Results 71 to 80 of about 7,531,916 (333)

Sensitivity of yeast strains with long G-tails to levels of telomere-bound telomerase. [PDF]

PLoS Genetics, 2007
The Saccharomyces cerevisiae Pif1p helicase is a negative regulator of telomere length that acts by removing telomerase from chromosome ends. The catalytic subunit of yeast telomerase, Est2p, is telomere associated throughout most of the cell cycle, with
Leticia R Vega, Jane A Phillips, Brian R Thornton, Jennifer A Benanti, Mutiat T Onigbanjo, David P Toczyski, Virginia A Zakian   +6 more
doaj   +1 more source

Cell Cycle Status Influences Resistance to Apoptosis Induced by Oxidative Stress in Human Breast Cancer Cells, Which Is Accompanied by Modulation of Autophagy

Current Issues in Molecular Biology, 2023
Cancer cells are characterised by uncontrolled cell proliferation; however, some of them can temporarily arrest their cell cycle at the G0 or G1 phase, which could contribute to tumour heterogeneity and drug resistance.
Magdalena Kluska, Agnieszka Wanda Piastowska-Ciesielska, Paulina Tokarz   +2 more
doaj   +1 more source

Piperine Causes G1 Phase Cell Cycle Arrest and Apoptosis in Melanoma Cells through Checkpoint Kinase-1 Activation

PLoS ONE, 2014
In this study, we determined the cytotoxic effects of piperine, a major constituent of black and long pepper in melanoma cells. Piperine treatment inhibited the growth of SK MEL 28 and B16 F0 cells in a dose and time-dependent manner.
Neel M. Fofaria, Sung-Hoon Kim, S. Srivastava   +2 more
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Different Donor Cell Culture Methods Can Influence the Developmental Ability of Cloned Sheep Embryos. [PDF]

PLoS ONE, 2015
It was proposed that arresting nuclear donor cells in G0/G1 phase facilitates the development of embryos that are derived from somatic cell nuclear transfer (SCNT).
LiBing Ma, XiYu Liu, FengMei Wang, XiaoYing He, Shan Chen, WenDa Li   +5 more
doaj   +1 more source

Time Course of PR of UV-Induced Chromosomal Aberrations and Lethal Damage in G1 Xenopus Cells [PDF]

, 1977
Synchronous cultures of early G1 cells were exposed to UV and their ability to photoreactivate lethal and aberrational damage was determined as a function of time following UV exposure.
Griggs, H. Gaston, Payne, Jan
core   +2 more sources

Unscheduled DNA synthesis after partial UV irradiation of the cell nucleus [PDF]

, 1979
Cells of an euploid strain of the Chinese hamster synchronized in the G1 phase were microirradiated in the nucleus with a laser UV microbeam (λ = 257 nm) and pulse-labelled with [3H]thymidine. In autoradiographs of cells fixed immediately after the pulse
Berliner, Bostock, Brown, Christian Zorn, Christoph Cremer, Cleaver, Cohen, Comings, Cremer, Cremer, Cremer, Cremer, Deaven, Diaz, Dutrillaux, Ehmann, Feldman, Ghosh, Godin, Harris, Heneen, Hens, Hobarth, Hsu, Johnson, Juricek, Jürgen Zimmer, Loza Bonifaz, Moreno, Moreno, Nichols, Rasmussen, Robards, Sakharov, Sakharov, Schempp, Schwarzacher, Singh, Thomas Cremer, Vogel, Warburton, Werry, Wilkins, Williams, Yatani, Zorn, Zorn, Zorn   +47 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Emergent properties of the G1/S network [PDF]

, 2010
Tato práce se zabývá buněčným cyklem kvasinky Saccgaromyces cerevisiae. Oblastí našeho zájmu je přechod mezi G1 a S fází, kde je naším cílem identifikovat velikosti buňky v době počátku DNA replikace.
Dražková, Jana
core