Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery [PDF]
Nature Communications, 2018 DNA damage induces checkpoints to ensure that damage is not transferred to the next generation, but the molecular pathways responsible for checkpoint recovery are not clear.
Hui-Ju Hsieh +11 more
doaj +7 more sources
Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: computational modeling and analysis. [PDF]
NPJ Syst Biol Appl, 2021 Different cancer cell lines can have varying responses to the same perturbations or stressful conditions. Cancer cells that have DNA damage checkpoint-related mutations are often more sensitive to gene perturbations including altered Plk1 and p53 ...
Jung Y +4 more
europepmc +8 more sources
PBAF loss leads to DNA damage-induced inflammatory signaling through defective G2/M checkpoint maintenance [PDF]
Genes & Development, 2022 Here, Feng et al. investigated the molecular mechanisms underlying the responses to immunotherapy in renal cancer by loss of PBRM1, a subunit of the PBAF (SWI/SNF) chromatin remodeling complex mutated in ∼40% of clear cell renal cancers.
Hugang Feng +6 more
semanticscholar +5 more sources
The Protein Kinase Cδ Catalytic Fragment Is Critical for Maintenance of the G2/M DNA Damage Checkpoint [PDF]
Journal of Biological Chemistry, 2009 Protein kinase Cδ (PKCδ) is an essential component of the intrinsic apoptotic program. Following DNA damage, such as exposure to UV radiation, PKCδ is cleaved in a caspase-dependent manner, generating a constitutively active catalytic fragment (PKCδ-cat),
Edward L. LaGory +2 more
semanticscholar +5 more sources
Cdk5 Activator-binding Protein C53 Regulates Apoptosis Induced by Genotoxic Stress via Modulating the G2/M DNA Damage Checkpoint [PDF]
Journal of Biological Chemistry, 2005 In response to DNA damage, the cellular decision of life versus death involves an intricate network of multiple factors that play critical roles in regulation of DNA repair, cell cycle, and cell death.
Hai Jiang, Shouqing Luo, Honglin Li
semanticscholar +5 more sources
The G2/M DNA damage checkpoint inhibits mitosis through Tyr15 phosphorylation of p34cdc2 in Aspergillus nidulans [PDF]
The EMBO Journal, 1997 It is possible to cause G2 arrest in Aspergillus nidulans by inactivating either p34cdc2 or NIMA. We therefore investigated the negative control of these two mitosis-promoting kinases after DNA damage. DNA damage caused rapid Tyr15 phosphorylation of p34cdc2 and transient cell cycle arrest but had little effect on the activity of NIMA.
Xiayan Ye
semanticscholar +5 more sources
Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity [PDF]
Journal of Biological Chemistry, 2000 Recent evidence indicates that arrest of mammalian cells at the G(2)/M checkpoint involves inactivation and translocation of Cdc25C, which is mediated by phosphorylation of Cdc25C on serine 216. Data obtained with a phospho-specific antibody against serine 216 suggest that activation of the DNA damage checkpoint is accompanied by an increase in serine ...
Bin‐Bing S. Zhou +8 more
semanticscholar +6 more sources
JNK-mediated Phosphorylation of Cdc25C Regulates Cell Cycle Entry and G2/M DNA Damage Checkpoint [PDF]
Journal of Biological Chemistry, 2010 c-Jun NH2-terminal Kinases (JNKs) play a central role in the cellular response to a wide variety of stress signals. After their activation, JNKs induce phosphorylation of substrates, which control proliferation, migration, survival, and differentiation ...
Gustavo J. Gutierrez +6 more
semanticscholar +7 more sources
Cinobufagin-induced DNA damage response activates G2/M checkpoint and apoptosis to cause selective cytotoxicity in cancer cells [PDF]
Cancer Cell International, 2021 Background Processed extracts from toad skin and parotoid gland have long been used to treat various illnesses including cancer in many Asian countries. Recent studies have uncovered a family of bufadienolides as the responsible pharmacological compounds,
Jiajing Niu +4 more
semanticscholar +7 more sources
Elevated Cyclin G2 Expression Intersects with DNA Damage Checkpoint Signaling and Is Required for a Potent G2/M Checkpoint Arrest Response to Doxorubicin [PDF]
Journal of Biological Chemistry, 2012 Background: DNA damage triggers cell cycle checkpoints to halt cell division ahead of DNA repair. Results: Ectopic cyclin G2 (CycG2) induces a Chk2-dependent cell cycle arrest, and depletion of endogenous CycG2 attenuates doxorubicin-induced G2/M-phase ...
Maike Zimmermann +5 more
semanticscholar +5 more sources