Results 81 to 90 of about 22,632 (211)

Estrogen/GPR30 Signaling Contributes to the Malignant Potentials of ER-Negative Cervical Adenocarcinoma via Regulation of Claudin-1 Expression

Neoplasia: An International Journal for Oncology Research, 2018
Cervical adenocarcinomas are believed to lose estrogen response on the basis of no expression of a nuclear estrogen receptor such as ERα in clinical pathology.
Taishi Akimoto, Akira Takasawa, Kumi Takasawa, Tomoyuki Aoyama, Masaki Murata, Makoto Osanai, Tsuyoshi Saito, Norimasa Sawada   +7 more
doaj   +1 more source

The Role of Endocrine G Protein-Coupled Receptors in Ovarian Cancer Progression [PDF]

, 2017
published_or_final_versio
Chow, BKC, Lee, LTO, Madden, NE, Wong, AST, Zhang, Q   +4 more
core   +1 more source

Anticancer Molecular Mechanisms of Phytosterols: An Updated Review on Clinical Trials

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Phytosterols, a form of naturally occurring substance structurally related to cholesterol, have been getting considerable interest due to their possible anticancer properties. Phytosterols induce apoptosis, block the cell cycle, and abrogate the invasion and metastasis of cancer cells, offering a multi‐manifestation treatment of cancer.
Muhammad Shahbaz, Ushna Momal, Asfa Perween, Hammad Naeem, Muzzamal Hussain, Muhammad Imran, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Suliman A. Alsagaby, Waleed Al Abdulmonem, Entessar Al Jbawi, Mohamed A. Abdelgawad, Samy Selim, Soad K. Al Jaouni, Hagar M. Mohamed   +14 more
wiley   +1 more source

G protein-coupled receptor 30 activation inhibits ferroptosis and protects chondrocytes against osteoarthritis

Journal of Orthopaedic Translation
Background: Osteoarthritis (OA) is the most common joint disease worldwide, but its cause remains unclear. Oestrogen protects against OA, but its clinical use is limited. G protein-coupled receptor 30 (GPR30) is a receptor that binds oestrogen, and GPR30
Zhen Zhao, Shun Niu, Jun Chen, Hongtao Zhang, Lizuo Liang, Kui Xu, Chuan Dong, Chang Su, Tao Yan, Yongqiang Zhang, Hua Long, Le Yang, Minggao Zhao   +12 more
doaj   +1 more source

Estrogen regulates hepcidin expression via GPR30-BMP6-dependent signaling in hepatocytes. [PDF]

PLoS ONE, 2012
Hepcidin, a liver-derived iron regulatory protein, plays a crucial role in iron metabolism. It is known that gender differences exist with respect to iron storage in the body; however, the effects of sex steroid hormones on iron metabolism are not ...
Yasumasa Ikeda, Soichiro Tajima, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Keisuke Ishizawa, Shuhei Tomita, Koichiro Tsuchiya, Toshiaki Tamaki   +7 more
doaj   +1 more source

GPR30 as an initiator of tamoxifen resistance in hormone-dependent breast cancer [PDF]

Breast Cancer Research, 2013
Abstract Introduction Tamoxifen is widely used to treat hormone-dependent breast cancer, but its therapeutic benefit is limited by the development of drug resistance. Here, we investigated the role of estrogen G-protein coupled receptor 30 (GPR30) on Tamoxifen resistance in breast cancer.
Mo, Zhiqiang, Liu, Manran, Yang, Fangfang, Luo, Haojun, Li, Zhenhua, Tu, Gang, Yang, Guanglun   +6 more
openaire   +2 more sources

Estrogen activation of microglia underlies the sexually dimorphic differences in Nf1 optic glioma-induced retinal pathology [PDF]

, 2016
Children with neurofibromatosis type 1 (NF1) develop low-grade brain tumors throughout the optic pathway. Nearly 50% of children with optic pathway gliomas (OPGs) experience visual impairment, and few regain their vision after chemotherapy.
Anne C. Solga, Arnold, Avery, Azevedo, Bajenaru, Bondesson, Compton, Daginakatte, Daginakatte, David H. Gutmann, Dennis, Diggs-Andrews, Diggs-Andrews, Fisher, Fisher, Green, Gu, Guadagno, Hegedus, Hyman, Joseph A. Toonen, Kalin-Hajdu, Kappeler, Kuiper, Listernick, Listernick, Neher, Parrilla-Reverter, Revankar, Saijo, Schneider, Simmons, Solga, Tapia-Gonzalez, Tikka, Wu, Yu Ma, Zhao   +37 more
core   +2 more sources

Steroid Hormones Are Potent and Putatively Endogenous Activators of Human Bitter Taste Receptors

Annals of the New York Academy of Sciences, Volume 1556, Issue 1, February 2026.
Human bitter taste receptors are not only involved in sensing tastants within the oral cavity but also play crucial roles in internal tissues of the body. The current report identifies numerous structurally and functionally diverse steroid hormones as activators of the two human bitter taste receptors, TAS2R14 and TAS2R46.
Tatjana Lang, Francesco Ferri, Florian Ziegler, Antonella Di Pizio, Maik Behrens   +4 more
wiley   +1 more source

Chronic activation of the G protein-coupled receptor 30 with agonist G-1 attenuates heart failure.

PLoS ONE, 2012
G protein-coupled receptor (GPR) 30 is a novel estrogen receptor. Recent studies suggest that activation of the GPR30 confers rapid cardioprotection in isolated rat heart.
Shoulei Kang, Ying Liu, Di Sun, Chunle Zhou, Aiying Liu, Chuanying Xu, Yanling Hao, Dongye Li, Changdong Yan, Hong Sun   +9 more
doaj   +1 more source

Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay

Frontiers in Oncology, 2020
It is of utmost importance to decipher the role of chronic exposure to low doses of environmental carcinogens on breast cancer progression. The early-transformed triple-negative human mammary MCF10AT1 cells were chronically (60 days) exposed to low doses
Caterina F. Donini, Caterina F. Donini, Caterina F. Donini, Myriam El Helou, Myriam El Helou, Myriam El Helou, Anne Wierinckx, Anne Wierinckx, Anne Wierinckx, Balázs Győrffy, Sophie Aires, Sophie Aires, Aurélie Escande, Séverine Croze, Séverine Croze, Philippe Clezardin, Philippe Clezardin, Joël Lachuer, Joël Lachuer, Joël Lachuer, Mona Diab-Assaf, Sandra E. Ghayad, Béatrice Fervers, Béatrice Fervers, Béatrice Fervers, Vincent Cavaillès, Véronique Maguer-Satta, Pascale A. Cohen, Pascale A. Cohen, Pascale A. Cohen, Pascale A. Cohen, Pascale A. Cohen   +31 more
doaj   +1 more source