Results 61 to 70 of about 7,531,916 (333)

The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo- and imino-pyridine anticancer complexes : control of cell selectivity, cross-resistance, p53 dependence, and apoptosis pathway [PDF]

, 2013
Organometallic half-sandwich complexes [M(p-cymene)(azo/imino-pyridine)X]+ where M = RuII or OsII and X ═ Cl or I, exhibit potent antiproliferative activity toward a range of cancer cells.
Romero-Canelón, Isolda, Sadler, P. J., Salassa, Luca   +2 more
core   +1 more source

A retinoblastoma orthologue is a major regulator of S-phase, mitotic, and developmental gene expression in Dictyostelium. [PDF]

PLoS ONE, 2012
The retinoblastoma tumour suppressor, Rb, has two major functions. First, it represses genes whose products are required for S-phase entry and progression thus stabilizing cells in G1.
Kimchi Strasser, Gareth Bloomfield, Asa MacWilliams, Adriano Ceccarelli, Harry MacWilliams, Adrian Tsang   +5 more
doaj   +1 more source

Transfection-Mediated Cell Synchronization: Acceleration of G1-S Phase Transition by Gamma Irradiation

BioTechniques, 2001
We have previously provided evidence that the uptake of DNA into cells is cell cycle specific following transfection. We show here that, immediately after transfection, successfully transfected cells are greatly enriched for cells in early G1 or G0 phase
Eun Joo Jung, Erik K. Flemington
doaj   +1 more source

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication [PDF]

, 2015
© 2015, Chang et al.To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly.
Speck, C
core   +1 more source

SNAILs promote G1 phase in selected cancer cells

International Journal of Oncology, 2015
Cells can acquire a stem-like cell phenotype through epithelial-mesenchymal transition (EMT). However, it is not known which of the stem-like cancer cells are generated by these phenotype transitions. We studied the EMT-inducing roles of SNAILs (the key inducers for the onset of EMT) in selected cancer cells (lung cancer cell line with relatively ...
Ya-Lan, Wu, Jian-Xin, Xue, Lin, Zhou, Lei, Deng, Yan-Na, Shang, Fang, Liu, Xian-Ming, Mo, You, Lu   +7 more
openaire   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Direct repression of cyclin d1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition [PDF]

, 2007
Zinc finger transcription factors of the Snail/Slug and ZEB-1/SIP1 families control epithelial-mesenchymal transitions in development in cancer. Here, we studied SIP1-regulated mesenchymal conversion of epidermoid A431 cells.
Jakob Mejlvang, Marina Kriajevska, Cindy Vandewalle, Tatyana Chernova, A. Emre Sayan, Geert Berx, J. Kilian Mellon, Eugene Tulchinsky, Ben Margolis, Aigner K., Andersen H., Batlle E., Berx G., Blanco M. J., Bolos V., Brockbank E. C., Burstyn-Cohen T., Cano A., Carver E., Christofori G., Comijn J., De Craene B., De Craene B., Dohadwala M., Eger A., Elloul S., Franci C., Furusawa T., Guilford P., Imamichi Y., Imai T., Jiang R., Jorda M., Krishnamachary B., Knudsen K. E., Lin S., Lochter A., Maeda G., Malumbres M., McGarry L., Mejlvang J., Moreno-Bueno G., Murray S., Ohkubo T., Patrone G., Peinado H., Perez-Moreno M. A., Postigo A., Remacle J., Rosivatz E., Shy Y., Spoelstra N., Sugimachi K., Taki M., Thiery J. P., Thiery J. P., Turner F., van de Putte T., van Grunsven L. A., van Grunsven L. A., Vandewalle C., Vega S., Walker J. L., Walker J. L., Zhou B. P.   +64 more
core   +2 more sources

Induction of S phase by G1 regulatory factors [PDF]

Frontiers in Bioscience, 1999
The first gap phase (G1) in the mammalian cell cycle plays a pivotal role in determining whether or not cells are to initiate DNA replication. Progression through G1 phase and transition into S phase are positively and negatively regulated by a series of factors, collectively termed G1 regulators.
openaire   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Niclosamide Induces Cell Cycle Arrest in G1 Phase in Head and Neck Squamous Cell Carcinoma Through Let-7d/CDC34 Axis

Frontiers in Pharmacology, 2019
Niclosamide is a traditional anti-tapeworm drug that exhibits potent anti-cancer activity. Our previous study showed that niclosamide induces cell cycle arrest in G1 phase. Nevertheless, the underlying mechanism remains unknown.
Zewen Han, Qingxiang Li, Yifei Wang, Lin Wang, Xiaoxu Li, Na Ge, Yixiang Wang, Chuanbin Guo   +7 more
doaj   +1 more source