Results 71 to 80 of about 1,202,871 (347)

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

A Stochastic Method for Optimizing Portfolios Using a Combined Monte Carlo and Markowitz Model: Approach on Python

ECONOMICS
The main of the study is to comprehend how the mean variance efficient frontier method may be used in conjunction with Markowitz portfolio theory to produce an optimal portfolio.
Mallieswari R., Palanisamy Varadharajan, Senthilnathan Arthi Thangavelu, Gurumurthy Suganya, Joshua Selvakumar J., Pachiyappan Sathish   +5 more
doaj   +1 more source

The Keplerian orbit of G2

, 2013
We give an update of the observations and analysis of G2 - the gaseous red emission-line object that is on a very eccentric orbit around the Galaxy's central black hole and predicted to come within 2400 Rs in early 2014. During 2013, the laser guide star
Becklin, E., Boehle, A., Do, T., Ghez, A. M., Lu, J. R., Meyer, L., Morris, M. R., Phifer, K., Sitarski, B. N., Witzel, G., Yelda, S.   +10 more
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Clinical profile and outcome of Diabetic ketoacidosis in children [PDF]

Perspectives In Medical Research, 2018
Introduction: Diabetic ketoacidosis is a potentially life threatening acute complication of type 1 diabetes mellitus,characterised by triad of hyperglycemia,ketosis and acidemia,accounting for a majority of deaths related to diabetes in children ...
Harish G V1 , Panduranga G2
doaj  

Immunotherapy of Crohn's disease

Mediators of Inflammation, 1998
Although the initiating events of Crohn's disease are unknown, models of experimental colitis have provided new insights in the immunologically mediated pathways of mucosal inflammation.
C. van Montfrans, L. Camoglio, S. J. H. van Deventer   +2 more
doaj   +1 more source

Gaining Insights from Candida Biofilm Heterogeneity: One Size Does Not Fit All

Journal of Fungi, 2018
Despite their clinical significance and substantial human health burden, fungal infections remain relatively under-appreciated. The widespread overuse of antibiotics and the increasing requirement for indwelling medical devices provides an opportunistic ...
Ryan Kean, Christopher Delaney, Ranjith Rajendran, Leighann Sherry, Rebecca Metcalfe, Rachael Thomas, William McLean, Craig Williams, Gordon Ramage   +8 more
doaj   +1 more source

Facundity of Whipfin Silver Biddy Gerres filamentosus (Cuvier) from Sharavati Estuary, Central West Coast of India [PDF]

, 2011
Fecundity of Gerres filamentosus varied from 48,300to 1,16760 in fishes ranging in size from 154 to 240 mm..Fecundity increases at the rate of cube of the total length .The number of ova per gram of body weight varied from 485 to 955, while the number of
and Bhat U. G2, Renuka G1*,
core   +2 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Does the Definition of the Cost of Consumer Credit According to the Regulations Support Credit Decisions? Results of Individual In-Depth Interviews With Experts

Financial Internet Quarterly
According to the regulations in force, including in Poland, loan institutions must disclose the costs of consumer credit. However, these costs can be presented in many ways.
Cwynar Wiktor
doaj   +1 more source