Results 11 to 20 of about 11,723 (175)
Activation of phospholipase C beta 4 by heterotrimeric GTP-binding proteins.
Journal of Biological Chemistry, 1994 Transient transfection assays were used to determine how the activity of phospholipase C beta 4, which is preferentially expressed in retina, was regulated. An expression vector carrying the full-length cDNA corresponding to phospholipase C beta 4 was constructed and co-transfected into COS-7 cells together with cDNA encoding the alpha subunits of the ...
H, Jiang, D, Wu, M I, Simon
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BiomedicinesSodium fluoride (NaF) is a fluoride application recommended by the World Health Organization for its efficacy and safety in preventing dental caries. Gingival fibroblasts that constitute the majority of connective tissue cells play a major role in wound ...
Nobue Kato +6 more
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Structure and Function of Heterotrimeric GTP-binding Proteins Involved in Signal Transduction.
membrane, 1994 Kanaho, Yasunori, Katada, Toshiaki
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Cells, 2021 Heterotrimeric G proteins are immediate transducers of G protein-coupled receptors—the biggest receptor family in metazoans—and play innumerate functions in health and disease. A set of de novo point mutations in GNAO1 and GNAI1, the genes encoding the α-
Gonzalo P. Solis +17 more
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G protein activation without a GEF in the plant kingdom. [PDF]
PLoS Genetics, 2012 Animal heterotrimeric G proteins are activated by guanine nucleotide exchange factors (GEF), typically seven transmembrane receptors that trigger GDP release and subsequent GTP binding.
Daisuke Urano +6 more
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A Putative Non-Canonical Ras-Like GTPase from P. falciparum: Chemical Properties and Characterization of the Protein. [PDF]
PLoS ONE, 2015 During its development the malaria parasite P. falciparum has to adapt to various different environmental contexts. Key cellular mechanisms involving G-protein coupled signal transduction chains are assumed to act at these interfaces.
Annette Kaiser +4 more
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GTP Binding Assays in Arabidopsis thaliana
Bio-Protocol, 2013 Signaling through G proteins constitutes an ancient mechanism that functions in the transduction of extracellular signals into intracellular responses. Activation of a proper receptor by a stimuli leads to an exchange of GDP for GTP, the activation of G ...
Ana Fox, Maria Mazzella
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A Sugarcane G-Protein-Coupled Receptor, ShGPCR1, Confers Tolerance to Multiple Abiotic Stresses
Frontiers in Plant Science, 2021 Sugarcane (Saccharum spp.) is a prominent source of sugar and serves as bioenergy/biomass feedstock globally. Multiple biotic and abiotic stresses, including drought, salinity, and cold, adversely affect sugarcane yield.
Manikandan Ramasamy +12 more
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Role of heterotrimeric Gα proteins in maize development and enhancement of agronomic traits. [PDF]
PLoS Genetics, 2018 Plant shoot systems derive from the shoot apical meristems (SAMs), pools of stems cells that are regulated by a feedback between the WUSCHEL (WUS) homeobox protein and CLAVATA (CLV) peptides and receptors.
Qingyu Wu +3 more
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Role of Structural Dynamics at the Receptor G Protein Interface for Signal Transduction. [PDF]
PLoS ONE, 2015 GPCRs catalyze GDP/GTP exchange in the α-subunit of heterotrimeric G proteins (Gαßγ) through displacement of the Gα C-terminal α5 helix, which directly connects the interface of the active receptor (R*) to the nucleotide binding pocket of G.
Alexander S Rose +5 more
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