Results 31 to 40 of about 5,197 (158)

Drugs in early clinical development for the treatment of osteosarcoma [PDF]

, 2015
Introduction: Osteosarcomas are the main malignant primary bone tumours found in children and young adults. Conventional treatment is based on diagnosis and resection surgery, combined with polychemotherapy.
Allen B, Bielack S, Dominique Heymann, Endo-Munoz L, Gobin B, Hannah K. Brown, Heiner JP, Henriksen G, Huvos A, Inwards C, Jentzsch T, Kalil RK, Kurzman ID, Lazar A, Liu B, Marie-Françoise Heymann, Marina N, Mifamurtide, Montag AG, Mortensen DS, Ohba T, Oliveira AM, Perrot P, Scotlandi K, Serra M, Tsukahara T, Wittrant Y, Wold LE, Yoshiyama A   +28 more
core   +3 more sources

Locations and Reorientations of Multi-Ring-Fused 2-Pyridones in Ganglioside G_M1 Micelles

Langmuir, 2011
Fluorescent multi-ring-fused 2-pyridones, with chemical resemblance to other biologically active 2-pyridone systems, were solubilized in spherical micelles formed by the ganglioside G(M1) and studied with respect to their spatial localization and rotational mobility.
Sachl, Radek, Rosenbaum, Erik, Sellstedt, Magnus, Almqvist, Fredrik, Johansson, Lennart B-Å   +4 more
openaire   +4 more sources

Concentrations of Ganglioside Type M1 and Immunoglobulin G in Colostrum Are Inversely Related to Bacterial Infection at Early Lactation in Cows [PDF]

Journal of Dairy Science, 2008
The levels of IgG and ganglioside type M1 in the colostrum of cows and heifers were analyzed to examine their utility in predicting acquisition of intramammary infection (IMI) during the first weeks postpartum. In general, high levels of IgG and ganglioside type M1 in cows were associated with lower new incidence of IMI, and linear discriminate ...
G, Leitner, O, Krifucks, S, Jacoby, Y, Lavi, N, Silanikove   +4 more
openaire   +2 more sources

Sarcoma immunotherapy. [PDF]

, 2011
Much of our knowledge regarding cancer immunotherapy has been derived from sarcoma models. However, translation of preclinical findings to bedside success has been limited in this disease, though several intriguing clinical studies hint at the potential ...
Gouw, Launce G, Jones, Kevin B, Randall, R Lor, Sharma, Sunil   +3 more
core   +2 more sources

Cancer immunology and canine malignant melanoma: a comparative review [PDF]

, 2016
Oral canine malignant melanoma (CMM) is a spontaneously occurring aggressive tumour with relatively few medical treatment options, which provides a suitable model for the disease in humans.
Atherton, Matthew J., Lichty, Brian D., McDermott, Mark R., Morris, Joanna S.   +3 more
core   +1 more source

Synthesis of a Fluorescent Ganglioside G_M1 Derivative and Screening of a Synthetic Peptide Library for G_M1 Binding Sequence Motifs [PDF]

Bioconjugate Chemistry, 2007
A ganglioside GM1 probe bearing a dark-red fluorescent dye at the sphingosine moiety of the molecule was prepared by a convenient one-pot synthesis. The labeled GM1 permitted the detection of the natural ganglioside GM1 ligand Escherichia coli heat-labile enterotoxin subunit B (EtxB) in picomole quantities on a solid support. When an epitope mapping of
Rockendorf, Niels, Bade, Steffen, Hirst, Timothy, Gorris, Hans H., Frey, Andreas   +4 more
openaire   +3 more sources

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Neurological Disorders in Primary Sjögren's Syndrome. [PDF]

, 2012
International audienceSjögren's syndrome is an autoimmune disease characterized by an autoimmune exocrinopathy involving mainly salivary and lacrimal glands.
Devauchelle-Pensec, Valérie, Pers, Jacques-Olivier, Tobón, Gabriel J, Youinou, Pierre   +3 more
core   +5 more sources

Synthesis of tri- and tetrasaccharide haptens related to the Asialo forms of the gangliosides G_M2 and G_M1 [PDF]

Canadian Journal of Chemistry, 1984
Synthesis of βDGalNAc(1→4)βDGal(1→4)βDGlc—O(CH2)8COOCH3 (21) and βDGal(1→3)βDGalNAc(1→4)βDGal(1→4)βDGlc—O(CH2)8COOCH3 (33) are presented starting from βDGal(1→4)βDGlc—O(CH2)8COOCH3 (1) and D-galactose. Improvements in the preparations of D-galactal triacetate (7) and tri-O-acetyl-2-azido-2-deoxy-α-D-galactopyranosyl bromide (11) are reported.
Subramaniam Sabesan, Raymond U. Lemieux
openaire   +1 more source

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment for Solid Tumors

Small Science, EarlyView.
This review highlights recent advances in nanomedicine that enhance chimeric antigen receptor (CAR) T cell therapy against solid tumors. It discusses key barriers to CAR T cell efficacy and outlines nanotechnology‐based strategies to improve tumor targeting, remodel the immunosuppressive microenvironment, and integrate nanomaterials into CAR T cell ...
Stephen O’Rourke, Nuo Xu, Hongjun Wang, Hexin Chen   +3 more
wiley   +1 more source