The Importance of G-protein Coupled Estrogen Receptor in Patients With Fibromyalgia
Archives of Rheumatology, 2019 Objectives: This study aims to analyze the G-protein coupled estrogen receptor (GPER/GPR30) activity in patients with fibromyalgia syndrome (FMS). Patients and methods: We enrolled 40 female patients with FMS (mean age 42.9±11.2 years; range, 18 to 64 years) diagnosed according to the 2010 American College of Rheumatology classification criteria and ...
Tuba, Koca +3 more
openaire +3 more sources
GPER was associated with hypertension in post-menopausal women
Open Medicine, 2018 To explore the relationship between G protein-coupled estrogen receptor (GPER) and hypertension in post-menopausal women.
Liu Shichao +3 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: Female sex is associated with lower incidence and improved clinical outcomes for most cancer types including pancreatic ductal adenocarcinoma (PDAC). The mechanistic basis for this sex difference is unknown.
Christopher A. Natale +8 more
doaj +1 more source
Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]
, 2018 Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille +12 more
core +2 more sources
Estrogen Signaling through the G Protein–Coupled Estrogen Receptor Regulates Granulocyte Activation in Fish [PDF]
The Journal of Immunology, 2013 Abstract Neutrophils are major participants in innate host responses. It is well known that estrogens have an immune-modulatory role, and some evidence exists that neutrophil physiology can be altered by these molecules. Traditionally, estrogens act via classical nuclear estrogen receptors, but the identification of a G protein–coupled ...
Cabas, I. (Isabel) +5 more
openaire +5 more sources
17,β-estradiol inhibits hepatitis C virus mainly by interference with the release phase of its life cycle [PDF]
, 2016 Rationale & Aim: Estrogen and estrogen-mediated signalling protect from hepatitis C virus through incompletely understood mechanisms. We aimed to ascertain which phase(s) of HCV life cycle is/are affected by estrogens.
Barbaglia, Matteo N. +10 more
core +2 more sources
G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health [PDF]
Journal of Menopausal Medicine, 2015 Estrogen - the female sexual hormone playing the most important role - plays a physiologically significant role, not only regulating in cell signals with second messenger but also being active in regulating transcription. Estrogen receptor (ER) which is a protein accepting estrogen not only play the role of a transcription factor combining with other ...
Kim, Mi-Jin +2 more
openaire +2 more sources
G Protein-Coupled Estrogen Receptor-Selective Ligands Modulate Endometrial Tumor Growth
Obstetrics and Gynecology International, 2013 Endometrial carcinoma is the most common cancer of the female reproductive tract. GPER/GPR30 is a 7-transmembrane spanning G protein-coupled receptor that has been identified as the third estrogen receptor, in addition to ERα and ERβ.
Whitney K. Petrie +7 more
doaj +1 more source
Therapeutic Perspectives on the Modulation of G-Protein Coupled Estrogen Receptor, GPER, Function
Frontiers in Endocrinology, 2020 Estrogens exert their physiological and pathophysiological effects via cellular receptors, named ERα, ERβ, and G-protein coupled estrogen receptor (GPER).
Milad Rouhimoghadam +6 more
doaj +1 more source
Recent advances on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangiocyte pathophysiology [PDF]
, 2013 Cholangiocytes are epithelial cells lining the biliary epithelium. Cholangiocytes play several key roles in the modification of ductal bile and are also the target cells in chronic cholestatic liver diseases (i.e., cholangiopathies) such as PSC, PBC ...
Alvaro, Domenico +6 more
core +1 more source