Results 51 to 60 of about 7,531,916 (333)

Cell Cycle-Dependent Expression Dynamics of G1/S Specific Cyclin, Cellulose Synthase and Cellulase in the Dinoflagellate Prorocentrum donghaiense

Frontiers in Microbiology, 2017
Dinoflagellates undergo a typical eukaryotic cell cycle consisting of G1, S, G2, and M phases and some of the typical cell cycle related genes have been computationally identified.
Xinguo Shi, Minglei Ma, Senjie Lin, Senjie Lin   +3 more
doaj   +1 more source

The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells [PDF]

, 2007
Background/Aim: Tumors exhibiting constitutively activated PI(3) K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including
Albert JM, Auernhammer CJ, Boulay A, Boulay A, Bousquet C, Burkhard Göke, Cao C, Christoph J. Auernhammer, Enrico N. De Toni, Faivre S, Gerald Spöttl, Grewe M, Heinrich H.D. Meyer, Hosoi H, Jeng YJ, Jennifer Meinecke, Kathrin Zitzmann, Kawamata S, Kirchner GI, Luo J, O?Reilly KE, Oberg K, Ramage JK, Sawyers CL, Shah T, Shaw RJ, Stephan Brand, Sun SY, Vignot S, von Wichert G, Wang L, Wanner K, Wendel HG, Wullschleger S, Yao JC, Yee KW   +35 more
core   +1 more source

Glycyrrhetinic acid induces G1-phase cell cycle arrest in human non-small cell lung cancer cells through endoplasmic reticulum stress pathway

International Journal of Oncology, 2015
Glycyrrhetinic acid (GA) is a natural compound extracted from liquorice, which is often used in traditional Chinese medicine. The purpose of the present study was to investigate the antitumor effect of GA in human non-small cell lung cancer (NSCLC), and ...
Jie Zhu, Meijuan Chen, N. Chen, Ai-jing Ma, Chunyan Zhu, Ruo-lin Zhao, Miao Jiang, Jing Zhou, L. Ye, H. Fu, Xu Zhang   +10 more
semanticscholar   +1 more source

Strategic cell-cycle regulatory features that provide mammalian cells with tunable G1 length and reversible G1 arrest.

PLoS ONE, 2012
Transitions between consecutive phases of the eukaryotic cell cycle are driven by the catalytic activity of selected sets of cyclin-dependent kinases (Cdks).
Benjamin Pfeuty
doaj   +1 more source

Two pathways recruit telomerase to Saccharomyces cerevisiae telomeres. [PDF]

PLoS Genetics, 2008
The catalytic subunit of yeast telomerase, Est2p, is a telomere associated throughout most of the cell cycle, while the Est1p subunit binds only in late S/G2 phase, the time of telomerase action.
Angela Chan, Jean-Baptiste Boulé, Virginia A Zakian   +2 more
doaj   +1 more source

Orc1 Binding to Mitotic Chromosomes Precedes Spatial Patterning during G1 Phase and Assembly of the Origin Recognition Complex in Human Cells*

Journal of Biological Chemistry, 2015
Background: Orc1 is the largest subunit of the origin recognition complex that promotes genome duplication. Results: We studied the dynamics of Orc1 during the cell division cycle. Conclusion: Orc1 binds to mitotic chromosomes, and during G1 phase in the
Nihan Kara, Manzar Hossain, S. Prasanth, B. Stillman   +3 more
semanticscholar   +1 more source

Double-negative feedback between S-phase cyclin-CDK and CKI generates abruptness in the G1/S switch

Frontiers in Physiology, 2012
The G1/S transition is a crucial decision point in the cell cycle. At G1/S, there is an abrupt switch from a state of high CDK inhibitor (CKI) levels and low S-phase CDK activity to a state of high S-phase CDK activity and degraded CKI. In budding yeast,
Rainis eVenta, Ervin eValk, Mardo eKõivomägi, Mart eLoog   +3 more
doaj   +1 more source

Cell cycle features of primate embryonic stem cells. [PDF]

, 2005
International audienceUsing flow cytometry measurements combined with quantitative analysis of cell cycle kinetics, we show that rhesus monkey embryonic stem cells (ESCs) are characterized by an extremely rapid transit through the G1 phase, which ...
Dehay, Colette, Fluckiger, Anne-Catherine, François-Loïc, Cosset, Marchand, Mélanie, Marcy, Guillaume, Mitalipov, Shoukhrat, Negre, Didier, Savatier, Pierre, Wolf, Don   +8 more
core   +3 more sources

53BP1 promotes microhomology-mediated end-joining in G1-phase cells

Nucleic Acids Research, 2015
Alternative non-homologous end joining (alt-NHEJ) was originally identified as a backup repair mechanism in the absence of classical NHEJ (c-NHEJ) factors but recent studies have demonstrated that alt-NHEJ is active even when c-NHEJ as well as homologous
Xiahui Xiong, Zhanwen Du, Ying Wang, Zhihui Feng, Pan Fan, Chunhong Yan, H. Willers, Junran Zhang   +7 more
semanticscholar   +1 more source

Germinating fission yeast spores delay in G1 in response to UV irradiation

BMC Cell Biology, 2004
Background Checkpoint mechanisms prevent cell cycle transitions until previous events have been completed or damaged DNA has been repaired. In fission yeast, checkpoint mechanisms are known to regulate entry into mitosis, but so far no checkpoint ...
Vebø Heidi, Tvegård Tonje, Synnes Marianne, Nilssen Esben A, Boye Erik, Grallert Beáta   +5 more
doaj   +1 more source