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Nature Reviews Molecular Cell Biology, 2005
The focus of developmental biologists has expanded from the analysis of gene expression to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate signalling from a superfamily of heptahelical receptors (G-protein-coupled receptors) to a smaller number of effector units that include adenylyl cyclases, phospholipase C and
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The focus of developmental biologists has expanded from the analysis of gene expression to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate signalling from a superfamily of heptahelical receptors (G-protein-coupled receptors) to a smaller number of effector units that include adenylyl cyclases, phospholipase C and
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G-protein-independent signaling by G-protein-coupled receptors
Trends in Neurosciences, 2000Two classes of receptors transduce neurotransmitter signals: ionotropic receptors and heptahelical metabotropic receptors. Whereas the ionotropic receptors are structurally associated with a membrane channel, a mediating mechanism is necessary to functionally link metabotropic receptors with their respective effectors.
Heuss, C, Gerber, U
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New England Journal of Medicine, 1995
The award of the 1994 Nobel Prize in Physiology or Medicine to Alfred G. Gilman and Martin Rodbell for the discovery of G (guanine nucleotide–binding) proteins and their role in cellular signal tra...
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The award of the 1994 Nobel Prize in Physiology or Medicine to Alfred G. Gilman and Martin Rodbell for the discovery of G (guanine nucleotide–binding) proteins and their role in cellular signal tra...
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G-Proteins and Endothelial Responses
Journal of Vascular Research, 1990G-proteins are transducing proteins that couple a large number of membrane-bound receptors to a variety of intracellular effector systems. Pertussis toxin ADP-ribosylates certain G-proteins causing inhibition of their function. In porcine coronary arteries, pertussis toxin inhibited the endothelium-dependent relaxations evoked by alpha-2-adrenergic or ...
Flavahan, NA, Vanhoutte, PM
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G-Protein Subunit Dissociation Is not an Integral Part of G-Protein Action
ChemBioChem, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Alexander, Levitzki, Shoshana, Klein
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Conditional Mutagenesis of G-Protein Coupled Receptors and G-Proteins
2007The G-protein-coupled receptor signaling system, consisting of a huge variety of receptors as well as of many G-proteins and effectors, operates in every cell and is involved in many physiological and pathological processes. The versatility of this system and the involvement of specific components makes G-protein-coupled receptors and their signaling ...
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Structure of G Protein–Coupled Receptors and G Proteins
Science's STKE, 2005This Teaching Resource provides lecture notes and slides for a class covering the structure and function of G protein–coupled receptors and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with a discussion of the crystal structure of rhodopsin and G protein subunits and then proceeds to describe the ...
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G Proteins In Signal Transduction
Annual Review of Pharmacology and Toxicology, 1990The last five years have seen major advances in our understanding of the central and generalized role of G-proteins as transducers of receptor signals into effector responses as outlined in Scheme 1. Signal-transducing G pro teins, in contrast to other GTP-binding proteins, are heterotrimers formed of one GTP-binding (and hydrolyzing) a subunit, one ...
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G-proteins | G Protein Signaling Regulators
2021John H. Exton, Sarah C. Stainbrook
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