Results 151 to 160 of about 1,908 (177)

Human DBR1 deficiency impairs stress granule-dependent PKR antiviral immunity. [PDF]

J Exp Med
Ru S, Tang S, Xu H, Yin J, Guo Y, Song L, Jin Z, Lee D, Chan YH, Chen X, Buerer L, Fairbrother W, Jia W, Casanova JL, Zhang SY, Gao D.   +15 more
europepmc   +1 more source

Downregulation of G3BP2 reduces atherosclerotic lesions in ApoE mice

Atherosclerosis, 2020
Atherosclerosis is mainly caused by stress in arterial microenvironments, which results in the formation of stress granules as a consequence of the stress response. As the core protein of stress granules, GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2) is known to play pivotal roles in tumour initiation, viral infection and Alzheimer's
Tianhan Li, Kang Zhang, Richard A Daniel   +2 more
exaly   +5 more sources

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway [PDF]

Nature Cell Biology, 2015
Matrix stiffness potently regulates cellular behaviour in various biological contexts. In breast tumours, the presence of dense clusters of collagen fibrils indicates increased matrix stiffness and correlates with poor survival. It is unclear how mechanical inputs are transduced into transcriptional outputs to drive tumour progression.
Spencer C Wei, Laurent Fattet, Robert L Sah   +2 more
exaly   +8 more sources

Foot-and-Mouth Disease Virus Leader Protease Cleaves G3BP1 and G3BP2 and Inhibits Stress Granule Formation [PDF]

Journal of Virology, 2019
The picornavirus foot-and-mouth disease virus (FMDV) is a notorious animal pathogen that puts a major economic burden on the global livestock industry. Outbreaks have significant consequences for animal health and product safety. Like many other viruses, FMDV must manipulate antiviral host responses to establish infection.
Gisselle N Medina, Huib H Rabouw, Raoul J De Groot   +2 more
exaly   +4 more sources

G3BP2: Structure and function

Pharmacological Research, 2022
Ras-GAP SH3 domain binding proteins (G3BPs) are a family of RNA-binding proteins that include G3BP1 and G3BP2 in mammals. The protein structure of G3BP2 allows it to bind with RNA or protein and regulate the nucleoplasmic shuttle, therefore participating in a variety of biological functions such as cell growth, differentiation and migration, and RNA ...
Jingjing Wan
exaly   +3 more sources

Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation

Neuron, 2023
Many RNA-binding proteins (RBPs), particularly those associated with RNA granules, promote pathological protein aggregation in neurodegenerative diseases. Here, we demonstrate that G3BP2, a core component of stress granules, directly interacts with Tau and inhibits Tau aggregation.
Congwei Wang, Ravi Jagasia
exaly   +4 more sources

Stress granule-associated protein G3BP2 regulates breast tumor initiation [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Malignant breast tumors consist of supporting stromal cells and epithelial cancerous cells. The cancer cell population is fueled by a reservoir of tumor-initiating cells, and these cells can give rise to the bulk of the tumor. Some breast cancer cell populations with vast proliferative potential may be intrinsically resistant to ...
Mark Badeaux, Kamila Naxerova, Dennis C Sgroi   +2 more
exaly   +3 more sources

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RIOK1 mediates p53 degradation and radioresistance in colorectal cancer through phosphorylation of G3BP2

Oncogene, 2022
RIO Kinase 1 (RIOK1) is involved in various pathologies, including cancer. However, the role of RIOK1 in radioresistance of colorectal cancer (CRC) remains largely unknown. In this study, we reported that RIOK1 was overexpressed in rectal cancer tissue with weaker tumor regression after neoadjuvant chemoradiotherapy (neoCRT).
Yaqi Chen, Sha Zhou, Kairui Wan, Long Yu, Chongchong Zhao, Haiteng Deng, Qingjian Ou, Jiayi Qin, Junbo Hu, Zhenlin Hou   +9 more
openaire   +2 more sources

G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-κB signaling pathway [PDF]

Acta Pharmacologica Sinica, 2017
The RasGAP SH3 domain-binding proteins (G3BPs) are a family of RNA-binding proteins that can co-ordinate signal transduction and post-transcriptional gene regulation. G3BPs have been shown to be involved in mediating a great diversity of cellular processes such as cell survival, growth, proliferation and apoptosis.
Jing Lu, Yu-Hong Zhang, Yi Cai
exaly   +3 more sources