Results 1 to 10 of about 4,592 (135)

Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist

Pharmacology Research and Perspectives, 2022
Aldosterone exerts some of its effects not by binding to mineralocorticoid receptors, but rather by acting via G protein‐coupled estrogen receptors (GPER).
Ross Feldman
exaly   +2 more sources

Association between GPER gene polymorphisms and GPER expression levels with cancer predisposition and progression

Heliyon, 2021
Estrogen is a female sex steroid hormone that plays a significant role in physiological functions. Evidence suggests that estrogen-signaling pathways are closely linked to cancer development and progression. The novel G protein-coupled estrogen receptor (
Gita Vita Soraya, Zulvikar Syambani Ulhaq, Ka Fai William Tse   +2 more
exaly   +3 more sources

GPER in metabolic homeostasis and disease: molecular mechanisms, nutritional regulation, and therapeutic potential [PDF]

Journal of Translational Medicine
G protein-coupled estrogen receptor (GPER) significantly influences metabolic regulation by engaging multiple signaling pathways that affect overall metabolic health. Its structure and signaling mechanisms drive its diverse roles.
Liyan Liu, Yutao Zhou, Jing Liu, Xinmiao Zhang, Chongwu He, Xiaoqiang Zeng, Rebeka Dejenie, Usman Zeb, Qiao Zeng, Lan Liu, Jianglong Li, Xingsheng Zeng, Qinglong Hu, Xianming Huang, Xue Xu, Hanzhi Dong, Jinxiu Zhong, Yanxiao Huang, Qiaoli Lv, Bo Liu, Yu-an Qiu, Tenghua Yu   +21 more
doaj   +2 more sources

Reduced Vitellogenesis and Female Fertility in Gper Knockout Zebrafish

Frontiers in Endocrinology, 2021
The role G-protein coupled estrogen receptor (GPER) plays in vertebrate reproduction remains controversial. To investigate GPER’s reproductive role, we generated a gper zebrafish mutant line (gper−/−) using TALENs.
Xin-Jun Wu, Marcus Jermaul Williams, Kimberly Ann Kew, Aubrey Converse, Peter Thomas, Yong Zhu   +5 more
doaj   +1 more source

G protein-coupled estrogen receptor regulates embryonic heart rate in zebrafish. [PDF]

PLoS Genetics, 2017
Estrogens act by binding to estrogen receptors alpha and beta (ERα, ERβ), ligand-dependent transcription factors that play crucial roles in sex differentiation, tumor growth and cardiovascular physiology.
Shannon N Romano, Hailey E Edwards, Jaclyn Paige Souder, Kevin J Ryan, Xiangqin Cui, Daniel A Gorelick   +5 more
doaj   +1 more source

Decreased Levels of G Protein-Coupled Estrogen Receptor in Bipolar Patients

Genel Tıp Dergisi, 2023
Objectives: There is increasing evidence in the literature that estrogen and its receptors play an important role in the etiopathogenesis of bipolar disorder due to gender differences in the course, severity and peak periods of the disease.
Nurinnisa Öztürk, Onur Hurşitoğlu, Ömer Faruk Uygur, Ergul Belge Kurutas   +3 more
doaj   +1 more source

The G-protein coupled estrogen receptor (GPER/GPR30) is a gonadotropin receptor dependent positive prognosticator in ovarian carcinoma patients. [PDF]

PLoS ONE, 2013
Follicle stimulating hormone receptor (FSHR) and luteinizing hormone receptor (LHCGR) were demonstrated to impact upon survival of patients suffering from epithelial ovarian cancer (EOC).
Sabine Heublein, Doris Mayr, Thomas Vrekoussis, Klaus Friese, Simone S Hofmann, Udo Jeschke, Miriam Lenhard   +6 more
doaj   +1 more source

Evidence for G‐Protein–Coupled Estrogen Receptor as a Pronatriuretic Factor

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background The novel estrogen receptor, G‐protein–coupled estrogen receptor (GPER), is responsible for rapid estrogen signaling. GPER activation elicits cardiovascular and nephroprotective effects against salt‐induced complications, yet there is no ...
Eman Y. Gohar, Elizabeth M. Daugherty, Jeffrey O. Aceves, Randee Sedaka, Ijeoma E. Obi, J. Miller Allan, Reham H. Soliman, Chunhua Jin, Carmen De Miguel, Sarah H. Lindsey, Jennifer S. Pollock, David M. Pollock   +11 more
doaj   +1 more source

High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and predicts poor patient outcomes

npj Breast Cancer, 2022
Triple-negative breast cancer (TNBC) is a particularly aggressive and heterogeneous disease with few effective targeted therapies and precision therapeutic options over a long period. It is generally considered that TNBC is an estrogen-independent breast
Ting Xu, Ding Ma, Sheng Chen, Rui Tang, Jianling Yang, Chunhui Meng, Yang Feng, Li Liu, Jiangfen Wang, Haojun Luo, Keda Yu   +10 more
doaj   +1 more source

A convex formulation for voltage unbalance compensation problem on hybrid microgrids

Revista Principia, 2019
Voltage unbalance is a power quality condition that arises due to the presence of unbalanced single-phase loads. The presence of voltage unbalances affects negatively a series of sensible equipment and, therefore, is undesirable.
José Diogo Forte de Oliveira Luna, Paulo Renato da Costa Mendes, Julio Elias Normey-Rico   +2 more
doaj   +1 more source