Results 111 to 120 of about 32,657 (295)

Principal factors that determine the extension of detection range in molecular beacon aptamer/conjugated polyelectrolyte bioassays. [PDF]

, 2015
A strategy to extend the detection range of weakly-binding targets is reported that takes advantage of fluorescence resonance energy transfer (FRET)-based bioassays based on molecular beacon aptamers (MBAs) and cationic conjugated polyelectrolytes (CPEs).
Bazan, Guillermo C, Hwang, Sungu, Jeong, Ji-Eun, Kim, Boram, Woo, Han Young, Woo, Shinjae   +5 more
core   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Antiparallel RNA G-quadruplex Formed by Human Telomere RNA Containing 8-Bromoguanosine

Scientific Reports, 2017
In this study, by combining nuclear magnetic resonance (NMR), circular dichroism (CD), liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS), and gel electrophoresis, we report an unusual topological structure of the RNA G ...
Chao-Da Xiao, Takumi Ishizuka, Yan Xu
doaj   +1 more source

Targeting G-Quadruplex DNA with Small Molecules

CHIMIA, 2009
Despite a recent explosion of interest in G-quadruplex DNA, most fundamental questions regarding the possible presence and function of these intriguing structures in vivo remain unanswered.
Nathan W. Luedtke
doaj   +1 more source

Design of surface-active artificial enzyme particles to stabilize Pickering emulsions for high-performance biphasic biocatalysis [PDF]

, 2015
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Surface-active artificial enzymes (SAEs) are designed and constructed by a general and novel strategy.
Baciocchi, Binks, Bonomi, Chen, Chen, Crossley, Dewey, Diez-Castellnou, Gao, Jiang, Kapil, Kosif, Köhler, Li, Li, Lin, Liu, Liu, Mondloch, Nanda, Natalio, Neverov, Pengo, Pera-Titus, Silverman, Smith, Song, Sun, Tonga, Vernekar, Wang, Wang, Wang, Wiese, Wu, Yang, Zapata, Zaramella, Zhang, Zhou   +39 more
core   +1 more source

Pentagonal 2D Altermagnets: Material Screening and Altermagnetic Tunneling Junction Device Application

Advanced Functional Materials, EarlyView.
From a database of 170 pentagonal 2D materials, 4 candidates exhibiting altermagnetic ordering are screened. Furthermore, the spin‐splitting and unconventional boundary states in the pentagonal 2D altermagnetic monolayer MnS2 are investigated. A MnS2‐based altermagnetic tunneling junction is designed and, through ab initio quantum transport simulations,
Jianhua Wang, Xingyue Yang, Zongmeng Yang, Jing Lu, Pin Ho, Wenhong Wang, Yee Sin Ang, Zhenxiang Cheng, Shibo Fang   +8 more
wiley   +1 more source

The oxidative damage to the human telomere: effects of 5-hydroxymethyl-2'-deoxyuridine on telomeric G-quadruplex structures [PDF]

, 2015
As part of the genome, human telomeric regions can be damaged by the chemically reactive molecules responsible for oxidative DNA damage. Considering that G-quadruplex structures have been proven to occur in human telomere regions, several studies have ...
ESPOSITO, VERONICA, GALEONE, ALDO, GIANCOLA, CONCETTA, MAYOL, LUCIANO, PETRACCONE, LUIGI, VIRGILIO, ANTONELLA   +5 more
core   +1 more source

Composites of Shellac and Silver Nanowires as Flexible, Biobased, and Corrosion‐Resistant Transparent Conductive Electrodes

Advanced Functional Materials, EarlyView.
Shellac, a centuries‐old natural resin, is reimagined as a green material for flexible electronics. When combined with silver nanowires, shellac films deliver transparency, conductivity, and stability against humidity. These results position shellac as a sustainable alternative to synthetic polymers for transparent conductors in next‐generation ...
Rahaf Nafez Hussein, Tiago Carneiro Gomes, Eliza Ng, Simon Rondeau‐Gagné, Tricia Breen Carmichael   +4 more
wiley   +1 more source

Characterization of G-Quadruplex Motifs in espB, espK, and cyp51 Genes of Mycobacterium tuberculosis as Potential Drug Targets

Molecular Therapy: Nucleic Acids, 2019
G-quadruplex structure forming motifs are among the most studied evolutionarily conserved drug targets that are present throughout the genome of different organisms and susceptible to influencing various biological processes.
Subodh Kumar Mishra, Uma Shankar, Neha Jain, Kriti Sikri, Jaya Sivaswami Tyagi, Tarun Kumar Sharma, Jean-Louis Mergny, Amit Kumar   +7 more
doaj   +1 more source

Strand directionality affects cation binding and movement within tetramolecular G-quadruplexes [PDF]

, 2012
Nuclear magnetic resonance study of G-quadruplex structures formed by d(TG3T) and its modified analogs containing a 50-50 or 30-30 inversion of polarity sites, namely d(30TG50-50G2T30), d(30T50- 50G3T30) and d(50TG30-30G2T5’) demonstrates formation ...
ESPOSITO, VERONICA, GALEONE, ALDO, Janez Plavec, Primoz Sket, VIRGILIO, ANTONELLA   +4 more
core   +2 more sources