Results 21 to 30 of about 23,913 (202)

Prevalence of G6PD deficiency and G6PD variants amongst the southern Thai population

PeerJ, 2022
BackgroundGlucose-6-phosphate dehydrogenase (G6PD) is an enzyme essential for NADPH production and protecting cells, especially red blood cells, from free radicals. The oxidative stress from drugs, chemicals, and infections can induce red blood cell hemolysis in G6PD deficiency patients, causing a genetic disorder.ObjectivesThis study aims to provide ...
Manit Nuinoon, Rungnapha Krithong, Suputcha Pramtong, Piyawit Sasuk, Chompunuch Ngeaiad, Sathanan Chaimusik, Jiraporn Kanboonma, Orawan Sarakul   +7 more
openaire   +3 more sources

Genotype-phenotype association and biochemical analyses of glucose-6-phosphate dehydrogenase variants: Implications for the hemolytic risk of using 8-aminoquinolines for radical cure

Frontiers in Pharmacology, 2022
Background:Plasmodium vivax remains the malaria species posing a major threat to human health worldwide owing to its relapse mechanism. Currently, the only drugs of choice for radical cure are the 8-aminoquinolines (primaquine and tafenoquine), which are
Sirapapha Sudsumrit, Kamonwan Chamchoy, Duantida Songdej, Poom Adisakwattana, Srivicha Krudsood, Emily R. Adams, Mallika Imwong, Ubolsree Leartsakulpanich, Usa Boonyuen   +8 more
doaj   +1 more source

G6PD Deficiency and Parkinson's Disease: An emerging correlation

Journal of Biochemical and Clinical Genetics
Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency, recognized as the most prevalent enzymopathy globally, limits pentose phosphate pathway (PPP), causing oxidative damage to dopaminergic nigrostriatal (DNS) neurons, has been implicated as a
Komal Uppal, Himani Kaushik, Sunil Kumar Polipalli, Somesh Kumar, Seema Kapoor   +4 more
doaj   +1 more source

Development and validation of a risk prediction model for hepatorenal syndrome in hepatic failure patients based on glucose-6-phosphate dehydrogenase and hepatic and renal function biochemical parameters [PDF]

Journal of Medical Biochemistry
Background: This study aimed to develop and validate a novel risk prediction model for hepatorenal syndrome (HRS) in hepatic failure (HF) patients by integrating glucose-6-phosphate dehydrogenase (G6PD) activity with conventional hepatic and renal ...
Liu Hao, Lan Yanmei, Zhang Kan, Wang Tingshuai, Mao Dewen, Wang Minggang   +5 more
doaj   +1 more source

Effect of combined G6PD deficiency and diabetes on protein oxidation and lipid peroxidation

BMC Endocrine Disorders, 2021
Background Oxidative Stress, an imbalance in the pro-oxidant/antioxidant homeostasis, occurs in many physiological and non-physiological processes and several human diseases, including diabetes mellitus (DM) and glucose-6-phosphate dehydrogenase (G6PD ...
Naif S. Karadsheh, Nisreen A. Quttaineh, Salem N. Karadsheh, Mohammad El-Khateeb   +3 more
doaj   +1 more source

Glucose-6-phosphate dehydrogenase mutations in malaria endemic area of Thailand by multiplexed high‐resolution melting curve analysis

Malaria Journal, 2021
Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzymopathy in humans, is prevalent in tropical and subtropical areas where malaria is endemic.
Usa Boonyuen, Duantida Songdej, Sasipa Tanyaratsrisakul, Suparat Phuanukoonnon, Kamonwan Chamchoy, Aun Praoparotai, Phonchanan Pakparnich, Sirapapha Sudsumrit, Thomas Edwards, Christopher T. Williams, Rachel L. Byrne, Emily R. Adams, Mallika Imwong   +12 more
doaj   +1 more source

Safety and Efficacy of Tafenoquine for Plasmodium vivax Malaria Prophylaxis and Radical Cure: Overview and Perspectives

Therapeutics and Clinical Risk Management, 2021
Miles B Markus1,2 1School of Animal, Plant and Environmental Sciences, Faculty of Science, University of the Witwatersrand, Johannesburg, South Africa; 2Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of ...
Markus MB
doaj  

The Impact of Glucose-6-Phosphate Dehydrogenase Deficiency on the Frequency of Vasoocclusive Crisis in Patients with Sickle Cell Anemia

Plasmatology, 2021
Background and Objectives Sickle cell anemia (SCA) and glucose-6-phosphate dehydrogenase (G6PD) deficiency are both hereditary diseases of the red blood cells that cause hemolysis.
Hilary Nnamezie Igwilo, Lateef Salawu, Tewogbade Adeoye Adedeji   +2 more
doaj   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

RUSH for G6PD! [PDF]

Blood, 2016
![Figure][1] A 21-year-old African American man with HIV infection, well controlled with emtricitabine, rilpivirine, and tenofovir, presented with new onset of jaundice. The night before presenting, he took the sexual enhancement drug called “RUSH.” Initial investigations revealed ...
Uqba Khan, Tarik Hadid
openaire   +2 more sources