Results 281 to 290 of about 7,531,916 (333)

G1 Phase: Components, Conundrums, Context

2006
A eukaryotic cell must coordinate DNA synthesis and chromosomal segregation to generate a faithful replica of itself. These events are confined to discrete periods designated synthesis (S) and mitosis (M), and are separated by two gap periods (Gl and G2). A complete proliferative cycle entails sequential and regulated progression through G1, S, G2, and
Stephanie J, Moeller, Robert J, Sheaff
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Inhibition of cellular transition from G1-resting to G1-prereplicative phase by aminonucleoside or puromycin

In Vitro, 1979
Human embryonic lung fibroblasts (IMR-90 and WI-38) were arrested in the G1 phase of the cell cycle by serum deprivation and high population density. Within 1 hr after the addition of medium containing fresh serum, these cells showed an increase in rRNA synthesis.
J J, Cholon, R G, Knopf, R M, Pine
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Expression of G1-Phase Cell Cycle Genes during Hematopoietic Lineage

Biochemical and Biophysical Research Communications, 1997
Characterization of proteins that control the passage through the G1 phase of the cell cycle is of particular interest because virtually all stimuli regulating cell proliferation or differentiation act primarily during this phase. We have analyzed the G1 phase proteic machinery, including cyclin D types, cyclin-dependent kinases (CDKs) and CDK ...
DELLA RAGIONE, Fulvio, BORRIELLO, Adriana, MASTROPIETRO S, DELLA PIETRA V, MONNO F, GABUTTI V, LOCATELLI F, BONSI L, BAGNARA GP, IOLASCON A.   +9 more
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Deoxyadenosine Induced G1 Phase Arrest in Leukemic T Cells

1984
The recognition that human combined immune deficiency is associated with inborn adenosine deaminase (ADA) deficiency has focused attention on the importance of purine nucleoside metabolism and toxicity in the lymphoid system1. This has been reinforced by the development of drugs which inhibit ADA, in particular deoxy-coformycin (DCF), now used in the ...
R M, Fox, E H, Tripp, I W, Taylor
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Calcium oscillations, G1 phase duration and neurogenesis timing

Trends in Cell Biology, 2010
We read with interest the excellent review by Salomoni and Calegari on the effects of G1 phase duration on the developmental behavior of neural stem cells [1xCell cycle control of mammalian neural stem cells: putting a speed limit on G1. Salomoni, P. and Calegari, F. Trends Cell Biol.
Michael G. Lenos, Sofia-Maria Tsaniklidou   +1 more
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G1 phase heterogeneity in exponentially growing Swiss 3T3 mouse fibroblasts

Experimental Cell Research, 1984
The growth rate of normal cultured Swiss 3T3 fibroblasts is function of serum concentration and the fraction of G1 cells, and hence the average residence time in G1, increases with the generation time. Serum contains two sets of factors: competence factors, essentially platelet-derived growth factor (PDGF), which induces competence in quiescent ...
E, Sturani, L, Toschi, R, Zippel, E, Martegani, L, Alberghina   +4 more
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Cdc2–cyclin E complexes regulate the G1/S phase transition

Nature Cell Biology, 2005
The cyclin-dependent kinase inhibitor p27(Kip1) is known as a negative regulator of cell-cycle progression and as a tumour suppressor. Cdk2 is the main target of p27 (refs 2, 3) and therefore we hypothesized that loss of Cdk2 activity should modify the p27(-/-) mouse phenotype. Here, we show that although p27(-/-) Cdk2(-/-) mice developed ovary tumours
Eiman, Aleem, Hiroaki, Kiyokawa, Philipp, Kaldis   +2 more
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Parafibromin inhibits cancer cell growth and causes G1 phase arrest

Biochemical and Biophysical Research Communications, 2006
The HRPT2 (hereditary hyperparathyroidism type 2) tumor suppressor gene encodes a ubiquitously expressed 531 amino acid protein termed parafibromin. Inactivation of parafibromin predisposes one to the development of HPT-JT syndrome. To date, the role of parafibromin in tumorigenesis is largely unknown.
Chun, Zhang, Dong, Kong, Min-Han, Tan, Donald L, Pappas, Peng-Fei, Wang, Jindong, Chen, Leslie, Farber, Nian, Zhang, Han-Mo, Koo, Michael, Weinreich, Bart O, Williams, Bin Tean, Teh   +11 more
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G1 and S-Phase Checkpoints, Chromosome Instability, and Cancer

2004
Mitogen-dependent progression through the first gap phase (G1) of the mammalian cell-division cycle is precisely regulated so that normal cell division is coordinated with cell growth, while the initiation of DNA synthesis (S phase) is precisely ordered to prevent inappropriate amplification of the DNA that may cause genome instability.
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Mammalian G1 and G2 phase checkpoints.

Cancer surveys, 1997
This present review explores the mechanisms for DNA damage induced G1 and G2 arrest in mammalian cells. The complexity of the TP53 pathway is attested to by the variety of genes regulated by TP53, many of which require further investigation to bring their importance into focus. One gene intensely studied, p21, has been linked to the G1 arrest mechanism
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