G-Protein-Coupled Estrogen Receptor (GPER) in Inflammatory Myopathies [PDF]
Neurology InternationalBackground/Objectives: Given the multifaceted role of estrogen hormones in skeletal muscle pathophysiology and their well-established immunomodulatory properties, this study aimed to characterize the expression of the G-protein-coupled estrogen receptor (
Delia Righi +9 more
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G protein–coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension [PDF]
Frontiers in Endocrinology, 2023 Aldosterone is one of the most essential hormones synthesized by the adrenal gland because it regulates water and electrolyte balance. G protein–coupled estrogen receptor (GPER) is a newly discovered aldosterone receptor, which is proposed to mediate the
Xuehan Li +11 more
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Frontiers in Endocrinology, 2020 The regulatory role of estrogens and nuclear estrogen receptors, i. e., estrogen receptor α and β has been reported in gastrointestinal diseases. However, the contribution of G protein-coupled estrogen receptor, the membrane-bound estrogen receptor, is ...
Damian Jacenik, Wanda M. Krajewska
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The G Protein-Coupled Estrogen Receptor (GPER): A Critical Therapeutic Target for Cancer [PDF]
Cells, 2023 Estrogens have been implicated in the pathogenesis of various cancers, with increasing concern regarding the overall rising incidence of disease and exposure to environmental estrogens. Estrogens, both endogenous and environmental, manifest their actions
Keith A. Hall, Edward J. Filardo
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G protein-coupled estrogen receptor expression in postnatal developing mouse retina [PDF]
Frontiers in OphthalmologyIntroductionEstrogen has emerged as a multifaceted signaling molecule in the retina, playing an important role in neural development and providing neuroprotection in adults.
Wendy L. Piñon-Teal +2 more
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Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia [PDF]
Experimental Hematology & Oncology, 2022 Activating G protein-coupled estrogen receptor 1 (GPER1) is an attractive therapeutic strategy for treating a variety of human diseases including cancer.
Eugenio Morelli +22 more
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G Protein-Coupled Estrogen Receptor: A Potential Therapeutic Target in Cancer
Frontiers in Endocrinology, 2019 The G protein-coupled estrogen receptor (GPER) is a seven-transmembrane-domain receptor that mediates non-genomic estrogen related signaling. After ligand activation, GPER triggers multiple downstream pathways that exert diverse biological effects on the
Shen Xu +5 more
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The Role of G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology [PDF]
Biomolecules, 2023 Objective: Estrogen is indispensable in health and disease and mainly functions through its receptors. The protection of the cardiovascular system by estrogen and its receptors has been recognized for decades.
Fujie Xu +7 more
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G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults [PDF]
Communications BiologyAccumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically intracellular, and it is unknown how these two proteinopathies are connected.
Shahram Oveisgharan +10 more
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β-arrestin regulates estradiol membrane-initiated signaling in hypothalamic neurons. [PDF]
, 2015 Estradiol (E2) action in the nervous system is the result of both direct nuclear and membrane-initiated signaling (EMS). E2 regulates membrane estrogen receptor-α (ERα) levels through opposing mechanisms of EMS-mediated trafficking and internalization ...
Abrams, Matthew C +2 more
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