Results 61 to 70 of about 22,632 (211)

Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy [PDF]

, 2017
BackgroundApolipoprotein E (ApoE) is a multifunctional protein, and its deficiency leads to the development of atherosclerosis in mice. Patients with pulmonary hypertension (PH) have reduced expression of ApoE in lung tissue.
Andrea Iorga, Gregoire Ruffenach, Mansoureh Eghbali, Rod Partow-Navid, Shayan Moazeni, Soban Umar   +5 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

GPR30 receptor promotes preoperative anxiety-induced postoperative hyperalgesia by up-regulating GABAA-α4β1δ subunits in periaqueductal gray in female rats

BMC Anesthesiology, 2020
Background G-protein coupled estrogen receptor 30 (GPR30) was proved the specific estrogen receptor relating to mechanical hyperalgesia. Studies have shown that the GABAA receptor subunits α4, β1, and δ in the periaqueductal gray (PAG) neurons promote ...
Ming Jiang, Yu’e Sun, Yishan Lei, Fan Hu, Zhengrong Xia, Yue Liu, Zhengliang Ma, Xiaoping Gu   +7 more
doaj   +1 more source

The Endocrine Disrupting Compounds Bisphenol‐A and α‐Zeranol Mimic the Estrogen Transcriptional Program to Promote Proliferation and Stemness in Breast Cancer Cells

Molecular Carcinogenesis, EarlyView.
ABSTRACT Excessive activation of the estrogen receptor (ER) drives proliferation, progression, and the formation of breast cancer stem cells (CSCs) in ER‐positive breast cancer. Estrogenic endocrine disrupting compounds (EDCs) found in plastics, water, and food are also able to bind to the ER.
Cassandra Winz, Eric Li, Caroline Xie, Kyo Chang Lee, Kevin Boguszewski, Shlok Rohatagi, Rita Hahn, Ray Rancourt, Philip Furmanski, Nanjoo Suh   +9 more
wiley   +1 more source

Aldosterone rapidly activates p-PKC delta and GPR30 but suppresses p-PKC epsilon protein levels in rat kidney

Endocrine Regulations, 2019
Objectives. Aldosterone rapidly enhances protein kinase C (PKC) alpha and beta1 proteins in the rat kidney. The G protein-coupled receptor 30 (GPR30)-mediated PKC pathway is involved in the inhibition of the potassium channel in HEK-239 cells.
Eiam-Ong Somchit, Chaipipat Mookda, Manotham Krissanapong, Eiam-Ong Somchai   +3 more
doaj   +1 more source

G-protein-coupled estrogen receptor-30 gene polymorphisms are associated with uterine leiomyoma risk

Biomolecules & Biomedicine, 2016
The G-protein-coupled estrogen receptor (GPR30, GPER-1) is a member of the G-protein-coupled receptor 1 family and is expressed significantly in uterine leiomyomas. To understand the relationship between GPR30 single nucleotide polymorphisms and the risk
Burcu Kasap, Nilgün Öztürk Turhan, Tuba Edgünlü, Müzeyyen Duran, Eren Akbaba, Gökalp Öner   +5 more
doaj   +1 more source

Rapid Nongenomic Effects of Oestradiol on Gonadotrophin‐Releasing Hormone Neurones [PDF]

, 2012
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/89550/1/j.1365-2826.2011.02135.x ...
Abe, Abe, Abraham, Abraham, Christian, Christian, Christian, Christian, Christian, Christian, Christian, Chu, Chu, Clarke, DeFazio, Docke, Heldring, Herbison, Herbison, Hrabovszky, Hu, Kelly, Kelly, Kelly, Lagrange, Lalmansingh, Levin, Mendelsohn, Moenter, Moenter, Navarro, Nelson, Noel, Qiu, Revankar, Romano, Spergel, Sun, Suter, Temple, Terasawa, Toran-Allerand, Wintermantel, Woolley, Zhang, Zhang   +45 more
core   +1 more source

The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation

Journal of Neuroinflammation, 2018
Background The steroid hormone estrogen (17-β-estradiol, E2) provides neuroprotection against cerebral ischemic injury by activating estrogen receptors.
Zengli Zhang, Pei Qin, Youliang Deng, Zhi Ma, Hang Guo, Haiyun Guo, Yushu Hou, Shiquan Wang, Wangyuan Zou, Yanyuan Sun, Yulong Ma, Wugang Hou   +11 more
doaj   +1 more source

Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study. [PDF]

, 2016
Gonadotropin-releasing hormone (GnRH) neurons are controlled by 17beta-estradiol (E2) contributing to the steroid feedback regulation of the reproductive axis.
Bálint, Flóra, Farkas, Imre, Liposits, Zsolt   +2 more
core   +1 more source

Equol Alleviates Postmenopausal Metabolic Dysfunction‐Associated Steatotic Liver Disease via the GPR30/PI3K Pathway

eFood, Volume 7, Issue 3, June 2026.
This study demonstrates that equol exerts a protective effect on metabolic dysfunction‐associated steatotic liver disease in both in vivo and in vitro by activating the GPR30/PI3K/Nrf2 signaling pathway. Equol's interaction with GPR30 and its ability to activate the PI3K/Nrf2 pathway provide a promising therapeutic strategy for treating metabolic ...
Hanqiang Cui, Bin Wang, Bo Zou, Guiming Zhang, Zhe Xu, Shuo Li, Jing Xu, Xiangmin Ni, Jian Wang   +8 more
wiley   +1 more source