Results 151 to 160 of about 19,960,264 (249)

Instructivo para la carga de proyectos de investigación [PDF]

open access: yes
Fil:Universidad Siglo 21. Vicerrectorado de Innovación, Investigación y Posgrado.
Secretaría de Investigación
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Inteligencia Emocional + Inteligencia Artificial: superando la dicotomía. Estrategias y Acuerdos para un Nuevo Contrato Didáctico 5.0 [PDF]

open access: yes
En la Industria 4.0 la tecnología está más orientada hacia la cibernética que hacia las personas (Mourtzis, D., et al, 2022). La preocupación global ante esta realidad induce a orquestar incipientes iniciativas centradas en el ser humano tendientes a la ...
Gonzalez, María Paula   +3 more
core  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Calidad democrática de las provincias argentinas [PDF]

open access: yes
El presente informe analiza la calidad democrática de las provincias argentinas a partir de una encuesta a expertos realizada entre marzo y junio de 2025.El estudio constituye uno de los pocos intentos sistemáticos por medir de manera comparada, el ...
Altavilla, Cristian
core  

Correction: Renal coccidiosis in black skimmers in North America reveals an uncharacterized Eimeria lineage (Apicomplexa: Eimeriidae). [PDF]

open access: yesPLoS One
Groch KR   +8 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

El interés superior del niño como mandato judicial en contextos de alta vulnerabilidad. [PDF]

open access: yes
El desarrollo del presente se centra en el fallo dictado por la Cámara de Apelaciones de Concordia, Sala II Civil y Comercial, en la causa “G., M. P. s/ medida de protección excepcional” (Expte.
Sierak, Sergio Javier
core  

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