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Yeast G1 cyclins are unstable in G1 phase
Nature, 1998In most eukaryotes, commitment to cell division occurs in late G1 phase at an event called Start in the yeast Saccharomyces cerevisiae, and called the restriction point in mammalian cells. Start is triggered by the cyclin-dependent kinase Cdc28 and three rate-limiting activators, the G1 cyclins Cln1, Cln2 and Cln3.
B L, Schneider +6 more
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The G1 distribution of “G1-less” V79 Chinese hamster cells
Experimental Cell Research, 1983The V79-8 line of Chinese hamster cells has been reported to lack a measurable G1 phase. However, using a combination of time-lapse cinemicroscopy and [3H]thymidine autoradiography, we have found these cells to have a median G1 duration ranging from 1.4 to 2.6 h in different experiments, accounting for more than 15% of the median cycle time.
R F, Brooks +3 more
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1998
The cell cycle describes the ordered process by which a cell executes the four essential tasks required to produce a duplicate of itself: growth (increase in mass), chromosomal duplication, chromosomal segregation, and cellular division (Mitchison 1971).
R J, Sheaff, J M, Roberts
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The cell cycle describes the ordered process by which a cell executes the four essential tasks required to produce a duplicate of itself: growth (increase in mass), chromosomal duplication, chromosomal segregation, and cellular division (Mitchison 1971).
R J, Sheaff, J M, Roberts
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Current Opinion in Cell Biology, 1994
D- and E-type cyclins regulate the progression of mammalian cells through the G1 phase of the cell cycle. The mechanisms responsible for the accumulation and activation of kinases dependent on cyclins D and E in both normal and cancerous cells have recently been uncovered.
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D- and E-type cyclins regulate the progression of mammalian cells through the G1 phase of the cell cycle. The mechanisms responsible for the accumulation and activation of kinases dependent on cyclins D and E in both normal and cancerous cells have recently been uncovered.
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Aberrations of the G1- and G1/S-regulating genes in human cancer
1997Deregulated cell proliferation is the hallmark of cancer, and convergent data from the fields of cell-cycle research and molecular oncology have revealed the key role played by abnormalities of the cell-cycle control genes in multistep tumorigenesis. Along with the p53-mediated DNA damage checkpoint, the G1-governing pathway of D-type cyclins, their ...
J, Bartkova, J, Lukas, J, Bartek
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Anisotropic membranes with carboxypeptidase G1
Applied Biochemistry and Biotechnology, 1983Anisotropic polysulfone membranes were prepared with carboxypeptidase G1 embedded in the polymer structure. The enzymatically active flat and hollow-fiber membranes were obtained by precipitating the polymer from solution in an organic mixture in which an aqueous solution of the enzyme had been dispersed.
A M, Pitt +5 more
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Journal of Cell Science, 1994
Cyclin-dependent kinases (Cdks) control the major cell cycle transitions in eukaryotic cells. On the basis of a variety of experiments where cyclin function either is impaired or enhanced, D-type cyclins as well as cyclins E and A have been linked to G1 and G1/S phase roles in mammalian cells.
Reed, Steven +5 more
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Cyclin-dependent kinases (Cdks) control the major cell cycle transitions in eukaryotic cells. On the basis of a variety of experiments where cyclin function either is impaired or enhanced, D-type cyclins as well as cyclins E and A have been linked to G1 and G1/S phase roles in mammalian cells.
Reed, Steven +5 more
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World Banking Abstracts, 2012
World Banking Abstracts publishes abstracts exclusively. Therefore, to see this abstract, please click the “View Full Article (HTML)” or “Get PDF” link.
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World Banking Abstracts publishes abstracts exclusively. Therefore, to see this abstract, please click the “View Full Article (HTML)” or “Get PDF” link.
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A New method to discriminate G1, S, G2, M, and G1 postmitotic cells
Experimental Cell Research, 1989A new flow cytometric method combining light scattering measurements, detection of bromodeoxyuridine (BrdU) incorporation via fluorescent antibody, and quantitation of cellular DNA content by propidium iodide (PI) allows identification of additional compartments in the cell cycle. Thus, while cell staining with BrdU-antibodies and PI reveals the G1, S,
Giaretti W +4 more
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