Results 141 to 150 of about 19,960,264 (249)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Warren G. Harding letter to Adolphe Danziger, February 21, 1921
, 1921 In this letter dated February 21, 1921, President-elect Warren G. Harding writes to Adolphe Danziger, a Jewish scholar, lawyer and author, to thank him for the poem he wrote honoring Harding titled "Within the Storm." This letter is part of the Warren G.
Harding, Warren G. (Warren Gamaliel), 1865-1923
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Efectos de una reforma de la indemnización por despido en Argentina [PDF]
Este trabajo busca cuantificar los efectos directos de una reforma de la indemnización por despido desde el sistema tradicional hacia cuentas individuales en Argentina.
Capello, Marcelo +2 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
“La voz de los niños en las decisiones judiciales sobre su residencia” [PDF]
Este fallo de la Corte Suprema de Justicia de la Nación caratulado “G., A. J. c/ J., M. A. s/ cuidado personal de los hijos” del 16/05/24 se trata de lleno acerca de un grupo vulnerable: los niños. La decisión a la que arriba la CSJN orbita respecto a la
Aguilar Carileo, Rocio Ayelen
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Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
“Interés superior del niño: Su preponderancia en un caso migratorio bajo la mirada de la Corte” [PDF]
Etimológicamente, “vulnerabilidad” nos lleva a vulnus, en latín “herida”, como la sensibilidad o susceptibilidad de resultar herido. Es propia de la naturaleza misma del ser humano.
Mercado, Luis Gaston
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Effects of Orthotic Interventions on Pain, Balance, and Plantar Pressure in Flexible Flatfoot: A Systematic Review. [PDF]
J Foot Ankle ResChoi T, Lee S, Choi W, Heo S.
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source