Results 61 to 70 of about 14,208,503 (293)
A guide to computational methods for G-quadruplex prediction
Nucleic Acids Research, 2019 Guanine-rich nucleic acids can fold into the non-B DNA or RNA structures called G-quadruplexes (G4). Recent methodological developments have allowed the characterization of specific G-quadruplex structures in vitro as well as in vivo, and at a much ...
E. Puig Lombardi, A. Londoño-Vallejo
semanticscholar +1 more source
G-quadruplex based biosensor: A potential tool for SARS-CoV-2 detection
Biosensors & bioelectronics, 2020 G-quadruplex is a non-canonical nucleic acid structure formed by the folding of guanine rich DNA or RNA. The conformation and function of G-quadruplex are determined by a number of factors, including the number and polarity of nucleotide strands, the ...
Hui Xi, Mario Juhas, Yang Zhang
semanticscholar +1 more source
Tuning Thermoresponsive Supramolecular G-Quadruplexes [PDF]
Langmuir, 2015 Thermoresponsive systems are attractive due to their suitability for fundamental studies as well as their practical uses in a wide variety of applications. While much progress has been achieved using polymers, alternative strategies such as the use of well-defined nonpolymeric supramolecules are still underdeveloped.
José E, Betancourt, José M, Rivera
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G-Quadruplexes in the Archaea Domain [PDF]
Biomolecules, 2020 The importance of unusual DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, G-quadruplexes (G4s) have gained in popularity during the last decade, and their presence and functional relevance at the DNA and RNA level has been demonstrated in a number of viral, bacterial ...
Václav Brázda +13 more
openaire +6 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Formation of G-quadruplex and Its Utilizing for an Automated Spectrometric Detection of Cisplatin
International Journal of Electrochemical Science, 2015 Here, we studied the formation of G-quadruplex using spectrophotometric methods (peroxidase activity of G-quadruplex) and verifications of obtained results by voltammetry (cytosine-adenine (CA) or guanine (G) peaks height).
Branislav Ruttkay-Nedecky +9 more
doaj +1 more source
G4mismatch: Deep neural networks to predict G-quadruplex propensity based on G4-seq data.
PLoS Computational Biology, 2023 G-quadruplexes are non-B-DNA structures that form in the genome facilitated by Hoogsteen bonds between guanines in single or multiple strands of DNA.
Mira Barshai +3 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Hemin/G-quadruplex DNAzyme for Designing of Electrochemical Sensors
International Journal of Electrochemical Science, 2015 Guanine-rich nucleic acid sequence can fold into guanine quadruplex (G-quadruplex) that is found to complex tightly with hemin to form the hemin/G-quadruplex.
Guo-Cheng Han +2 more
doaj +1 more source
Stability of telomeric G-quadruplexes [PDF]
Nucleic Acids Research, 2010 In most eukaryotes, telomeric DNA consists of repeats of a short motif that includes consecutive guanines and may hence fold into G-quadruplexes. Budding yeasts have telomeres composed of longer repeats and show variation in the degree of repeat homogeneity. Although telomeric sequences from several organisms have been shown to fold into G-quadruplexes
Tran, Phong Lan Thao +2 more
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