Results 51 to 60 of about 22,632 (211)
GPER-1 acts as a tumor suppressor in ovarian cancer [PDF]
, 2013 Background: It is known that the new membrane-bound estrogen receptor GPER-1 acts suppressive in breast cancer cells and its expression decreases during disease progression.
Costa, Serban-Dan +9 more
core +2 more sources
Frontiers in Endocrinology, 2022 Thermogenic adipocytes possess a promising approach to combat obesity with its capability promoting energy metabolism. We previously discovered that deletion of GPR30 (GPRKO), a presumably membrane-associated estrogen receptor, protected female mice from
Jing Luo +4 more
doaj +1 more source
GPR30 activation decreases anxiety in the open field test but not in the elevated plus maze test in female mice [PDF]
, 2013 The GPR30 is a novel estrogen receptor (ER) that is a candidate membrane ER based on its binding to 17beta estradiol and its rapid signaling properties such as activation of the extracellular-regulated kinase (ERK) pathway.
Anchan, Divya +3 more
core +1 more source
Mechanisms of estrogen signaling and gene expression via GPR30 [PDF]
Molecular and Cellular Endocrinology, 2009 The effects of estrogen are widespread throughout the body. Although the classical nuclear estrogen receptors have been known for many years to decades and their primary modes of action as transcriptional regulators is well understood, certain aspects of estrogen biology remain inconsistent with the mechanisms of action of these receptor. More recently,
Prossnitz ER, MAGGIOLINI, Marcello
openaire +3 more sources
Journal of Pharmacological Sciences, 2016 Membrane-associated estrogen receptor “G protein-coupled receptor 30” (GPR30) has been implicated in spatial recognition memory and protection against neuronal death.
Takashi Kubota +2 more
doaj +1 more source
GPER/GPR30 Knockout Mice: Effects of GPER on Metabolism [PDF]
, 2016 Endogenous estrogens, predominantly 17β-estradiol (E2), mediate various diverse effects throughout the body in both normal physiology and disease. Actions include development (including puberty) and reproduction as well as additional effects throughout life in the metabolic, endocrine, musculoskeletal, nervous, cardiovascular, and immune systems.
Geetanjali, Sharma, Eric R, Prossnitz
openaire +2 more sources
Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking [PDF]
, 2015 Sex differences have been widely reported in neuroinflammatory disorders, focusing on the contributory role of estrogen. The microvascular endothelium of the brain is a critical component of the blood–brain barrier (BBB) and it is recognized as a major ...
Abbott +55 more
core +3 more sources
Frontiers in Pharmacology, 2021 The incidence of cardiovascular diseases was significantly increased in postmenopausal women. The protection of estrogen in the cardiovascular system has been further reported for decades.
Xiaowu Wang +7 more
doaj +1 more source
Cytosolic phospholipase A2 activation correlates with HER2 overexpression and mediates estrogen-dependent breast cancer cell growth. [PDF]
, 2010 Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) catalyzes the hydrolysis of membrane glycerol-phospholipids to release arachidonic acid as the first step of the eicosanoid signaling pathway.
Caiazza, Francesco +2 more
core +1 more source
Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of the transient receptor potential A1 (TRPA1) channel [PDF]
, 2019 Estrogen hormones play an important role in controlling glucose homeostasis and pancreatic β-cell function. Despite the significance of estrogen hormones for regulation of glucose metabolism, little is known about the roles of endogenous estrogen ...
Cabrera, Over +7 more
core +1 more source