Results 41 to 50 of about 1,961,458 (292)

HLA-G molecules and clinical outcome in Chronic Myeloid Leukemia [PDF]

, 2017
The human leukocyte antigen-G (HLA-G) gene encodes a tolerogenic protein known to promote tumor immune-escape. We investigated HLA-G polymorphisms and soluble molecules (sHLA-G) in 68 chronic myeloid leukemia (CML) patients. Patients with G*01:01:01 or G*
Galimberti, Sara, La Nasa, G., Arras, M, Carlo Carcassi, Carcassi, C, Giovanni Caocci, Arras, Marcella, Roberto Littera, Sandro Orrù, Abruzzese, Elisabetta, Orru, S, Greco, M, Elisabetta Abruzzese, Giorgio La Nasa, Mulas, O, Martino, B, Mulas, Olga, Trucas, M, Lai, Sara, Bruno Martino, Trucas, Marcello, Martino, Bruno, Cusano, R, Lai, S, Sara Lai, Cusano, Roberto, Olga Mulas, Littera, R, Roberto Cusano, Marianna Greco, Marcello Trucas, Greco, Marianna, Orrã1, Sandro, Sara Galimberti, LA NASA, GIORGIO, Littera, Roberto, ORRU, SANDRO, Marcella Arras, CAOCCI, GIOVANNI, Abruzzese, E, Galimberti, S, CARCASSI, CARLO, Caocci, G   +42 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Effect of Transition to Close-to-Nature Forestry on Growing Stock, Wood Increment and Harvest Possibilities of Forests in Slovakia

Land
The aim of the study is to quantify the impacts of a possible transition to close-to-nature forestry in Slovakia and to compare the expected development of the total volume production, growing stock, merchantable wood increment and harvesting ...
Martina Štěrbová, Ivan Barka, Ladislav Kulla, Joerg Roessiger   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Teacher Self-Efficacy within the Context of Socially Disadvantaged Pupils’ Education [PDF]

Sociální Pedagogika, 2016
The teachers’ self-efficacy (TS) is one of the important determinants, which affects teachers’ behavior and also affects the effectivity of educational process.
Anna Petr Šafránková, Karla Hrbáčková   +1 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The local environmental factors impact the infestation of bee colonies by mite Varroa destructor

Ecological Indicators, 2022
Colony collapse disorder has become a global problem for beekeepers, and agriculture, which depends on bee pollination. Among other factors, the impact of the parasitic mite V. destructor, which causes varroosis, increases the risk of bee colony collapse.
Michaela Korená Hillayová, Ľubomír Korený, Jaroslav Škvarenina   +2 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source