Results 31 to 40 of about 94,252 (292)

Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor β [PDF]

Pharmaceutical Sciences Asia, 2022
Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and G protein-coupled ...
Emdormi Rymbai, Deepa Sugumar, Dhritiman Roy, Divakar Selvaraj   +3 more
doaj   +1 more source

Duplicated membrane estrogen receptors in the European sea bass (Dicentrarchus labrax): Phylogeny, expression and regulation throughout the reproductive cycle [PDF]

, 2018
The numerous estrogen functions reported across vertebrates have been classically explained by their binding to specific transcription factors, the nuclear estrogen receptors (ERs).
Alvarado, M. Victoria, Andrade, André, Estêvão, M. Dulce, Felip, Alicia, Pinto, Patricia IS, Power, Deborah   +5 more
core   +1 more source

Crosstalk between nuclear and G protein-coupled estrogen receptors [PDF]

General and Comparative Endocrinology, 2018
In 2005, two groups independently discovered that the G protein-coupled receptor GPR30 binds estradiol in cultured cells and, in response, initiates intracellular signaling cascades Revankar et al. (2005), Thomas et al. (2005). GPR30 is now referred to as GPER, the G-protein coupled estrogen receptor Prossnitz and Arterburn (2015).
Shannon N, Romano, Daniel A, Gorelick
openaire   +2 more sources

Peripheral and central mechanisms involved in hormonal control of male and female reproduction [PDF]

, 2016
Reproduction involves the integration of hormonal signals acting across multiple systems togenerate a synchronized physiological output. A critical component of reproduction is the luteinizinghormone (LH) surge, which is mediated by estradiol (E2) and ...
Bentley, G. E., Calandra, Ricardo Saul, Micevych, P. E., Paredes, A. H., Rudolph, L. M., Tesone, Marta, Wu, T. J.   +6 more
core   +1 more source

Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER [PDF]

BMC Cancer, 2015
Estrogen (17β-estradiol) promotes the survival and proliferation of breast cancer cells and its receptors represent important therapeutic targets. The cellular actions of estrogen are mediated by the nuclear estrogen receptors ERα and ERβ as well as the 7-transmembrane spanning G protein-coupled estrogen receptor (GPER).
Zekas, Erin, Prossnitz, Eric R.
openaire   +2 more sources

Ginsenoside Rg1 activates ligand-independent estrogenic effects via rapid estrogen receptor signaling pathway

Journal of Ginseng Research, 2019
Background: Ginsenoside Rg1 was shown to exert ligand-independent activation of estrogen receptor (ER) via mitogen-activated protein kinase–mediated pathway.
Quan-Gui Gao, Li-Ping Zhou, Vien Hoi-Yi Lee, Hoi-Yi Chan, Cornelia Wing-Yin Man, Man-Sau Wong   +5 more
doaj   +1 more source

Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS [PDF]

, 2017
Estrogens play a key role in regulating reproductive and neuroendocrine function by activating classical nuclear steroid receptors that act as ligand gated transcription factors.
Abdelhamid, Adams, Akama, Al-Sweidi, Almey, Almey, Almey, Amy Alexander, Andrew J. Irving, Ariazi, Bliss, Bologa, Bourque, Brailoiu, Brinton, Briz, Briz, Chen, Choleris, Collingridge, Daniel, Davis, Dennis, Ding, Dubal, Ervin, Evans, Filardo, Filardo, Filardo, Foy, Frick, Frick, Fukazawa, Fukuda, Funakoshi, Gabor, Geary, Gibbs, Gibbs, Gillies, Gingerich, Gould, Gros, Gruber, Hall, Hammond, Hammond, Hammond, Hawley, Hazell, Isensee, Jenni Harvey, Kang, Kastenberger, Kastenberger, Kelly, Kramár, Kretz, Kwon, Lagrange, Langer, Lebesgue, Levin, Liu, Liu, Liu, Magalhaes, Maggiolini, Man, Marin, McEwen, McEwen, Micevych, Milner, Milner, Mitterling, Moga, Mukai, Murakami, Mårtensson, Nilsson, Noel, Otto, Park, Petrie, Potier, Prossnitz, Prossnitz, Prossnitz, Qiu, Revankar, Romeo, Rudolf, Ruiz-Palmero, Ruiz-Palmero, Sanchez, Sellers, Simpkins, Simpkins, Smejkalova, Smith, Smith, Smith, Sortino, Srivastava, Srivastava, Srivastava, Srivastava, Sudo, Sun, Tada, Thomas, Thomas, Thomas, Tsai, Vasudevan, Walf, Walf, Wang, Waters, Woolley, Woolley, Zadran, Zhang, Zhang, Zhou, Zhou, Zhou   +128 more
core   +2 more sources

Expression and Role of the G Protein-Coupled Estrogen Receptor (GPR30/GPER) in the Development and Immune Response in Female Reproductive Cancers

Frontiers in Endocrinology, 2020
Cancer is a major public health issue and represents the second leading cause of death in women worldwide, as female reproductive-related neoplasms are the main cause of incidence and mortality.
Christian David Hernández-Silva, Julio César Villegas-Pineda, Julio César Villegas-Pineda, Ana Laura Pereira-Suárez, Ana Laura Pereira-Suárez   +4 more
doaj   +1 more source

Estrogen Actions in Triple-Negative Breast Cancer

Cells, 2020
Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) α, but the expression of estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to trigger estrogen-responsivity in TNBC.
Oliver Treeck, Susanne Schüler-Toprak, Olaf Ortmann   +2 more
doaj   +1 more source

Oestrogen receptor alpha in pulmonary hypertension [PDF]

, 2015
Aims Pulmonary arterial hypertension (PAH) occurs more frequently in women with mutations in bone morphogenetic protein receptor type 2 (BMPR2) and dysfunctional BMPR2 signalling underpinning heritable PAH.
Audrey F. Wright, Austin, Benza, Chambliss, Dempsie, Dempsie, Eddahibi, Huang, Humbert, Jala, Kawut, Keegan, Kirsty Mair, Lahm, Lindberg, Long, Long, Lynn Loughlin, Ma, Machado, MacLean, Mair, Margaret Nilsen, Margaret R. Maclean, Marie-Ann Ewart, Marino, Massaro, Massaro, Matori, Matsumoto, Mcgoon, Mendelsohn, Meyer, Meyer, Morani, Nadadur, Nilsson, Pattarozzi, Pedram, Pedram, Rajkumar, Roberts, Rubanyi, Ryu, Shapiro, Takahashi, Umar, Ventetuolo, White, White, White, Wu, Yang, Yvonne Dempsie   +53 more
core   +4 more sources