Results 1 to 10 of about 7,531,916 (333)
Chromatin structure dynamics during the mitosis-to-G1 phase transition. [PDF]
Nature, 2019 Features of higher-order chromatin organization—such as A/B compartments, topologically associating domains and chromatin loops—are temporarily disrupted during mitosis1,2.
Zhang H +12 more
europepmc +5 more sources
MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability [PDF]
eLife, 2014 Homologous recombination (HR)-mediated repair of DNA double-strand break (DSB)s is restricted to the post-replicative phases of the cell cycle. Initiation of HR in the G1 phase blocks non-homologous end joining (NHEJ) impairing DSB repair.
Young Eun Choi +6 more
doaj +4 more sources
Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production
Frontiers in Cellular and Infection Microbiology, 2018 Recent epidemiological data indicate that outbreaks of hand, foot, and mouth disease (HFMD), which can be categorized according to its clinical symptoms as typical or atypical, have markedly increased worldwide. A primary causative agent for typical HFMD
Zengyan Wang +13 more
doaj +2 more sources
G1-phase progression in pluripotent stem cells. [PDF]
Cell Mol Life Sci, 2021 AbstractDuring early embryonic development both the rapid increase in cell number and the expression of genes that control developmental decisions are tightly regulated. Accumulating evidence has indicated that these two seemingly independent processes are mechanistically intertwined. The picture that emerges from studies on the cell cycle of embryonic
Ter Huurne M, Stunnenberg HG.
europepmc +4 more sources
Lgr5+ intestinal stem cells reside in an unlicensed G1 phase [PDF]
Journal of Cell Biology, 2018 During late mitosis and the early G1 phase, the origins of replication are licensed by binding to double hexamers of MCM2–7. In this study, we investigated how licensing and proliferative commitment are coupled in the epithelium of the small intestine ...
Blow, John +4 more
core +3 more sources
A Cdk4/6-dependent phosphorylation gradient regulates the early to late G1 phase transition [PDF]
Scientific Reports, 2021 During early G1 phase, Rb is exclusively mono-phosphorylated by cyclin D:Cdk4/6, generating 14 different isoforms with specific binding patterns to E2Fs and other cellular protein targets.
Manuel Kaulich +6 more
doaj +2 more sources
A novel role for ATR/Rad3 in G1 phase [PDF]
Scientific Reports, 2018 Checkpoint kinases are important in cellular surveillance pathways that help cells to cope with DNA damage and protect their genomes. In cycling cells, DNA replication is one of the most sensitive processes and therefore all organisms carefully regulate ...
Cathrine A. Bøe +4 more
doaj +3 more sources
CDK inhibitors: positive and negative regulators of G1-phase progression. [PDF]
Genes & Development, 1999 Mitogen-dependent progression through the first gap phase (G1) and initiation of DNA synthesis (S phase) during the mammalian cell division cycle are cooperatively regulated by several classes of cyclin-dependent kinases (CDKs) whose activities are in ...
C. Sherr, James M. Roberts
semanticscholar +3 more sources
Cyclin D activates the Rb tumor suppressor by mono-phosphorylation [PDF]
eLife, 2014 The widely accepted model of G1 cell cycle progression proposes that cyclin D:Cdk4/6 inactivates the Rb tumor suppressor during early G1 phase by progressive multi-phosphorylation, termed hypo-phosphorylation, to release E2F transcription factors ...
Anil M Narasimha +5 more
doaj +3 more sources
Overexpression of Mouse D-Type Cyclins Accelerates G(1) Phase in Rodent Fibroblasts [PDF]
Genes & Development, 1993 Mammalian D-type cyclins are growth factor-regulated, delayed early response genes that are presumed to control progression through the G1 phase of the cell cycle by governing the activity of cyclin-dependent kinases (cdks).
Ashmun, R. A. +6 more
core +2 more sources