Results 41 to 50 of about 1,611,721 (265)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Teacher Self-Efficacy within the Context of Socially Disadvantaged Pupils’ Education [PDF]

Sociální Pedagogika, 2016
The teachers’ self-efficacy (TS) is one of the important determinants, which affects teachers’ behavior and also affects the effectivity of educational process.
Anna Petr Šafránková, Karla Hrbáčková   +1 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The local environmental factors impact the infestation of bee colonies by mite Varroa destructor

Ecological Indicators, 2022
Colony collapse disorder has become a global problem for beekeepers, and agriculture, which depends on bee pollination. Among other factors, the impact of the parasitic mite V. destructor, which causes varroosis, increases the risk of bee colony collapse.
Michaela Korená Hillayová, Ľubomír Korený, Jaroslav Škvarenina   +2 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Self-efficacy of Professional Educators in Institutional Care for Children and Minors [PDF]

Sociální Pedagogika, 2015
The aim of the study is to present the results of research that determine the extent to which professional educators working in educational care centres and children’s homes influence the behaviour of children in institutional care related to their ...
Karla Hrbáčková, Anna Petr Šafránková   +1 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Holographic Interferometry for Measuring the Effect of Thermal Modification on Wood Thermal Properties

Applied Sciences, 2021
The paper focuses on the use of holographic interferometry in the research of thermal modification and its effect on the heat transfer from the wood surface to the surrounding air. In the experiment, spruce wood samples modified at 160 °C, 180 °C, 200 °C,
Áron Hortobágyi, Elena Pivarčiová, Pavol Koleda   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Effect of Primary Spruce Lamella Aging on the Bending Characteristics of Glulam Beams

Applied Sciences, 2022
Glued laminated (glulam) beams are used in the roofs, ceilings and walls of buildings as well as in bridges and towers. At present, with the limitation of tree harvesting, the production of glulam beams from recycled wood sources is implemented with the ...
Ladislav Reinprecht, Dávid Ciglian, Ján Iždinský, Ján Sedliačik   +3 more
doaj   +1 more source