GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment [PDF]
Breast Cancer Research, 2017 Background The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key components of microenvironment driving tumor progression.
Ernestina M. De Francesco +5 more
doaj +5 more sources
GPER in metabolic homeostasis and disease: molecular mechanisms, nutritional regulation, and therapeutic potential [PDF]
Journal of Translational MedicineG protein-coupled estrogen receptor (GPER) significantly influences metabolic regulation by engaging multiple signaling pathways that affect overall metabolic health. Its structure and signaling mechanisms drive its diverse roles.
Liyan Liu +21 more
doaj +2 more sources
Heliyon, 2021 Estrogen is a female sex steroid hormone that plays a significant role in physiological functions. Evidence suggests that estrogen-signaling pathways are closely linked to cancer development and progression. The novel G protein-coupled estrogen receptor (
Zulvikar Syambani Ulhaq +2 more
exaly +3 more sources
G-protein-coupled estrogen receptor-1 facilitates chondrocyte proliferation in pubertal epiphyseal growth plate via PTHrP/Ihh regulation [PDF]
Bone & Joint ResearchAims: Oestrogen drives long-bone development through various oestrogen receptors. G-protein-coupled oestrogen receptor-1 (GPER-1), a membrane oestrogen receptor, mediates longitudinal bone growth during early puberty; however, the underlying mechanisms ...
Ya-Shuan Chou +6 more
doaj +2 more sources
Regulatory mechanisms of the Hippo/YAP axis by G-protein coupled estrogen receptor in gastric signet-ring cell carcinoma [PDF]
Neoplasia: An International Journal for Oncology ResearchAlthough aberrant activation of the Hippo/YAP axis has been implicated in the development of gastric cancer, functional studies of this cascade in the context of gastric signet-ring cell carcinoma (GSRC) remain absent. Our previous single-cell sequencing
Yufei Wang +14 more
doaj +2 more sources
Reduced Vitellogenesis and Female Fertility in Gper Knockout Zebrafish
Frontiers in Endocrinology, 2021 The role G-protein coupled estrogen receptor (GPER) plays in vertebrate reproduction remains controversial. To investigate GPER’s reproductive role, we generated a gper zebrafish mutant line (gper−/−) using TALENs.
Xin-Jun Wu +5 more
doaj +1 more source
G protein-coupled estrogen receptor regulates embryonic heart rate in zebrafish. [PDF]
PLoS Genetics, 2017 Estrogens act by binding to estrogen receptors alpha and beta (ERα, ERβ), ligand-dependent transcription factors that play crucial roles in sex differentiation, tumor growth and cardiovascular physiology.
Shannon N Romano +5 more
doaj +1 more source
Pharmacology Research & Perspectives, 2022 Aldosterone exerts some of its effects not by binding to mineralocorticoid receptors, but rather by acting via G protein‐coupled estrogen receptors (GPER).
Qingming Ding +5 more
doaj +1 more source
GPER-induced signaling is essential for the survival of breast cancer stem cells. [PDF]
, 2020 G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells.
Chan, Yu-Tzu +12 more
core +2 more sources
The G-protein coupled estrogen receptor (GPER/GPR30) is a gonadotropin receptor dependent positive prognosticator in ovarian carcinoma patients. [PDF]
PLoS ONE, 2013 Follicle stimulating hormone receptor (FSHR) and luteinizing hormone receptor (LHCGR) were demonstrated to impact upon survival of patients suffering from epithelial ovarian cancer (EOC).
Sabine Heublein +6 more
doaj +1 more source