits for grain weight and yield of rice. The continuous improvement in rice yield is required for a future sustainable global economy and food security.
Akshaya K. Biswal, Akshaya K. Biswal, Ting-Ying Wu, Daisuke Urano, Daisuke Urano, Rémi Pelissier, Jean-Benoit Morel, Alan M. Jones, Alan M. Jones, Ajaya K. Biswal, Ajaya K. Biswal   +10 more
doaj   +1 more source

The G-protein α subunit GhGPA positively regulates Gossypium hirsutum resistance to Verticillium dahliae via induction of SA and JA signaling pathways and ROS accumulation

Crop Journal, 2021
Verticillium wilt, a devastating disease in cotton caused by Verticillium dahliae, reduces cotton quality and yield. Heterotrimeric GTP-binding proteins, consisting of Gα, Gβ, and Gγ subunits, transducers of receptor signaling, function in a wide range ...
Bin Chen, Yan Zhang, Jun Yang, Man Zhang, Qingming Ma, Xingfen Wang, Zhiying Ma   +6 more
doaj   +1 more source

Comparative structural dynamic analysis of GTPases.

PLoS Computational Biology, 2018
GTPases regulate a multitude of essential cellular processes ranging from movement and division to differentiation and neuronal activity. These ubiquitous enzymes operate by hydrolyzing GTP to GDP with associated conformational changes that modulate ...
Hongyang Li, Xin-Qiu Yao, Barry J Grant
doaj   +1 more source

Current Topics in Heterotrimeric GTP-binding Proteins. Heterotrimeric G proteins and ion channels.

Folia Pharmacologica Japonica, 1994
Direct G protein regulation of ion channels is one of the major mechanisms of the functional regulation of excitable cells by hormones and neurotransmitters. Recent extensive studies indicate that a number of channels are directly regulated by G proteins.
Mitsuhiko YAMADA, Yoshihisa KURACHI
openaire   +3 more sources

Dopamine D2L receptor-interacting proteins regulate dopaminergic signaling

Journal of Pharmacological Sciences, 2017
Dopamine receptor family proteins include seven transmembrane and trimeric GTP-binding protein-coupled receptors (GPCRs). Among them, the dopamine D2 receptor (D2R) is most extensively studied.
Norifumi Shioda
doaj   +1 more source