Results 31 to 40 of about 10,884 (213)

Neonicotinoid insecticides promote breast cancer progression via G protein-coupled estrogen receptor: In vivo, in vitro and in silico studies

Environment International, 2022
Neonicotinoid insecticides (NIs) have been widely detected in environmental media and human body with concentrations reaching hundreds of nanomolar to micromolar levels.
Xin Li, Sen He, Han Xiao, Ting-Ting He, Jia-Da Zhang, Zi-Rui Luo, Jie-Zhi Ma, Yu-Long Yin, Lin Luo, Lin-Ying Cao   +9 more
doaj   +1 more source

GPER-1 in chronic hepatitis B [PDF]

Journal of Radiation Research and Applied Sciences, 2020
Estrogen has a significant role in regulating cell proliferation, growth, migration, aging, and many disease states.
Bahar Kandemir, Selma Ates, Ergül Belge Kurutas, Yasemin Durduran, Ibrahim Erayman, Mehmet Bitirgen   +5 more
openaire   +1 more source

Obligatory role for GPER in cardiovascular aging and disease [PDF]

Science Signaling, 2016
The G protein–coupled receptor GPER promotes hypertension and aging-induced tissue damage through reactive oxygen species.
Meyer MR, Fredette NC, Daniel C, Sharma G, Amann K, Arterburn JB, Barton M, Prossnitz ER   +7 more
openaire   +3 more sources

Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30. [PDF]

PLoS ONE, 2012
The discovery of the G protein-coupled estrogen receptor GPER (also GPR30) and the resulting development of selective chemical probes have revealed new aspects of estrogen receptor biology.
Ritwik Burai, Chinnasamy Ramesh, Tapan K Nayak, Megan K Dennis, Bj K Bryant, Eric R Prossnitz, Jeffrey B Arterburn   +6 more
doaj   +1 more source

High-Frequency network activity, global increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures In Vitro [PDF]

, 2010
How seizures start is a major question in epilepsy research. Preictal EEG changes occur in both human patients and animal models, but their underlying mechanisms and relationship with seizure initiation remain unknown.
Bujan, A. F., Chang, W. C., Csicsvari, J., Dearden, R. W., Fox, J. E., Jefferys, J. G. R., Jiruska, P., Li, X., Palus, M., Powell, A. D., Vreugdenhil, Martin   +10 more
core   +2 more sources

Cryptotanshinone inhibits proliferation and induces apoptosis of breast cancer MCF-7 cells via GPER mediated PI3K/AKT signaling pathway.

PLoS ONE, 2022
G protein-coupled estrogen receptor (GPER) was reported to be a potential target in the breast cancer therapy. This study aimed to illuminate the function of GPER and its mediated PI3K/AKT pathway in cryptotanshinone (CPT) inducing cell apoptosis and ...
Danning Shi, Hongbo Li, Zeye Zhang, Yueshuang He, Meng Chen, Liping Sun, Piwen Zhao   +6 more
doaj   +2 more sources

Oestrogen receptor alpha in pulmonary hypertension [PDF]

, 2015
Aims Pulmonary arterial hypertension (PAH) occurs more frequently in women with mutations in bone morphogenetic protein receptor type 2 (BMPR2) and dysfunctional BMPR2 signalling underpinning heritable PAH.
Audrey F. Wright, Austin, Benza, Chambliss, Dempsie, Dempsie, Eddahibi, Huang, Humbert, Jala, Kawut, Keegan, Kirsty Mair, Lahm, Lindberg, Long, Long, Lynn Loughlin, Ma, Machado, MacLean, Mair, Margaret Nilsen, Margaret R. Maclean, Marie-Ann Ewart, Marino, Massaro, Massaro, Matori, Matsumoto, Mcgoon, Mendelsohn, Meyer, Meyer, Morani, Nadadur, Nilsson, Pattarozzi, Pedram, Pedram, Rajkumar, Roberts, Rubanyi, Ryu, Shapiro, Takahashi, Umar, Ventetuolo, White, White, White, Wu, Yang, Yvonne Dempsie   +53 more
core   +4 more sources

NHERF1, a novel GPER associated protein, increases stability and activation of GPER in ER-positive breast cancer [PDF]

Oncotarget, 2016
G protein-coupled estrogen receptor (GPER) plays an important role in mediating the effects of estradiol. High levels of GPER have been implicated to associate with the malignant progress of invasive breast cancer (IBC). However, the mechanisms by which GPER protein levels were regulated remain unclear.
Meng, Ran, Qin, Qiong, Xiong, Ying, Wang, Yan, Zheng, Junfang, Zhao, Yuan, Tao, Tao, Wang, Qiqi, Liu, Hua, Wang, Songlin, Jiang, Wen Guo, He, Junqi   +11 more
openaire   +3 more sources

The Peptide ERα17p Is a GPER Inverse Agonist that Exerts Antiproliferative Effects in Breast Cancer Cells

Cells, 2019
The inhibition of the G protein-coupled estrogen receptor (GPER) offers promising perspectives for the treatment of breast tumors. A peptide corresponding to part of the hinge region/AF2 domain of the human estrogen receptor α (ERα17p, residues 295–311 ...
Rosamaria Lappano, Christophe Mallet, Bruno Rizzuti, Fedora Grande, Giulia Raffaella Galli, Cillian Byrne, Isabelle Broutin, Ludivine Boudieu, Alain Eschalier, Yves Jacquot, Marcello Maggiolini   +10 more
doaj   +1 more source

Pacman Percolation and the Glass Transition [PDF]

, 2013
We investigate via Monte Carlo simulations the kinetically constrained Kob-Andersen lattice glass model showing that, contrary to current expectations, the relaxation process and the dynamical heterogeneities seems to be characterized by different time ...
Ciamarra, Massimo Pica, Coniglio, Antonio, Pastore, Raffaele   +2 more
core   +3 more sources