Results 211 to 220 of about 7,531,916 (333)

PPP1R12B inhibits cell proliferation by inducing G0/G1 phase arrest via PAK2/β-catenin axis in hepatocellular carcinoma. [PDF]

Front Cell Dev Biol
Zhang Y, Liu S, Bai M, Zhao Z, Wang S, Bao M, Bao J, Shen S, Lu S, Xiong Y, Gu G, Wang H, Chen L.   +12 more
europepmc   +1 more source

Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle. [PDF]

ACS Omega, 2021
Delgado M, Washam CL, Urbaniak A, Heflin B, Storey AJ, Lan RS, Mackintosh SG, Tackett AJ, Byrum SD, Chambers TC.   +9 more
europepmc   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Loss of G1-phase CDK-inhibition biases instability between genomic regions by unevenly reducing activity among replication origins. [PDF]

iScience
Gomes F, Devesa F, Ayuda-Durán P, Aza P, Agote-Arán A, Cavero D, Embarc-Buh A, González A, Bermejo R, Calzada A.   +9 more
europepmc   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Extending the G1 phase improves the production of lipophilic compounds in yeast by boosting enzyme expression and increasing cell size. [PDF]

Proc Natl Acad Sci U S A
Hao H, Yao M, Wang Y, Zhang C, Liu Z, Nielsen J, Shi S, Xiao W, Yuan Y.   +8 more
europepmc   +1 more source

Aqueous Extract and Polysaccharide of Aconiti Lateralis Radix Induce Apoptosis and G0/G1 Phase Cell Cycle Arrest by PI3K/AKT/mTOR Signaling Pathway in Mesangial Cells. [PDF]

Evid Based Complement Alternat Med, 2022
Li X, An P, Zhao Y, Cai Z, Ye B, Wang Y, Wang W, Gao Q, Li L, Zhang T, Wu X.   +10 more
europepmc   +1 more source

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

NR4A3 inhibits the tumor progression of hepatocellular carcinoma by inducing cell cycle G0/G1 phase arrest and upregulation of CDKN2AIP expression. [PDF]

Int J Biol Sci
Zhao X, Min X, Wang Z, Chen X, Ge C, Zhao F, Tian H, Chen T, Li J.   +8 more
europepmc   +1 more source