Results 161 to 170 of about 1,908 (177)

FOXD1 Repression Potentiates Radiation Effectiveness by Downregulating G3BP2 Expression and Promoting the Activation of TXNIP-Related Pathways in Oral Cancer

Cancers, 2020
Radiotherapy is commonly used to treat oral cancer patients in the current clinics; however, a subpopulation of patients shows poor radiosensitivity.
Che-Hsuan Lin, Hsun-Hua Lee, Wei-Min Chang   +2 more
exaly   +2 more sources

G3BP2 regulated by the lncRNA LINC01554 facilitates esophageal squamous cell carcinoma metastasis through stabilizing HDGF transcript [PDF]

Oncogene, 2021
AbstractMetastasis is the leading cause of death of patients with esophageal squamous cell carcinoma (ESCC). Although an increasing number of studies have demonstrated the involvement of G3BP2 in several human cancers, how G3BP2 interacts with long noncoding RNAs and regulates mRNA transcripts in mediating ESCC metastasis remains unclear. In this study,
Yinli Zheng, Jinjun Wu, Ru Deng
exaly   +3 more sources

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Androgen induces G3BP2 and SUMO-mediated p53 nuclear export in prostate cancer

Oncogene, 2017
The androgen receptor (AR) has a central role in prostate cancer progression, particularly treatment-resistance disease including castration-resistant prostate cancer. Loss of the p53 tumor suppressor, a nuclear transcription factor, is also known to contribute to prostate malignancy. Here we report that p53 is translocated to the cytoplasm by androgen-
D Ashikari, K Takayama, T Tanaka, Y Suzuki, D Obinata, T Fujimura, T Urano, S Takahashi, S Inoue   +8 more
openaire   +2 more sources

Targeting G3BP2 Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment Via ELF1-MCL1 Axis

Blood, 2023
Venetoclax-based combination therapies have emerged as promising treatments for elderly acute myeloid leukemia (AML) patients. However, venetoclax resistance renders the treatment ineffective, mainly due to the upregulation of MCL1. Thus, new venetoclax-based combination therapy is under development to circumvent venetoclax resistance ...
Zhixiang Chen, Yuanhua Cai, Xiaolin Lai, Xuechun Wang, Xiongbin Yan, Yaping Wang, Fuquan Tu, Wanting Wu, Yang Li, Lili Pan, Yi Zheng, Jinggang Li, Xiaofan Li, Shaoyuan Wang   +13 more
openaire   +1 more source

α-Parvin promotes breast cancer progression and metastasis through interaction with G3BP2 and regulation of TWIST1 signaling

Oncogene, 2019
Identification of molecular alterations driving breast cancer progression is critical for the development of effective therapy. In this study, we show that the level of α-parvin is elevated in triple-negative breast cancer cells. The depletion of α-parvin from triple-negative breast cancer cells effectively inhibits breast cancer cell growth, migration,
Ying, Sun, Yanyan, Ding, Chen, Guo, Chengmin, Liu, Ping, Ma, Shuang, Ma, Zhe, Wang, Jie, Liu, Tao, Qian, Luyao, Ma, Yi, Deng, Chuanyue, Wu   +11 more
openaire   +2 more sources

Exosomal microRNA-363 mediates the destructive effect of M1 macrophages on chondrocytes by repressing G3BP2

Experimental Cell Research
M1 polarization of synovial macrophages contributes to cartilage degeneration and osteoarthritis (OA) development. However, limited knowledge is available about how M1 macrophages affect the biological properties of chondrocytes. This study aimed to explore the role of exosomal microRNAs (miRs) released from M1 macrophages in modulating the ...
Wenteng Si, Hongchao Wei, Wenzhong Chen, Bin Chen, Yu Zhou, Huaguo Zhang   +5 more
openaire   +2 more sources

G3BP2 facilitates abnormal activation of fibroblast-like synoviocytes through p53 signaling pathway in rheumatoid arthritis

International Immunopharmacology
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis and joint destruction. While GTPase-activating protein SH3 domain-binding protein 2 (G3BP2) plays important roles in tumors and other diseases, its function in RA remains unclear.
Zhongyao Hu, Yanmin Zheng
exaly   +3 more sources

TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer

Oncogene, 2018
Prostate cancer growth is promoted by the gene regulatory action of androgen receptor (AR) and its downstream signals. The aberrant dysfunction of tumor suppressor p53 has an important role in the prognosis of cancer. We previously found that androgen treatments translocate p53 to the cytoplasm.
Ken-ichi Takayama, Takashi Suzuki, Tomoaki Tanaka, Tetsuya Fujimura, Satoru Takahashi, Tomohiko Urano, Kazuhiro Ikeda, Satoshi Inoue   +7 more
openaire   +2 more sources

Down-regulation of miR-515-5p contributes to the development of rhabdomyosarcoma through G3BP2

2019
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma found in children and young adults. By screening for potential tumor suppressive microRNAs in two RMS cell lines, we found that miR-515-5p exibited tumor suppressive functions: it is downregulated in a large fraction of RMS biopsies; its overexpression inhibited tumor growth in nude mice and
openaire   +2 more sources

Targeting of G3BP2 Refines Prognosis and Synergizes with Venetoclax in Acute Myeloid Leukemia

Blood, 2022
Zhixiang Chen, Yuanhua Cai, Xiaolin Lai, Xiaofan Li, Lili Pan, Xuechun Wang, Fuquan Tu, Luya Ye, Yang Li, Shaoyuan Wang   +9 more
openaire   +1 more source