Results 41 to 50 of about 22,632 (211)

GPR30 regulates the EGFR-Akt cascade and predicts lower survival in patients with ovarian cancer

Journal of Ovarian Research, 2012
Objectives G protein-coupled receptor 30 (GPR30) is a 7-transmembrane estrogen receptor that functions alongside traditional estrogen receptors to regulate the cellular responses to estrogen.
Fujiwara Satoe, Terai Yoshito, Kawaguchi Hiroshi, Takai Masaaki, Yoo Saha, Tanaka Yoshimichi, Tanaka Tomohito, Tsunetoh Satoshi, Sasaki Hiroshi, Kanemura Masanori, Tanabe Akiko, Yamashita Yoshiki, Ohmichi Masahide   +12 more
doaj   +1 more source

GPER and Testicular Germ Cell Cancer

Frontiers in Endocrinology, 2021
The G protein-coupled estrogen receptor (GPER), also known as GPR30, is a widely conserved 7-transmembrane-domain protein which has been identified as a novel 17β-estradiol-binding protein that is structurally distinct from the classic oestrogen ...
Nicolas Chevalier, Nicolas Chevalier, Charlotte Hinault, Charlotte Hinault, Stephan Clavel, Rachel Paul-Bellon, Patrick Fenichel, Patrick Fenichel   +7 more
doaj   +1 more source

Triple negative breast cancer: new perspectives for targeted therapies [PDF]

, 2015
Breast cancer is a heterogeneous disease, encompassing a large number of entities showing different morphological features and having clinical behaviors.
Caruso, Davide, Frati, Luigi, Minozzi, Marina, Papa, Anselmo, Rossi, Luigi, Tomao, Federica, Tomao, Silverio, Vici, Patrizia, Zaccarelli, Eleonora   +8 more
core   +1 more source

The Cell Surface Estrogen Receptor, G Protein- Coupled Receptor 30 (GPR30), is Markedly down Regulated during Breast Tumorigenesis

Breast Cancer: Basic and Clinical Research, 2008
Background GPR30 is a cell surface estrogen receptor that has been shown to mediate a number of non-genomic rapid effects of estrogen and appear to balance the signaling of estrogen and growth factors.
Indira Poola Ph.D, Jessy Abraham, Aiyi Liu, Josephine J. Marshalleck, Robert L. Dewitty   +4 more
doaj   +2 more sources

Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS [PDF]

, 2017
Estrogens play a key role in regulating reproductive and neuroendocrine function by activating classical nuclear steroid receptors that act as ligand gated transcription factors.
Abdelhamid, Adams, Akama, Al-Sweidi, Almey, Almey, Almey, Amy Alexander, Andrew J. Irving, Ariazi, Bliss, Bologa, Bourque, Brailoiu, Brinton, Briz, Briz, Chen, Choleris, Collingridge, Daniel, Davis, Dennis, Ding, Dubal, Ervin, Evans, Filardo, Filardo, Filardo, Foy, Frick, Frick, Fukazawa, Fukuda, Funakoshi, Gabor, Geary, Gibbs, Gibbs, Gillies, Gingerich, Gould, Gros, Gruber, Hall, Hammond, Hammond, Hammond, Hawley, Hazell, Isensee, Jenni Harvey, Kang, Kastenberger, Kastenberger, Kelly, Kramár, Kretz, Kwon, Lagrange, Langer, Lebesgue, Levin, Liu, Liu, Liu, Magalhaes, Maggiolini, Man, Marin, McEwen, McEwen, Micevych, Milner, Milner, Mitterling, Moga, Mukai, Murakami, Mårtensson, Nilsson, Noel, Otto, Park, Petrie, Potier, Prossnitz, Prossnitz, Prossnitz, Qiu, Revankar, Romeo, Rudolf, Ruiz-Palmero, Ruiz-Palmero, Sanchez, Sellers, Simpkins, Simpkins, Smejkalova, Smith, Smith, Smith, Sortino, Srivastava, Srivastava, Srivastava, Srivastava, Sudo, Sun, Tada, Thomas, Thomas, Thomas, Tsai, Vasudevan, Walf, Walf, Wang, Waters, Woolley, Woolley, Zadran, Zhang, Zhang, Zhou, Zhou, Zhou   +128 more
core   +2 more sources

Inactivation of GPR30 reduces growth of triple-negative breast cancer cells: possible application in targeted therapy [PDF]

, 2012
Triple-negative breast cancers lack estrogen receptor α (ERα), progesterone receptor, and do not overexpress human epidermal growth factor receptor 2 (Her-2).
Carsten Gründker, Günter Emons, Rainer Girgert   +2 more
core   +1 more source

Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer

Journal of International Medical Research, 2018
Objective To demonstrate the correlation between nuclear and cytoplasmic G protein-coupled oestrogen receptor (GPR30) expression and clinicopathological features and outcome in patients with ovarian cancer.
Cai-xia Zhu, Wei Xiong, Ma-lie Wang, Juan Yang, Hui-juan Shi, Han-qing Chen, Gang Niu   +6 more
doaj   +1 more source

Structural and functional evidence that GPR30 is not a direct estrogen receptor. [PDF]

Cell Res
Liu H, Guo S, Dai A, Xu P, Li X, Huang S, He X, Wu K, Zhang X, Yang D, Xie X, Xu HE.   +11 more
europepmc   +3 more sources

GPER/GPR30 and Regulation of Vascular Tone and Blood Pressure [PDF]

Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry, 2011
Natural estrogens such as 17β-estradiol are endogenous vasodilators and have been implicated in the gender differences of hypertension. These hormones activate estrogen receptors ERα and ERβ, which mediate part of estrogen-dependent vasodilation. In addition, a novel G protein-coupled estrogen-binding receptor termed GPER/GPR30 has been identified that
Meyer MR, Prossnitz ER, Barton M
openaire   +3 more sources

Estrogen induces two distinct cholesterol crystallization pathways by activating ERα and GPR30 in female mice

Journal of Lipid Research, 2015
To distinguish the lithogenic effect of the classical estrogen receptor α (ERα) from that of the G protein-coupled receptor 30 (GPR30), a new estrogen receptor, on estrogen-induced gallstones, we investigated the entire spectrum of cholesterol ...
Ornella de Bari, Tony Y. Wang, Min Liu, Piero Portincasa, David Q-H. Wang   +4 more
doaj   +1 more source