G-Protein-Coupled Estrogen Receptor (GPER) in Inflammatory Myopathies [PDF]
Neurology InternationalBackground/Objectives: Given the multifaceted role of estrogen hormones in skeletal muscle pathophysiology and their well-established immunomodulatory properties, this study aimed to characterize the expression of the G-protein-coupled estrogen receptor (
Delia Righi +9 more
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G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization [PDF]
Frontiers in Cell and Developmental Biology, 2020 Mechanical forces regulate cell functions through multiple pathways. G protein-coupled estrogen receptor (GPER) is a seven-transmembrane receptor that is ubiquitously expressed across tissues and mediates the acute cellular response to estrogens.
Dariusz Lachowski +7 more
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G protein–coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension [PDF]
Frontiers in Endocrinology, 2023 Aldosterone is one of the most essential hormones synthesized by the adrenal gland because it regulates water and electrolyte balance. G protein–coupled estrogen receptor (GPER) is a newly discovered aldosterone receptor, which is proposed to mediate the
Xuehan Li +11 more
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The G Protein-Coupled Estrogen Receptor (GPER): A Critical Therapeutic Target for Cancer [PDF]
Cells, 2023 Estrogens have been implicated in the pathogenesis of various cancers, with increasing concern regarding the overall rising incidence of disease and exposure to environmental estrogens. Estrogens, both endogenous and environmental, manifest their actions
Keith A. Hall, Edward J. Filardo
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G protein-coupled estrogen receptor expression in postnatal developing mouse retina [PDF]
Frontiers in OphthalmologyIntroductionEstrogen has emerged as a multifaceted signaling molecule in the retina, playing an important role in neural development and providing neuroprotection in adults.
Wendy L. Piñon-Teal +2 more
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The Role of G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology [PDF]
Biomolecules, 2023 Objective: Estrogen is indispensable in health and disease and mainly functions through its receptors. The protection of the cardiovascular system by estrogen and its receptors has been recognized for decades.
Fujie Xu +7 more
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G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults [PDF]
Communications BiologyAccumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically intracellular, and it is unknown how these two proteinopathies are connected.
Shahram Oveisgharan +10 more
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Recent advances of G protein‐coupled estrogen receptor 1 in the metabolism of bone
Kouqiang hemian waike zazhi, 2023 The G protein‐coupled estrogen receptor 1 (GPER1) is a membrane receptor for estrogen and it plays an important role in estrogen mediated bone metabolism by triggering downstream responses through rapid cellular pleiotropic effects and influencing the ...
FENG Yuan, WANG Zuolin
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Estrogen Receptor Function: Impact on the Human Endometrium
Frontiers in Endocrinology, 2022 The physiological role of estrogen in the female endometrium is well established. On the basis of responses to steroid hormones (progesterone, androgen, and estrogen), the endometrium is considered to have proliferative and secretory phases. Estrogen can
Kun Yu +5 more
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Frontiers in Endocrinology, 2020 The regulatory role of estrogens and nuclear estrogen receptors, i. e., estrogen receptor α and β has been reported in gastrointestinal diseases. However, the contribution of G protein-coupled estrogen receptor, the membrane-bound estrogen receptor, is ...
Damian Jacenik, Wanda M. Krajewska
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