Results 211 to 220 of about 94,252 (292)

Endocrine therapy resistance of breast cancer: Important role of G protein-coupled estrogen receptor (GPER) and new therapeutic strategies. [PDF]

Genes Dis
Yu T, He C, Zhang H, Zhu Y, Wang A, Zeng X, Huang Y, Zhong J, Wu X, Shu Y, Shen G, Yu C, Zhou K, Zeb U, Dejenie R, Peng Y, Haydon RC, Luu HH, Reid RR, He TC, Fan J, Li J.   +21 more
europepmc   +1 more source

The importance of gene polymorphism in familial inheritance of endometriosis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective The study aimed to investigate familial transmission patterns in women with endometriosis by generating a customized single‐nucleotide polymorphism (SNP) array. Methods Patients aged 18–45 who were diagnosed histopathologically with endometriosis were included in the study.
Hale Goksever Celik, Candan Eker, Berivan Guzelbag, Ercan Bastu, Tuba Gunel   +4 more
wiley   +1 more source

G-protein-coupled estrogen receptor-1 facilitates chondrocyte proliferation in pubertal epiphyseal growth plate via PTHrP/Ihh regulation. [PDF]

Bone Joint Res
Chou YS, Lin SY, Chuang SC, Shih PY, Chen CH, Ho ML, Chang JK.   +6 more
europepmc   +1 more source

Beyond “you are what you eat”: Unlocking gut microbiota‐mediated biotransformation of dietary phytochemicals

iMetaOmics, EarlyView.
The “efficacy paradox” of phytochemicals, low bioavailability yet significant health benefits, is associated with gut microbiota, which biotransforms dietary precursors into bioactive metabolites, enabling systemic effects. Thus, health outcomes of diet depend not just on intake “the rainbow”, but on gut microbial metabolism, redefining “you are what ...
Peng Yang, Ren‐You Gan
wiley   +1 more source

G-Protein-coupled Estrogen Receptor 1 (GPER1) Overexpression Affects Aggressiveness of Cervical Carcinoma Cells Depending on Histological Entity. [PDF]

Cancer Genomics Proteomics
Hambach L, Gallwas J, Gründker C.
europepmc   +1 more source

Sleep deprivation aggravates hepatocytes steatosis and insulin resistance by regulating exosomal microRNAs

Interdisciplinary Medicine, EarlyView.
Sleep deprivation accelerates the progression of MASLD and IR by up‐regulating the expression of miR‐3572‐5p and down‐regulating the expression of miR‐183‐5p in circulating exosomes, thereby inhibiting fatty acid β‐oxidation and disrupting insulin signaling pathways. Abstract Sleep deprivation (SD) threatens human health and increases the prevalence of 
Xinxin Xu, Lulu Li, Ying Cao, Ying Wang, Chao Yang, Alexander Nikolaevich Orekhov, Yuanfeng Lu, Houbin Chu, Chuanrong Zhao, Guixue Wang, Guohua Song   +10 more
wiley   +1 more source

Artificial cell: An emerging bioactive material with advanced applications in cancer theranostics

Interdisciplinary Medicine, EarlyView.
Artificial cells are emerging as attractive biomimetic bioactive materials that recapitulate key structures and functions of natural cells. This review systematically summarizes their major types, versatile fabrication strategies, tuneable properties and programmable biomimetic behaviours, highlights their cutting‐edge integrated applications in cancer
Daikun Wu, Shuo Yang, Hongjing Dou
wiley   +1 more source

An Endocrine-Disrupting Chemical, Bisphenol A Diglycidyl Ether (BADGE), Accelerates Neuritogenesis and Outgrowth of Cortical Neurons via the G-Protein-Coupled Estrogen Receptor. [PDF]

NeuroSci
Miyazaki I, Nishiyama C, Nagoshi T, Miyako A, Ono S, Misawa I, Isse A, Tomimoto K, Masai K, Zensho K, Asanuma M.   +10 more
europepmc   +1 more source

Melanoma Cells Exposed to Clomiphene Citrate Respond With Cell Cycle Arrest and Reduced Invasiveness

Journal of Applied Toxicology, EarlyView.
ABSTRACT Epidemiological studies have suggested that clomiphene citrate (CC) exposure may increase the risk of malignant melanoma, but mechanisms are unknown. We investigated the effects of CC on melanoma cell line A375. Cells were treated with CC at 2, 20, 200, and 2000 ng/mL, followed by assessment of cell viability and metabolism, cell cycle ...
Thaís S. Ribeiro, Felipe H. S. Silva, Ana Paula G. S. Miranda, Isabella T. Borges, Pedro H. D. M. Prazeres, Marcia C. F. Ferreira, Enio Ferreira, Fernando M. Reis, Helen L. Del Puerto   +8 more
wiley   +1 more source

The activation of the G-protein-coupled estrogen receptor promotes the aggressiveness of MDA-MB231 cells by targeting the IRE1α/TXNIP pathway. [PDF]

Res Pharm Sci
Mohammad-Sadeghipour M, Nematollahi MH, Ahmadinia H, Hajizadeh MR, Mahmoodi M.   +4 more
europepmc   +1 more source