Results 91 to 100 of about 12,561,590 (387)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Non-G Base Tetrads

Molecules, 2022
Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures have attracted enormous attention in the last few years, being the most ...
Núria Escaja, Bartomeu Mir, Miguel Garavís, Carlos González   +3 more
doaj   +1 more source

Normalized Affymetrix expression data are biased by G-quadruplex formation [PDF]

, 2011
Probes with runs of four or more guanines (G-stacks) in their sequences can exhibit a level of hybridization that is unrelated to the expression levels of the mRNA that they are intended to measure.
Altman, Andrew P. Harrison, Barrett, Bolstad, Burge, Cambon, Do, Dudoit, Eisen, Farhat N. Memon, Geller, Gellert, Giorgi, Graham J. G. Upton, Hammond, Harris, Hochreiter, Hubbell, Hugh P. Shanahan, Irizarry, Irizarry, Iwamoto, Kittleson, Langdon, Li, Memon, Memon, Naef, Patterson, Ringnér, Ryan, Sen, Stalteri, Upton, Upton, Walton, Wu   +36 more
core   +3 more sources

Stability of telomeric G-quadruplexes [PDF]

Nucleic Acids Research, 2010
In most eukaryotes, telomeric DNA consists of repeats of a short motif that includes consecutive guanines and may hence fold into G-quadruplexes. Budding yeasts have telomeres composed of longer repeats and show variation in the degree of repeat homogeneity. Although telomeric sequences from several organisms have been shown to fold into G-quadruplexes
Tran, Phong Lan Thao, Mergny, Jean-Louis, Alberti, Patrizia   +2 more
openaire   +3 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Specific Binding of Anionic Porphyrin and Phthalocyanine to the G-Quadruplex with a Variety of <em>i</em><em>n Vitro</em> and<em> </em><em>i</em><em>n Vivo</em> Applications

Molecules, 2012
The G-quadruplex, a four-stranded DNA structure with stacked guanine tetrads (G-quartets), has recently been attracting attention because of its critical roles<em> in vitro</em> and<em> in vivo</em>.
Naoki Sugimoto, Daisuke Miyoshi, Takashi Murashima, Hidenobu Yaku   +3 more
doaj   +1 more source

Nanostructured luminescently labeled nucleic acids [PDF]

, 2017
Important and emerging trends at the interface of luminescence, nucleic acids and nanotechnology are: (i) the conventional luminescence labeling of nucleic acid nanostructures (e.g. DNA tetrahedron); (ii) the labeling of bulk nucleic acids (e.g. single‐
Adleman, Ai, Beater, Bi, Branton, Cao, Casini, Chen, Corstjens, Deng, Ding, Ding, Ding, Divsar, Du, Duan, Dunn, ENCODE, Fortina, Fortina, Gerling, Gommers-Ampt, Goodman, Han, He, He, He, He, He, Hembury, Heuer-Jungemann, Horikoshi, Hu, Huang, Jia, Ke, Kim, Knoblauch, Kricka, Kricka, Kwok, Lee, Li, Li, Lin, Liu, Liu, Liu, Lu, Ma, Maden, Mouse ENCODE Consortium, Nangreave, Nirenberg, Obliosca, Orbach, Ozhalici-Unal, Park, Park, Parker, Petty, Pinehiro, Randeria, Ren, Richards, Rijke, Ritchie, Rotaru, Rothemund, Seeman, Seferos, Severcan, Sharma, Shchepinov, Shen, Simonetti, Stahl, Stolper, Taton, Vanyushin, Vasudevan, Vummidi, Wang, Wang, Wang, Wang, Wang, Wang, Wu, Wu, Yan, Yang, Yang, Yang, Ye, Yeh, Yu, Yuan, Yurke, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zhou   +105 more
core   +1 more source

DNA G-quadruplex structures mould the DNA methylome

Nature Structural & Molecular Biology, 2018
Control of DNA methylation level is critical for gene regulation, and the factors that govern hypomethylation at CpG islands (CGIs) are still being uncovered.
Shiqing Mao, A. Ghanbarian, Jochen Spiegel, Sergio Martínez Cuesta, D. Beraldi, M. Di Antonio, Giovanni Marsico, Robert Hänsel-Hertsch, D. Tannahill, S. Balasubramanian   +9 more
semanticscholar   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Parallel G-quadruplex recognition by neomycin

Frontiers in Chemistry, 2023
G-quadruplex-forming nucleic acids have evolved to have applications in biology, drug design, sensing, and nanotechnology, to name a few. Together with the structural understanding, several attempts have been made to discover and design new classes of ...
Nihar Ranjan, Dev P. Arya
doaj   +1 more source