The G protein-coupled estrogen receptor (GPER) is expressed in two different subcellular localizations reflecting distinct tumor properties in breast cancer. [PDF]
PLoS ONE, 2014 INTRODUCTION:The G protein-coupled estrogen receptor (GPER) is a novel estrogen receptor that mediates proliferative effects induced by estrogen but also by tamoxifen.
Eleftherios P Samartzis +5 more
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On the Benefits of Inoculation, an Example in Train Scheduling [PDF]
, 2006 The local reconstruction of a railway schedule following a small perturbation of the traffic, seeking minimization of the total accumulated delay, is a very difficult and tightly constrained combinatorial problem.
Schoenauer, Marc, Semet, Yann
core +5 more sources
Molecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance
The Journal of Clinical Investigation, 2023 The rostral ventromedial medulla (RVM) exerts bidirectional descending modulation of pain attributable to the activity of electrophysiologically identified pronociceptive ON and antinociceptive OFF neurons.
Yingfu Jiao +23 more
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Journal of Ovarian Research, 2012 Background Even though ovarian tumors are not generally considered estrogen-sensitive, estrogens may still have an impact on ovarian tumor progression. The recently identified trans-membrane estrogen receptor GPER is involved in rapid estrogen signaling.
Kolkova Zuzana +6 more
doaj +1 more source
Low expression of G protein-coupled oestrogen receptor 1 (GPER) is associated with adverse survival of breast cancer patients [PDF]
, 2018 G protein-coupled oestrogen receptor 1 (GPER), also called G protein-coupled receptor 30 (GPR30), is attracting considerable attention for its potential role in breast cancer development and progression.
Adamo +32 more
core +2 more sources
Brain Research BulletinEvidence suggest that estrogens play crucial roles in the regulation of neural development and function and the G protein-coupled estrogen receptor (GPER/GPR30) appears to be the predominant estrogen receptor in the brain.
Meimei Wu +7 more
doaj +1 more source
Prognostic role of GPER/Ezrin in triple-negative breast cancer is associated with menopausal status
Endocrine Connections, 2019 The role of G protein-coupled estrogen receptor 1 (GPER) signaling, including promotion of Ezrin phosphorylation (which could be activated by estrogen), has not yet been clearly identified in triple-negative breast cancer (TNBC).
Shuang Ye +5 more
doaj +1 more source
The Role of G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology
Biomolecules, 2023 Objective: Estrogen is indispensable in health and disease and mainly functions through its receptors. The protection of the cardiovascular system by estrogen and its receptors has been recognized for decades.
Fujie Xu +7 more
doaj +1 more source
DNA methylation in the upstream CpG island of the GPER locus and its relationship with GPER expression in colon cancer cell lines [PDF]
Molecular Biology Reports, 2020 Abstract The seven-transmembrane G-protein coupled estrogen receptor (GPER) relays short-term non-genomic responses in target cells and tissues. It is a proposed tumor suppressor, which frequently undergoes down-modulation in primary tumors of the breast, ovary, and endometrium.
Uttariya Pal +2 more
openaire +2 more sources
Function of G-Protein-Coupled Estrogen Receptor-1 in Reproductive System Tumors
Journal of Immunology Research, 2016 The G-protein-coupled estrogen receptor-1 (GPER-1), also known as GPR30, is a novel estrogen receptor mediating estrogen receptor signaling in multiple cell types.
Hongyan Qian +3 more
doaj +1 more source