Results 71 to 80 of about 19,033 (167)

Structural and functional evidence that GPR30 is not a direct estrogen receptor. [PDF]

Cell Res
Liu H, Guo S, Dai A, Xu P, Li X, Huang S, He X, Wu K, Zhang X, Yang D, Xie X, Xu HE.   +11 more
europepmc   +3 more sources

Biochemical and Comparative Proteomic Analyses Delineate the Anti‐Ovarian Carcinogenic Roles of Modified Calycosin

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The modified calycosin derivative H10 was more effective in inhibiting cell proliferation through G0/G1 cell cycle arrest, together with inhibiting the migration and colony formation abilities of ovarian cancer cell lines SKOV3 and A2780. Comparative proteomic analysis coupled with Ingenuity Pathway Analysis further delineated calycosin derivative H10 ...
Fuhong Yang, Xin Li, Hanchi Gao, Pei Yao, Xian Qin, Xiao Lin, Keng Po Lai, Jing Tian, Jian Chen   +8 more
wiley   +1 more source

Improvement of vascular function by acute and chronic treatment with the GPR30 agonist G1 in experimental diabetes mellitus.

PLoS ONE, 2012
The G-protein coupled estrogen receptor 30 (GPR30) is a seven-transmembrane domain receptor that mediates rapid estrogen responses in a wide variety of cell types.
Zi-lin Li, Jin-cheng Liu, Shui-bing Liu, Xiao-qiang Li, Ding-hua Yi, Ming-gao Zhao   +5 more
doaj   +1 more source

24R,25(OH)2D3 regulates tumorigenesis in estrogen sensitive laryngeal cancer cells via membrane‐associated receptor complexes in ER+ and ER− cells

International Journal of Cancer, Volume 158, Issue 1, Page 202-217, 1 January 2026.
What's new? Estrogen receptors likely influence the development of laryngeal cancer and are of particular interest in regard to their relationship with the vitamin D metabolite 24R,25(OH)2D3. In this study the authors examined interactions between 24R,25(OH)2D3 and estrogen‐responsive laryngeal tumorigenesis.
Cydney D. Dennis, D. Joshua Cohen, Kusal Debnath, Nofrat Schwartz, Brock P. Lodato, Jonathan T. Dillon, Tillat Batool, Matthew S. Halquist, Preetam Ghosh, Zvi Schwartz, Barbara D. Boyan   +10 more
wiley   +1 more source

A sex‐specific “hormone–bone–brain” axis in Alzheimer's disease: Integrating Global Burden of Disease data and Mendelian randomization analysis to reveal the causal role of osteocalcin

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract BACKGROUND Alzheimer's disease (AD) shows a significant sex disparity, with a higher incidence in women. Although reduced estradiol (E2) is a conventional explanation, inconsistent hormone‐replacement therapy outcomes suggest that other regulators, like the postmenopausal rise in follicle‐stimulating hormone (FSH), may be involved.
Zhiyang Zheng, Yifan Ren, Jingzhe Gao, Jianglong Chen, Ke Yuan, Zhongqiang Zhang, Zhigang Wang, Xia Lei, Yafeng Zhang, Hao Ai, Fang Geng, Ning Zhang, Hongdan Xu   +12 more
wiley   +1 more source

The role of GPR30 in breast cancer cell migration

The FASEB Journal, 2012
Some cells, although lacking the canonical estrogen receptors (ERs) still display rapid non‐genomic signalling in response to estrogen. Recently, a G protein coupled receptor; GPR30 (or GPER) and an alternative splice variant of the traditional ERα (ERα36) have been proposed as alternative estrogen receptors that may mediate these non‐genomic effects ...
Heather Doran, Ruth A Ross
openaire   +1 more source

Risk Factor Analysis Based on Disease Severity: Rosacea Disease Management Strategies and Personalized Recommendations

Journal of Cosmetic Dermatology, Volume 25, Issue 1, January 2026.
ABSTRACT Background Rosacea is a common chronic inflammatory skin disease with complex causes and varied clinical manifestations. While risk factors for its onset have been studied, key factors associated with disease severity remain unclear. Identifying these factors is essential for optimizing management and treatment strategies. Aims This study aims
Hongshan Liu, Luyue Zhang, Jianing Yuan, Jingchen Liang, Yuxin Zhang, Ziyun Gao, Ying Chen, Yawen Wang, Youbao Li, Weihui Zeng, Fan Yang   +10 more
wiley   +1 more source

Inhibitory effect of oestradiol on the cardiac KV7.1/KCNE1 channel is species dependent

Experimental Physiology, Volume 111, Issue 1, Page 54-68, 1 January 2026.
Abstract Oestradiol (17β‐E2) is reported to prolong the cardiac action potential duration and QT interval, in part by affecting cardiac ion channels. Previous studies found inhibiting 17β‐E2 effects on the repolarizating cardiac KV7.1/KCNE1 channel, or its native current, in heterologous expression systems or tissue from animal species.
Veronika A. Linhart, Lucas Dauga, Sara I. Liin   +2 more
wiley   +1 more source

The role of UPR‐related long noncoding RNAs in development of endocrine resistance in breast cancer

International Journal of Cancer, Volume 157, Issue 12, Page 2434-2446, 15 December 2025.
Abstract Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first‐line treatment. Most ER‐positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways.
Wen Liu, Sahil Gupta, Sanjeev Gupta
wiley   +1 more source

Genistein, a Phytoestrogen in Soybean, Induces the Expression of Acetylcholinesterase via G Protein-Coupled Receptor 30 in PC12 Cells

Frontiers in Molecular Neuroscience, 2018
Genistein, 4′,5,7-trihydroxyisoflavone, is a major isoflavone in soybean, which is known as phytestrogen having known benefit to brain functions. Being a common phytestrogen, the possible role of genistein in the brain protection needs to be further ...
Etta Y. L. Liu, Etta Y. L. Liu, Miranda L. Xu, Miranda L. Xu, Yan Jin, Yan Jin, Qiyun Wu, Qiyun Wu, Tina T. X. Dong, Tina T. X. Dong, Karl W. K. Tsim, Karl W. K. Tsim   +11 more
doaj   +1 more source