Results 281 to 290 of about 32,657 (295)
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Nonaqueous G-Quadruplex Ionogels
LangmuirSupramolecular ionogels, as an emerging class of materials, utilize the intriguing properties of ionic liquids (ILs) and offer a promising method for constructing functional materials in anhydrous solvents. G-Quadruplex, assembled from guanine-rich nucleic acid building blocks, is an important structure closely associated with life and leads to the ...
Zeyi Wang +4 more
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G-quadruplexes as therapeutic targets
Biopolymers, 2000The ends of chromosomes (telomeres) consist of tandem repeats of guanine-rich sequences. In eukaryotics, telomeric DNA is single stranded for the final few hundred bases. These single-stranded sequences can fold into a variety of four-stranded structures (quadruplexes) held together by quartets of hydrogen-bonded guanine bases.
S, Neidle, M A, Read
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Current Protocols in Nucleic Acid Chemistry, 2009
AbstractAbsorbance versus temperature curves can provide information on the thermal stability of DNA or RNA quadruplexes. Quadruplex denaturation or renaturation can be followed by recording absorbance at 295 nm rather than 260 nm, the wavelength used to monitor duplex denaturation. This unit describes the use of absorbance versus temperature curves to
Jean-Louis, Mergny, Laurent, Lacroix
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AbstractAbsorbance versus temperature curves can provide information on the thermal stability of DNA or RNA quadruplexes. Quadruplex denaturation or renaturation can be followed by recording absorbance at 295 nm rather than 260 nm, the wavelength used to monitor duplex denaturation. This unit describes the use of absorbance versus temperature curves to
Jean-Louis, Mergny, Laurent, Lacroix
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Thermodynamics of G-quadruplexes
2012In 1910 Ivar Bang reported that concentrated solutions of guanylic acid formed a gel. It took half a century before Gellert et al. in 1962 discovered the structural motif, a guanine-quartet, to be the basis for guanylic acid gelation. This chapter starts with a historical overview and gives credit to Ivar Bang and several other pioneers in the field ...
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WIREs RNA, 2012
AbstractG‐quadruplexes are noncanonical structures formed by G‐rich DNA and RNA sequences that fold into a four‐stranded conformation. Experimental studies and computational predictions show that RNA G‐quadruplexes are present in transcripts associated with telomeres, in noncoding sequences of primary transcripts and within mature transcripts.
Stefania, Millevoi +2 more
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AbstractG‐quadruplexes are noncanonical structures formed by G‐rich DNA and RNA sequences that fold into a four‐stranded conformation. Experimental studies and computational predictions show that RNA G‐quadruplexes are present in transcripts associated with telomeres, in noncoding sequences of primary transcripts and within mature transcripts.
Stefania, Millevoi +2 more
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2011
Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex.
Nancy H, Campbell, Stephen, Neidle
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Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex.
Nancy H, Campbell, Stephen, Neidle
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Transposable elements and G-quadruplexes
Chromosome Research, 2015A significant part of eukaryotic genomes is formed by transposable elements (TEs) containing not only genes but also regulatory sequences. Some of the regulatory sequences located within TEs can form secondary structures like hairpins or three-stranded (triplex DNA) and four-stranded (quadruplex DNA) conformations.
Eduard, Kejnovsky +2 more
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Unlocking G-quadruplex: Effect of unlocked nucleic acid on G-quadruplex stability
Biochimie, 2011G-quadruplexes are common structural motifs in aptamers. UNA or unlocked nucleic acid is the latest nucleic acid modification. We have attempted to evaluate the impact of UNA modification on the structure and stability of G-quadruplex oligonucleotides for application in aptamer design.
Tani, Agarwal +2 more
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Bulges in G-Quadruplexes: Broadening the Definition of G-Quadruplex-Forming Sequences
Journal of the American Chemical Society, 2013We report on the first solution structure of an intramolecular G-quadruplex containing a single bulge and present evidence for extensive occurrence of bulges in different G-quadruplex contexts. The NMR solution structure of the d(TTGTGGTGGGTGGGTGGGT) sequence reveals a propeller-type parallel-stranded G-quadruplex containing three G-tetrad layers ...
Vineeth Thachappilly, Mukundan +1 more
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Fluorescent Probes for G‐Quadruplex Structures
ChemBioChem, 2013AbstractMounting evidence supports the presence of biologically relevant G‐quadruplexes in single‐cell organisms, but the existence of endogenous G‐quadruplex structures in mammalian cells remains highly controversial. This is due, in part, to the common misconception that DNA and RNA molecules are passive information carriers with relatively little ...
Vummidi, B R, Alzeer, J, Luedtke, N W
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