Results 241 to 250 of about 1,961,458 (292)

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Humanized extracellular vesicles for efficient RNA delivery. [PDF]

Proc Natl Acad Sci U S A
Ma X, Zhao SR, Cepko CL.
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Dual targeting of topoisomerase I and DNA G-quadruplexes enhances senescence and chemosensitivity in colorectal cancer. [PDF]

Commun Biol
Li Y, Ji D, Jia Y, Liang Y, Wei E, Gao C, Li Y, Zeng C, Wang L, Wang C, Guo Z, Zhang Y, Zhou MM, Wu D, Zeng L.   +14 more
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Effects of graviola oil extract on fattening performance and circadian rhythms of adipokine, cardiac and mitochondrial function markers in lambs. [PDF]

BMC Vet Res
Kotan GC, Bayraktar B.
europepmc   +1 more source

FOXM1-Specific TCR-Engineered T Cells Target Non-Small Cell Lung Cancer. [PDF]

Cancer Immunol Res
Bontekoe E, Zhang M, Jiang P, Montoya A, Shulga Y, Slone JK, Paul E, Polera C, Forward S, Nassif Rausseo B, Assita ER, Xing C, Molkentine DP, Morris BB, Polic I, Roszik J, Salgado R, Vaishnavi A, Deniger D, Tran HT, Gibbons DL, Vaporciyan A, Gillison ML, Wistuba II, Kavraki LE, Zhang J, Lizee G, Yee C, Hwu P, Kwok S, Jaeger AM, Heymach JV, Reuben A.   +32 more
europepmc   +1 more source

Australian key stakeholder views regarding implementation of atrial fibrillation screening: a qualitative evaluation. [PDF]

BMJ Open
Mckenzie K, Freedman B, Jacob A, Modi RN, Lowres N.   +4 more
europepmc   +1 more source

Engineering high-fidelity tapasin variants to enhance MHC-I antigen presentation. [PDF]

J Biol Chem
Erdman MC, Epstein K, Hwang D, Khan RMM, Sun SM, Sgourakis NG.   +5 more
europepmc   +1 more source

Development of canine parvovirus-neutralizing monoclonal antibodies from natural host and their germline gene usage. [PDF]

Appl Microbiol Biotechnol
Liu G, Fu P, Zhang X, Kong F, Peng J, Kang D, Pei Y, Li K, Lu Z.   +8 more
europepmc   +1 more source