Results 191 to 200 of about 774,543 (406)

Deep Learning Dynamic Allostery of G‑Protein-Coupled Receptors

JACS Au, 2023
Hung N. Do, Jinan Wang, Yinglong Miao
doaj   +1 more source

The structure and function of G-protein-coupled receptors

Nature, 2009
D. Rosenbaum, S. Rasmussen, B. Kobilka
semanticscholar   +1 more source

Thyrotropin-releasing hormone activates Ca2+ efflux. Evidence suggesting that a plasma membrane Ca2+ pump is an effector for a G-protein-coupled Ca(2+)-mobilizing receptor.

, 1994
Eric J. Nelson, Patricia M. Hinkle
openalex   +1 more source

Sustained Activation of a G Protein-coupled Receptor via “Anchored” Agonist Binding [PDF]

, 1996
Stuart A. Green, Andrew P. Spasoff, Robert A. Coleman, Malcolm Johnson, Stephen B. Liggett   +4 more
openalex   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Application of FRET- and BRET-based live-cell biosensors in deorphanization and ligand discovery studies on orphan G protein-coupled receptors

SLAS Discovery
Bioluminescence- and fluorescence-based resonance energy transfer assays have gained considerable attention in pharmacological research as high-throughput scalable tools applicable to drug discovery. To this end, G protein-coupled receptors represent the
Joanna J. Sajkowska, Choi Har Tsang, Paweł Kozielewicz   +2 more
doaj  

Discovery of new G protein-coupled receptors for lipid mediators

Journal of Lipid Research, 2004
Successful sequencing of the human genome has opened a new era in the life sciences and has greatly accelerated biomedical research. Among various research endeavors benefiting from established genomic information, one of the most fruitful areas is the ...
Dong-Soon Im
doaj  

Inhibition of G-protein-coupled Receptor Function by Disruption of Transmembrane Domain Interactions [PDF]

, 1999
Nadya I. Tarasova, William G. Rice, Christopher J. Michejda   +2 more
openalex   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.

, 1994
Kenji Ishii, J. Chen, Maki Ishii, Walter J. Koch, Neil J. Freedman, R J Lefkowitz, Shaun R. Coughlin   +6 more
openalex   +1 more source