Results 201 to 210 of about 7,531,916 (333)

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

FEN1 is critical for rapid single-strand break repair in G1 phase. [PDF]

Nucleic Acids Res
Burdova K, Hailstone R, Hanzlikova H, Caldecott KW.   +3 more
europepmc   +1 more source

RAD51 Inhibition Induces R-Loop Formation in Early G1 Phase of the Cell Cycle. [PDF]

Int J Mol Sci, 2021
Nascakova Z, Boleslavska B, Urban V, Oravetzova A, Vlachova E, Janscak P, Dobrovolna J.   +6 more
europepmc   +1 more source

Problems and applications of cell cycle analysis: Distinguishing G0 From G1 and G1 From S Phase [PDF]

Cytometry, 1988
Stout, Robert D., Suttles, Jill
openaire   +3 more sources

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase. [PDF]

Adv Sci (Weinh)
Guo L, Lin J, Ren Q, Sun H, Wu Y, Ge H, Wu X, Lin L, Liang L, Li C, Liu H, Mai Y, Chu S, Liu J, Liu J, Chen J, Pei D, Zheng H.   +17 more
europepmc   +1 more source

Learnable Diffusion Framework for Mouse V1 Neural Decoding

Advanced Science, EarlyView.
We introduce Sensorium‐Viz, a diffusion‐based framework for reconstructing high‐fidelity visual stimuli from mouse primary visual cortex activity. By integrating a novel spatial embedding module with a Diffusion Transformer (DiT) and a synthetic‐response augmentation strategy, our model outperforms state‐of‐the‐art fMRI‐based baselines, enabling robust
Kaiwen Deng, Peter S. Schwendeman, Yuanfang Guan   +2 more
wiley   +1 more source

Synthesis and Anti-Hepatoma Activities of U12 Derivatives Arresting G0/G1 Phase and Inducing Apoptosis by PI3K/AKT/mTOR Pathway. [PDF]

Pharmaceuticals (Basel), 2022
Yang R, Du C, Cao T, Wang G, Jiang X, Gao J, Lin T, Sun C, Ding R, Tian W, Chen H.   +10 more
europepmc   +1 more source

Lengthened G1 Phase Indicates Differentiation Status in Human Embryonic Stem Cells

Stem Cells and Development, 2013
Ashley N. Calder, Ivana Roth-Albin, Sonam Bhatia, C. Pilquil, Jong Hee Lee, M. Bhatia, M. Levadoux-Martin, Jamie D. McNicol, Jennifer Russell, Tony J. Collins, J. Draper   +10 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source