Results 31 to 40 of about 7,531,916 (333)

Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity. [PDF]

, 2014
A major impediment to the response of tumors to chemotherapy is that the large majority of cancer cells within a tumor are quiescent in G0/G1, where cancer cells are resistant to chemotherapy.
Bouvet, Michael, Fujiwara, Toshiyoshi, Han, Qinghong, Hoffman, Robert M, Li, Shukuan, Tan, Yuying, Yano, Shuya   +6 more
core   +3 more sources

Lovastatin induces G1-phase synchronization of HEC-1-A cells and JEC cells

Bangladesh Journal of Pharmacology, 2013
Our study investigated lovastatin-induced G1 phase synchronization of HEC-1-A cells and JEC cells and the cell cycle progression after desynchronization of these cells.
Huimin Shen, Xiaomao Li, Yuebo Yang, Xiaoyun Wang, Xu Zhang   +4 more
doaj   +1 more source

Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6

Pharmaceutics, 2022
The cyclin-dependent kinase inhibitor p27 (Kip1) is an important regulator of the G1/S checkpoint. It is degraded by the SCF-SKP2 complex in late G1 thereby allowing cells to progress to the S phase.
Dhanraj Deshmukh, Jin Xu, Xi Yang, Hermela Shimelis, Shengyun Fang, Yun Qiu   +5 more
doaj   +1 more source

A novel single virus infection system reveals that influenza virus preferentially infects cells in g1 phase. [PDF]

PLoS ONE, 2013
BackgroundInfluenza virus attaches to sialic acid residues on the surface of host cells via the hemagglutinin (HA), a glycoprotein expressed on the viral envelope, and enters into the cytoplasm by receptor-mediated endocytosis.
Ryuta Ueda, Tadao Sugiura, Shinichiro Kume, Akihiko Ichikawa, Steven Larsen, Hideaki Miyoshi, Hiroaki Hiramatsu, Yasuko Nagatsuka, Fumihito Arai, Yasuo Suzuki, Yoshio Hirabayashi, Toshio Fukuda, Ayae Honda   +12 more
doaj   +1 more source

Coherence properties of the microcavity polariton condensate [PDF]

, 2008
A theoretical model is presented which explains the dominant decoherence process in a microcavity polariton condensate. The mechanism which is invoked is the effect of self-phase modulation, whereby interactions transform polariton number fluctuations ...
Callen H. B., D. M. Whittaker, P. R. Eastham, Scully M. O.   +3 more
core   +2 more sources

RBX1 prompts degradation of EXO1 to limit the homologous recombination pathway of DNA double-strand break repair in G1 phase

Cell Death and Differentiation, 2019
End resection of DNA double-strand breaks (DSBs) to form 3′ single-strand DNA (ssDNA) is critical to initiate the homologous recombination (HR) pathway of DSB repair.
Ying Xie, Yike Liu, Zongpei Guo, H. Guan, Xiao-dan Liu, Dafei Xie, Yiguo Jiang, Teng Ma, P. Zhou   +8 more
semanticscholar   +1 more source

Attachment of HeLa cells during early G1 phase [PDF]

Histochemistry and Cell Biology, 2011
Both growth factor directed and integrin dependent signal transduction were shown to take place directly after completion of mitosis. The local activation of these signal transduction cascades was investigated in early G1 cells. Interestingly, various key signal transduction proteins were found in blebs at the cell membrane within 30 min after mitosis.
Moes, M.J.A., Bijvelt, J.J.M., Boonstra, J.   +2 more
openaire   +3 more sources

Induction of G1-phase cell cycle arrest and apoptosis pathway in MDA-MB-231 human breast cancer cells by sulfated polysaccharide extracted from Laurencia papillosa

Cancer Cell International, 2016
Marine algae consumption is linked to law cancer incidences in countries that traditionally consume marine products. Hence, Phytochemicals are considered as potential chemo-preventive and chemotherapeutic agents against cancer.
Hossam Murad, Mohammad Hawat, Adnan M. Ekhtiar, Abdulmunim Aljapawe, A. Abbas, Hussein Darwish, Oula Sbenati, A. Ghannam   +7 more
semanticscholar   +1 more source

Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions

Nature Communications, 2022
Reusswig et al. use engineered systems to force DNA replication in the G1 phase of the cell cycle. This unscheduled G1 replication shows hallmarks of S phase replication, but leads to over-replication and DNA breaks from replication collisions.
Karl-Uwe Reusswig, Julia Bittmann, Martina Peritore, Mathilde Courtes, Benjamin Pardo, Michael Wierer, Matthias Mann, Boris Pfander   +7 more
doaj   +1 more source

Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study [PDF]

, 2019
Background: Dry eye disease (DED) affects more than 14% of the elderly population causing decrease of quality of life, high costs and vision impairment.
Allegretti, M., Ferrari, M., Garhoefer, G., Lambiase, A., Mantelli, F., Sacchetti, M., Schmetterer, L., Schmidl, D.   +7 more
core   +1 more source