Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines
BMC Research Notes, 2012 Background Guanosine rich sequences capable of forming G-quadruplex (G4) motifs are enriched near the gene transcription start site (TSS) in the human genome.
Halder Rashi +4 more
doaj +1 more source
NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds [PDF]
, 2019 G-quadruplexes are noncanonical, four-stranded nucleic acid secondary structures formed in sequences containing consecutive runs of guanines. These G-quadruplex structures have been found to form in nucleic acid regions of biological significance, including human telomeres, gene promoters, and untranslated regions of mRNA.
Clement, Lin +2 more
openaire +2 more sources
Three-dimensional modeling of single stranded DNA hairpins for aptamer-based biosensors. [PDF]
, 2017 Aptamers consist of short oligonucleotides that bind specific targets. They provide advantages over antibodies, including robustness, low cost, and reusability.
Jeddi, Iman, Saiz, Leonor
core +2 more sources
Discovery of G-quadruplex-forming sequences in SARS-CoV-2
Briefings Bioinform., 2020 The outbreak caused by the novel coronavirus SARS-CoV-2 has been declared a global health emergency. G-quadruplex structures in genomes have long been considered essential for regulating a number of biological processes in a plethora of organisms.
Danyang Ji +5 more
semanticscholar +1 more source
Spectroscopic Characterization of Mitochondrial G-Quadruplexes [PDF]
International Journal of Molecular Sciences, 2022 Guanine quadruplexes (G4s) are highly polymorphic four-stranded structures formed within guanine-rich DNA and RNA sequences that play a crucial role in biological processes. The recent discovery of the first G4 structures within mitochondrial DNA has led to a small revolution in the field.
Sara Illodo +5 more
openaire +3 more sources
Novel splicing in IGFN1 intron 15 and role of stable G-quadruplex in the regulation of splicing in renal cell carcinoma. [PDF]
PLoS ONE, 2018 The IGFN1 (Immunoglobulin-Like And Fibronectin Type III Domain Containing 1) gene has a role in skeletal muscle function and is also involved in metastatic breast cancer, and the isoforms with three N-terminal globular domains are sufficient for its ...
Shiv Prakash Verma, Parimal Das
doaj +1 more source
Identification of G-quadruplex DNA/RNA binders: Structure-based virtual screening and biophysical characterization [PDF]
, 2017 Background Recent findings demonstrated that, in mammalian cells, telomere DNA (Tel) is transcribed into telomeric repeat-containing RNA (TERRA), which is involved in fundamental biological processes, thus representing a promising anticancer target. For
Alcaro, Stefano +11 more
core +1 more source
G-Quadruplex Aptamer-Ligand Characterization
Molecules, 2022 In this work we explore the structure of a G-rich DNA aptamer termed AT11-L2 (TGGTGGTGGTTGTTGTTGGTGGTGGTGGT; derivative of AT11) by evaluating the formation and stability of G-quadruplex (G4) conformation under different experimental conditions such as KCl concentration, temperature, and upon binding with a variety of G4 ligands (360A, BRACO-19, PDS ...
David Moreira +9 more
openaire +4 more sources
Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription [PDF]
, 2015 Folding of the LTR promoter into dynamic G-quadruplex conformations has been shown to suppress its transcriptional activity in HIV-1. Here we sought to identify the proteins that control the folding of this region of proviral genome by inducing ...
Butovskaya, Elena +8 more
core +2 more sources
Responsive DNA G-quadruplex micelles [PDF]
Chemical Communications, 2018 A novel design of DNA-G-quadruplex micelles is presented, which can be disassembled by addition of a complementary strand, resulting in the release of an embedded cargo.
Liliana Cozzoli +4 more
openaire +3 more sources