Results 271 to 280 of about 7,531,916 (333)

Mesoporous Silica Nanoparticles With Customized Drug Ratio/Loading for Effective Treatment of Gemcitabine‐Resistant Pancreatic Tumors

Advanced NanoBiomed Research, EarlyView.
Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq, Sudip Kumar Dam, Doaha Awad, Punnya Anil Kumar Jeeja, Farzana Ferdous, Juan L. Vivero‐Escoto   +5 more
wiley   +1 more source

UHRF2 accumulates in early G₁-phase after serum stimulation or mitotic exit to extend G₁ and total cell cycle length. [PDF]

Cell Cycle
Wang X, Lu H, Sprangers G, Hallstrom TC.
europepmc   +1 more source

Standardized <i>Pluchea Indica</i> Leaf Extract Exhibited Antiproliferative Activity Against TGF-β-induced Prostate Stromal Cells (WPMY-1) Through G 1 Phase Cell Cycle Arrest <i>via</i> SMAD2/3 and ERK1/2 Signaling Pathways. [PDF]

In Vivo
Kanphet Y, Uttarawichien T, Vongsak B, Boonsom T, Nalinratana N, Sivaji S, Towiwat P, Sukrong S.   +7 more
europepmc   +1 more source

Functional models from limited data: A parametric and multimodal approach to anatomy and 3D kinematics of feeding in basking sharks (Cetorhinus maximus)

The Anatomical Record, EarlyView.
Abstract Basking sharks, Cetorhinus maximus (Gunnerus, Brugden [Squalus maximus], Det Kongelige Norske Videnskabers Selskabs Skrifter, 1765, vol. 3, pp. 33–49), feed by gaping their mouths and gill slits, greatly reorienting their cranial skeletons to filter food from water.
Tairan Li, Mike Schindler, Martha Paskin, Venkata A. Surapaneni, Elliott Scott, Sabine Hauert, Nicholas Payne, David E. Cade, Jeremy A. Goldbogen, Frederik H. Mollen, Daniel Baum, Sean Hanna, Mason N. Dean   +12 more
wiley   +1 more source

Longitudinal Modulation of the Gut Microbiome and Growth Performance by Phytochemicals as Antibiotic Alternatives in Swine Production

Animal Research and One Health, EarlyView.
We conducted a longitudinal trial across nursery, growing, and finishing phases, showing that phytochemical supplementation as a potential antibiotic alternative reduced potential pathogens and promoted beneficial Lactobacillus amylovorus in the nursery phase, and enriched amino acid and carbohydrate metabolism pathways (prediction) during finishing ...
Ziyu Liu, Samantha Howe, Yang Tian, Alisun N. Watson, Jason E. Farrar, Christopher E. Randolph, Jaime Andrés Ángel Isaza, Álvaro José Uribe, Yan Huang, Michael Looper, Jiangchao Zhao, Tsungcheng Tsai   +11 more
wiley   +1 more source

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G1 phase progression: cycling on cue.

Cell, 1994
Charles J. Sherr Howard Hughes Medical Institute Department of Tumor Cell Biology St. Jude Children’s Research Hospital 332 North Lauderdale Memphis, Tennessee 38104 Recent advances in our understanding of the cell division cycle are now tying the functions of Gl phase regulators to diverse processes involving signal transduction, differ- entiation ...
C. Sherr
semanticscholar   +3 more sources

Yeast G1 cyclins are unstable in G1 phase

Nature, 1998
In most eukaryotes, commitment to cell division occurs in late G1 phase at an event called Start in the yeast Saccharomyces cerevisiae, and called the restriction point in mammalian cells. Start is triggered by the cyclin-dependent kinase Cdc28 and three rate-limiting activators, the G1 cyclins Cln1, Cln2 and Cln3.
B L, Schneider, E E, Patton, S, Lanker, M D, Mendenhall, C, Wittenberg, B, Futcher, M, Tyers   +6 more
openaire   +2 more sources

Molecular cloning of G1 phase mRNAs from a subtractive G1 phase cDNA library

Biochemistry and Cell Biology, 1993
Many G1-phase-specific mRNAs have been identified from various normal or transformed cells based on serum induction and re-entry into the cell cycle from quiescence. However, these mRNAs may not represent some important genes expressed during G1 phase in continuously cycling cells.
G, Wu, S, Su, T Y, Kung, R C, Bird
openaire   +2 more sources

Regulation of G1 Phase

1998
The cell cycle describes the ordered process by which a cell executes the four essential tasks required to produce a duplicate of itself: growth (increase in mass), chromosomal duplication, chromosomal segregation, and cellular division (Mitchison 1971).
R J, Sheaff, J M, Roberts
openaire   +2 more sources

Cell fate determination during G1 phase progression

Cellular and Molecular Life Sciences, 2007
During the cell cycle, a cell may encounter one of five different fates: it can proliferate, differentiate, become quiescent or senescent, or go into apoptosis. The initiation of such fates is often seen in the G1 phase. The aim of this review is to describe an integrative model of G1 phase progression and cell fate determination.
V A, Blomen, J, Boonstra
openaire   +2 more sources