Results 61 to 70 of about 19,033 (167)

Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay

Frontiers in Oncology, 2020
It is of utmost importance to decipher the role of chronic exposure to low doses of environmental carcinogens on breast cancer progression. The early-transformed triple-negative human mammary MCF10AT1 cells were chronically (60 days) exposed to low doses
Caterina F. Donini, Caterina F. Donini, Caterina F. Donini, Myriam El Helou, Myriam El Helou, Myriam El Helou, Anne Wierinckx, Anne Wierinckx, Anne Wierinckx, Balázs Győrffy, Sophie Aires, Sophie Aires, Aurélie Escande, Séverine Croze, Séverine Croze, Philippe Clezardin, Philippe Clezardin, Joël Lachuer, Joël Lachuer, Joël Lachuer, Mona Diab-Assaf, Sandra E. Ghayad, Béatrice Fervers, Béatrice Fervers, Béatrice Fervers, Vincent Cavaillès, Véronique Maguer-Satta, Pascale A. Cohen, Pascale A. Cohen, Pascale A. Cohen, Pascale A. Cohen, Pascale A. Cohen   +31 more
doaj   +1 more source

Estrogen regulates hepcidin expression via GPR30-BMP6-dependent signaling in hepatocytes. [PDF]

PLoS ONE, 2012
Hepcidin, a liver-derived iron regulatory protein, plays a crucial role in iron metabolism. It is known that gender differences exist with respect to iron storage in the body; however, the effects of sex steroid hormones on iron metabolism are not ...
Yasumasa Ikeda, Soichiro Tajima, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Keisuke Ishizawa, Shuhei Tomita, Koichiro Tsuchiya, Toshiaki Tamaki   +7 more
doaj   +1 more source

Anticancer Molecular Mechanisms of Phytosterols: An Updated Review on Clinical Trials

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Phytosterols, a form of naturally occurring substance structurally related to cholesterol, have been getting considerable interest due to their possible anticancer properties. Phytosterols induce apoptosis, block the cell cycle, and abrogate the invasion and metastasis of cancer cells, offering a multi‐manifestation treatment of cancer.
Muhammad Shahbaz, Ushna Momal, Asfa Perween, Hammad Naeem, Muzzamal Hussain, Muhammad Imran, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Suliman A. Alsagaby, Waleed Al Abdulmonem, Entessar Al Jbawi, Mohamed A. Abdelgawad, Samy Selim, Soad K. Al Jaouni, Hagar M. Mohamed   +14 more
wiley   +1 more source

Detection of the Phosphorylation of the Estrogen Receptor α as an Outcome of GPR30 Activation [PDF]

, 2016
Phosphorylation of the serine residues in estrogen receptor (ER) α is important in transcriptional activation. Hence, methods to detect such posttranslational modification events are valuable. We describe, in detail, the analysis of the phosphorylated ERα by electrophoretic separation of proteins and subsequent immuno-blotting techniques. In particular,
Clark, Sara, Pollard, Kevin, Rainville, Jennifer, Vasudevan, Nandini   +3 more
openaire   +2 more sources

Differences in GPR30 Regulation by Chlorotriazine Herbicides in Human Breast Cells [PDF]

Biochemistry Research International, 2016
Over 200,000 cases of invasive breast cancer are diagnosed annually; herbicide contaminants in local water sources may contribute to the growth of these cancers. GPR30, a G protein coupled receptor, was identified as a potential orphan receptor that may interact with triazine herbicides such as atrazine, one of the most commonly utilized ...
Colin P. Florian, Shelly R. Mansfield, Jennifer R. Schroeder   +2 more
openaire   +3 more sources

Chronic activation of the G protein-coupled receptor 30 with agonist G-1 attenuates heart failure.

PLoS ONE, 2012
G protein-coupled receptor (GPR) 30 is a novel estrogen receptor. Recent studies suggest that activation of the GPR30 confers rapid cardioprotection in isolated rat heart.
Shoulei Kang, Ying Liu, Di Sun, Chunle Zhou, Aiying Liu, Chuanying Xu, Yanling Hao, Dongye Li, Changdong Yan, Hong Sun   +9 more
doaj   +1 more source

Steroid Hormones Are Potent and Putatively Endogenous Activators of Human Bitter Taste Receptors

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
Human bitter taste receptors are not only involved in sensing tastants within the oral cavity but also play crucial roles in internal tissues of the body. The current report identifies numerous structurally and functionally diverse steroid hormones as activators of the two human bitter taste receptors, TAS2R14 and TAS2R46.
Tatjana Lang, Francesco Ferri, Florian Ziegler, Antonella Di Pizio, Maik Behrens   +4 more
wiley   +1 more source

GPR30 Gene Polymorphisms Are Associated with Gynecomastia Risk in Adolescents

Hormone Research in Paediatrics, 2014
The G protein-coupled receptor, GPR30, which is a third estrogen receptor, has been shown to mediate estrogenic effects on the essential features of human breast cancer cells. The aim of this study was to evaluate the association between GPR30 single nucleotide polymorphisms and gynecomastia in males.This study included 109 male adolescents with ...
EREN, ERDAL, Ozkan, Behzat, Celik, Sevim Karakas, Cakir, Esra Deniz Papatya, Demir, Korcan, Edgunlu, Tuba, Korkmaz, Huseyin Anil   +6 more
openaire   +5 more sources

Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling

Journal of Experimental & Clinical Cancer Research, 2017
Background Clinically, breast cancer is generally classified into estrogen receptor-positive (ER+) or estrogen receptor-negative (ER−) subtypes. The phytoestrogen calycosin has been shown to inhibit the proliferation of ER+ cells, which may be mediated ...
Jing Tian, Yong Wang, Xing Zhang, Qianyao Ren, Rong Li, Yue Huang, Huiling Lu, Jian Chen   +7 more
doaj   +1 more source

Discovery of new receptors regulating luteinizing hormone and follicle-stimulating hormone secretion by bovine gonadotrophs to explore a new paradigm for mechanisms regulating reproduction

The Journal of Reproduction and Development, 2020
Previous studies in the 1960s and 1970s have reported that both gonadotropin-releasing hormone (GnRH) and estradiol-activated nuclear estrogen receptors regulate gonadotropin secretion in women.
Hiroya KADOKAWA
doaj   +1 more source