Results 81 to 90 of about 57,844 (267)

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Negative regulation of G2-M by ATR (mei-41)/Chk1(Grapes) facilitates tracheoblast growth and tracheal hypertrophy in Drosophila

eLife, 2018
Imaginal progenitors in Drosophila are known to arrest in G2 during larval stages and proliferate thereafter. Here we investigate the mechanism and implications of G2 arrest in progenitors of the adult thoracic tracheal epithelium (tracheoblasts).
Amrutha Kizhedathu, Archit V Bagul, Arjun Guha   +2 more
doaj   +1 more source

Present and Future Perspective on PLK1 Inhibition in Cancer Treatment

Frontiers in Oncology, 2022
Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine kinase family. PLK1 has a key role in the progression of mitosis and recent evidence suggest its important involvement in regulating the G2/M checkpoint, in DNA ...
Michela Chiappa, Serena Petrella, Giovanna Damia, Massimo Broggini, Federica Guffanti, Francesca Ricci   +5 more
doaj   +1 more source

Toxic Effect of Silica Nanoparticles on Endothelial Cells through DNA Damage Response via Chk1-Dependent G2/M Checkpoint

PLoS ONE, 2013
Silica nanoparticles have become promising carriers for drug delivery or gene therapy. Endothelial cells could be directly exposed to silica nanoparticles by intravenous administration. However, the underlying toxic effect mechanisms of silica nanoparticles on endothelial cells are still poorly understood.
Junchao Duan, Yongbo Yu, Yang Li, Yang Yu, Yanbo Li, Xianqing Zhou, Peili Huang, Zhiwei Sun   +7 more
openaire   +4 more sources

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Abrogating the G2/M checkpoint with PROTACs to enhance DNA damaging therapies

Head and neck squamous cell carcinoma (HNSCC) incidence is expected to increase by 30% by 2030. Whilst rare, the five-year survival rate for HNSCC patients is only 50%, with tumours often resistant to genotoxic treatments. Survival data shows that the current treatment modality is ineffective, thus, it is critical to find targets for combinatorial ...
Buckley-Benbow, Lauryn, Allinson, Sarah, Fielding, Andrew, Parsons, Jason L., Gadd, Morgan   +4 more
openaire   +3 more sources

Mouse zygotes respond to severe sperm DNA damage by delaying paternal DNA replication and embryonic development. [PDF]

PLoS ONE, 2013
Mouse zygotes do not activate apoptosis in response to DNA damage. We previously reported a unique form of inducible sperm DNA damage termed sperm chromatin fragmentation (SCF).
Joanna E Gawecka, Joel Marh, Michael Ortega, Yasuhiro Yamauchi, Monika A Ward, W Steven Ward   +5 more
doaj   +1 more source

SUMOylation inhibits FOXM1 activity and delays mitotic transition [PDF]

, 2014
The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but
Brosens, Jan J., Coombes, R. C., Dunsby, C. W., French, P. M., Gomes, Ana R., Karunarathna, U., Kelly, D. J., Khongkow, P., Kongsema, M., Lam, Eric W.-F., Langer, J. K., Man, Cornelia W-Y., Myatt, Stephen S., Zona, Stefania   +13 more
core   +1 more source

Ataxia Telangiectasia-mutated- and Rad3-related Protein Regulates the DNA Damage-induced G2/M Checkpoint through the Aurora A Cofactor Bora Protein [PDF]

Journal of Biological Chemistry, 2013
Polo-like kinase1 (Plk1) activation is inhibited in response to DNA damage, and this inhibition contributes to the activation of the G2/M checkpoint, although the molecular mechanism by which Plk1 is inhibited is not clear. Here we report that the DNA damage signaling pathway inhibits Plk1 activity through Bora.
Bo, Qin, Bowen, Gao, Jia, Yu, Jian, Yuan, Zhenkun, Lou   +4 more
openaire   +2 more sources