Results 1 to 10 of about 18,705 (150)

GPR30 predicts poor survival for ovarian cancer [PDF]

Gynecologic Oncology, 2009
GPR30 is a 7-transmembrane G protein-coupled estrogen receptor that functions alongside traditional estrogen receptors to regulate cellular responses to estrogen. Recent studies suggest that GPR30 expression is linked to lower survival rates in endometrial and breast cancer.
Tamara Howard, Clifford R Qualls, Claire F Verschraegen   +2 more
exaly   +3 more sources

GPR30: A G protein-coupled receptor for estrogen [PDF]

Molecular and Cellular Endocrinology, 2007
Estrogen is a critical steroid in human physiology exerting its effect both at the transcriptional level as well as at the level of rapid intracellular signaling through second messengers. Many of estrogen's transcriptional effects have long been known to be mediated through classical nuclear steroid receptors but recent studies also demonstrate the ...
Eric R Prossnitz
exaly   +3 more sources

The GPR30 agonist G-1 promotes hair growth via Wnt/Hedgehog signaling in mice [PDF]

Frontiers in Pharmacology
BackgroundGPR30 is a membrane-associated receptor involved in rapid, non-genomic estrogen signaling. Estrogen significantly influences hair growth and susceptibility to hair loss, with differences primarily driven by hormonal factors.
Mayu Yamano, Yuto Yamanaka, Shota Nishikawa, Yuki Masujima, Ryuji Ohue-Kitano, Ikuo Kimura, Ikuo Kimura, Ikuo Kimura   +7 more
doaj   +2 more sources

GPR30 mediates estrogen rapid signaling and neuroprotection [PDF]

Molecular and Cellular Endocrinology, 2014
G-protein-coupled estrogen receptor-30 (GPR30), also known as G-protein estrogen receptor-1 (GPER1), is a putative extranuclear estrogen receptor whose precise functions in the brain are poorly understood. Studies using exogenous administration of the GPR30 agonist, G1 suggests that GPR30 may have a neuroprotective role in cerebral ischemia.
Quanguang Zhang, Mohammad Khan, Darrell W Brann   +2 more
exaly   +3 more sources

The ins and outs of GPR30: A transmembrane estrogen receptor [PDF]

Journal of Steroid Biochemistry and Molecular Biology, 2008
Estrogen is an important hormone in human physiology. It acts both via transcriptional regulation as well as via modulation of intracellular signaling through second messengers. Although estrogen's transcriptional effects occur through classical nuclear steroid receptors (ERs), recent studies reveal the existence of a novel 7-transmembrane G protein ...
Eric R Prossnitz, Tudor I Oprea
exaly   +3 more sources

GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain [PDF]

eLife
Neuropathic pain, a major health problem affecting 7–10% of the global population, lacks effective treatment due to its elusive mechanisms. Cholecystokinin-positive (CCK+) neurons in the spinal dorsal horn (SDH) are critical for neuropathic pain, yet the
Qing Chen, Hui Wu, Shulan Xie, Fangfang Zhu, Fang Xu, Qi Xu, Lihong Sun, Yue Yang, Linghua Xie, Jiaqian Xie, Hua Li, Ange Dai, Wenxin Zhang, Luyang Wang, Cuicui Jiao, HongHai Zhang, Xuelong Zhou, Zhen-Zhong Xu, Xinzhong Chen   +18 more
doaj   +2 more sources

Potential Roles of G Protein-Coupled Receptor 30 (GPR30) in Migraine Pathophysiology [PDF]

Journal of Pain Research
Yuning Yao,1 Yang Gong,1,* Kegang Cao2,* 1Department of Traditional Chinese Medicine, General Hospital of the PLA Northern Theater Command, Shenyang, Liaoning, People’s Republic of China; 2Department of Neurology, Dongzhimen Hospital of ...
Yao Y, Gong Y, Cao K
doaj   +2 more sources

Tranexamic acid protects human dermal fibroblasts from D-galactose-induced senescence via the GPR30/MAPK pathway [PDF]

Annals of Medicine
Background Tranexamic acid (TXA) is widely used for pigmentary disorders, but its anti-ageing potential remains unclear. This study aimed to evaluate whether topical 3% TXA improves early periorbital wrinkles in women with facial melasma and to ...
Yanyan Lin, Yaling Wang, Wanjing Wang, Zhili Deng, Yiya Zhang, Yiran Peng, Jin Tang, Ji Li, Chuchu Huang, Dan Jian   +9 more
doaj   +2 more sources

The Correlation between GPR30 and Clinicopathologic Variables in Breast Carcinomas [PDF]

Technology in Cancer Research and Treatment, 2009
The G-protein-coupled-receptor 30 (GPR30) is a new membrane estrogen receptor. The aim of the present study was to determine the correlations among GPR30, ERα, PR, C-erbB-2, p53, TNM stage, and pathologic grade in breast carcinomas. Two hundred forty-one biopsy specimens were evaluated with immunohistochemical assays, and then correlations were ...
Gang Tu, Guanglun Yang, Tinghe Yu
exaly   +3 more sources

Effects of Zearalenone on the Kiss1/GPR54 System and Related Genes Expression in the Hypothalamus and Pituitary Gland of Weaned Gilts [PDF]

Toxins
Zearalenone (ZEA) is a potent estrogenic mycotoxin known to disrupt reproductive functions, but its precise central neuroendocrine mechanisms remain unclear.
Zixue Yuan, Min Zhou, Yue Luan, Lei Kong, Weiren Yang, Shuzhen Jiang   +5 more
doaj   +2 more sources