Results 1 to 10 of about 18,983 (127)

The GPR30 agonist G-1 promotes hair growth via Wnt/Hedgehog signaling in mice [PDF]

Frontiers in Pharmacology
BackgroundGPR30 is a membrane-associated receptor involved in rapid, non-genomic estrogen signaling. Estrogen significantly influences hair growth and susceptibility to hair loss, with differences primarily driven by hormonal factors.
Mayu Yamano, Yuto Yamanaka, Shota Nishikawa, Yuki Masujima, Ryuji Ohue-Kitano, Ikuo Kimura, Ikuo Kimura, Ikuo Kimura   +7 more
doaj   +2 more sources

Cardiovascular β-Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue. [PDF]

Compr Physiol
Estrogen modulates β‐AR signaling in a context‐dependent manner influenced by species, sex, age, tissue, and vascular health, highlighting challenges in translating findings from experimental models to human cardiovascular physiology. ABSTRACT Cardiovascular diseases remain the leading global cause of morbidity and mortality, with notable sex‐specific ...
Elsaid B, Kopaliani I, Zatschler B, Seif A, Speier S, Deussen A.   +5 more
europepmc   +2 more sources

GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain [PDF]

eLife
Neuropathic pain, a major health problem affecting 7–10% of the global population, lacks effective treatment due to its elusive mechanisms. Cholecystokinin-positive (CCK+) neurons in the spinal dorsal horn (SDH) are critical for neuropathic pain, yet the
Qing Chen, Hui Wu, Shulan Xie, Fangfang Zhu, Fang Xu, Qi Xu, Lihong Sun, Yue Yang, Linghua Xie, Jiaqian Xie, Hua Li, Ange Dai, Wenxin Zhang, Luyang Wang, Cuicui Jiao, HongHai Zhang, Xuelong Zhou, Zhen-Zhong Xu, Xinzhong Chen   +18 more
doaj   +2 more sources

Potential Roles of G Protein-Coupled Receptor 30 (GPR30) in Migraine Pathophysiology [PDF]

Journal of Pain Research
Yuning Yao,1 Yang Gong,1,* Kegang Cao2,* 1Department of Traditional Chinese Medicine, General Hospital of the PLA Northern Theater Command, Shenyang, Liaoning, People’s Republic of China; 2Department of Neurology, Dongzhimen Hospital of ...
Yao Y, Gong Y, Cao K
doaj   +2 more sources

Tranexamic acid protects human dermal fibroblasts from D-galactose-induced senescence via the GPR30/MAPK pathway [PDF]

Annals of Medicine
Background Tranexamic acid (TXA) is widely used for pigmentary disorders, but its anti-ageing potential remains unclear. This study aimed to evaluate whether topical 3% TXA improves early periorbital wrinkles in women with facial melasma and to ...
Yanyan Lin, Yaling Wang, Wanjing Wang, Zhili Deng, Yiya Zhang, Yiran Peng, Jin Tang, Ji Li, Chuchu Huang, Dan Jian   +9 more
doaj   +2 more sources

Effects of Zearalenone on the Kiss1/GPR54 System and Related Genes Expression in the Hypothalamus and Pituitary Gland of Weaned Gilts [PDF]

Toxins
Zearalenone (ZEA) is a potent estrogenic mycotoxin known to disrupt reproductive functions, but its precise central neuroendocrine mechanisms remain unclear.
Zixue Yuan, Min Zhou, Yue Luan, Lei Kong, Weiren Yang, Shuzhen Jiang   +5 more
doaj   +2 more sources

Estrogen Replacement Therapy in Ovariectomized Rats: Complementary Roles of ER and GPR30 in Alleviating Depressive-like Behavior [PDF]

Current Issues in Molecular Biology
Women are twice as likely to suffer from major depressive disorder (MDD). The underlying mechanism between estrogen and depression is still unknown. We used ovariectomized rats to simulate menopausal status and established a depression model of chronic ...
Siyi He, Zhongyu Ren, Lan Wu, Yinping Xie, Limin Sun, Ling Xiao, Gaohua Wang   +6 more
doaj   +2 more sources

G Protein-Coupled Receptor 30 Attenuates Neuronal Pyroptosis Induced by Subarachnoid Hemorrhage [PDF]

Mediators of Inflammation
Conclusion: GPR30 mitigates NLRC4- and IFI16-driven neuronal pyroptosis in SAH by modulating TLR4/NF-κB signaling. Pharmacological targeting of GPR30 represents a promising therapeutic strategy to ameliorate SAH-associated brain injury.
Jun Peng, Xiqi Hu, Jun He, Ying Xia
doaj   +2 more sources

GPR30-mediated NETs degradation via Trex1 in heart failure of aged female mice [PDF]

Journal of Translational Medicine
Background The occurrence of cardiovascular diseases increases dramatically in postmenopausal aged women. Accumulating evidence has indicated that estrogen protects hearts from cardiovascular diseases.
Shuaishuai Zhang, Zilin Li, Xiaoya Wang, Xiaowu Wang, Jun Du, Jiaqi Liu, Zhirong Cheng, Diancai Zhao, Weixun Duan, Jipeng Ma, Jincheng Liu   +10 more
doaj   +2 more sources

Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury [PDF]

Nature Communications
Homoeostatic regulation of the acid–base balance is essential for cellular functional integrity. However, little is known about the molecular mechanism through which the acid–base balance regulates cellular responses.
Airi Jo-Watanabe, Toshiki Inaba, Takahiro Osada, Ryota Hashimoto, Tomohiro Nishizawa, Toshiaki Okuno, Sayoko Ihara, Kazushige Touhara, Nobutaka Hattori, Masatsugu Oh-Hora, Osamu Nureki, Takehiko Yokomizo   +11 more
doaj   +2 more sources