Results 91 to 100 of about 22,632 (211)

On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation [PDF]

, 2013
The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Fuxe, Kjell, Rivera, Alicia, Romero-Fernandez, Wilber, Tarakanov, Alexander O, Van Craenenbroeck, Kathleen   +6 more
core   +3 more sources

Biochemical and Comparative Proteomic Analyses Delineate the Anti‐Ovarian Carcinogenic Roles of Modified Calycosin

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
The modified calycosin derivative H10 was more effective in inhibiting cell proliferation through G0/G1 cell cycle arrest, together with inhibiting the migration and colony formation abilities of ovarian cancer cell lines SKOV3 and A2780. Comparative proteomic analysis coupled with Ingenuity Pathway Analysis further delineated calycosin derivative H10 ...
Fuhong Yang, Xin Li, Hanchi Gao, Pei Yao, Xian Qin, Xiao Lin, Keng Po Lai, Jing Tian, Jian Chen   +8 more
wiley   +1 more source

GPR30 Gene Polymorphisms Are Associated with Gynecomastia Risk in Adolescents

Hormone Research in Paediatrics, 2014
The G protein-coupled receptor, GPR30, which is a third estrogen receptor, has been shown to mediate estrogenic effects on the essential features of human breast cancer cells. The aim of this study was to evaluate the association between GPR30 single nucleotide polymorphisms and gynecomastia in males.This study included 109 male adolescents with ...
EREN, ERDAL, Ozkan, Behzat, Celik, Sevim Karakas, Cakir, Esra Deniz Papatya, Demir, Korcan, Edgunlu, Tuba, Korkmaz, Huseyin Anil   +6 more
openaire   +5 more sources

Is GPR30 the Membrane Aldosterone Receptor Postulated 20 Years Ago? [PDF]

Hypertension, 2011
To the Editor: Gros et al1 describe the involvement of GPR30 in rapid actions of aldosterone. The hypothesis that a structure other than the mineralocorticoid receptor (MR) may mediate rapid actions of aldosterone was postulated many years ago. Wehling et al2 showed in 1991 that the rapid effect of aldosterone on the sodium-proton exchanger in human ...
Alexandra, Wendler, Martin, Wehling
openaire   +2 more sources

24R,25(OH)2D3 regulates tumorigenesis in estrogen sensitive laryngeal cancer cells via membrane‐associated receptor complexes in ER+ and ER− cells

International Journal of Cancer, Volume 158, Issue 1, Page 202-217, 1 January 2026.
What's new? Estrogen receptors likely influence the development of laryngeal cancer and are of particular interest in regard to their relationship with the vitamin D metabolite 24R,25(OH)2D3. In this study the authors examined interactions between 24R,25(OH)2D3 and estrogen‐responsive laryngeal tumorigenesis.
Cydney D. Dennis, D. Joshua Cohen, Kusal Debnath, Nofrat Schwartz, Brock P. Lodato, Jonathan T. Dillon, Tillat Batool, Matthew S. Halquist, Preetam Ghosh, Zvi Schwartz, Barbara D. Boyan   +10 more
wiley   +1 more source

Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling

Journal of Experimental & Clinical Cancer Research, 2017
Background Clinically, breast cancer is generally classified into estrogen receptor-positive (ER+) or estrogen receptor-negative (ER−) subtypes. The phytoestrogen calycosin has been shown to inhibit the proliferation of ER+ cells, which may be mediated ...
Jing Tian, Yong Wang, Xing Zhang, Qianyao Ren, Rong Li, Yue Huang, Huiling Lu, Jian Chen   +7 more
doaj   +1 more source

Discovery of new receptors regulating luteinizing hormone and follicle-stimulating hormone secretion by bovine gonadotrophs to explore a new paradigm for mechanisms regulating reproduction

The Journal of Reproduction and Development, 2020
Previous studies in the 1960s and 1970s have reported that both gonadotropin-releasing hormone (GnRH) and estradiol-activated nuclear estrogen receptors regulate gonadotropin secretion in women.
Hiroya KADOKAWA
doaj   +1 more source

Differences in GPR30 Regulation by Chlorotriazine Herbicides in Human Breast Cells [PDF]

Biochemistry Research International, 2016
Over 200,000 cases of invasive breast cancer are diagnosed annually; herbicide contaminants in local water sources may contribute to the growth of these cancers. GPR30, a G protein coupled receptor, was identified as a potential orphan receptor that may interact with triazine herbicides such as atrazine, one of the most commonly utilized ...
Colin P. Florian, Shelly R. Mansfield, Jennifer R. Schroeder   +2 more
openaire   +3 more sources

A sex‐specific “hormone–bone–brain” axis in Alzheimer's disease: Integrating Global Burden of Disease data and Mendelian randomization analysis to reveal the causal role of osteocalcin

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract BACKGROUND Alzheimer's disease (AD) shows a significant sex disparity, with a higher incidence in women. Although reduced estradiol (E2) is a conventional explanation, inconsistent hormone‐replacement therapy outcomes suggest that other regulators, like the postmenopausal rise in follicle‐stimulating hormone (FSH), may be involved.
Zhiyang Zheng, Yifan Ren, Jingzhe Gao, Jianglong Chen, Ke Yuan, Zhongqiang Zhang, Zhigang Wang, Xia Lei, Yafeng Zhang, Hao Ai, Fang Geng, Ning Zhang, Hongdan Xu   +12 more
wiley   +1 more source

Improvement of vascular function by acute and chronic treatment with the GPR30 agonist G1 in experimental diabetes mellitus.

PLoS ONE, 2012
The G-protein coupled estrogen receptor 30 (GPR30) is a seven-transmembrane domain receptor that mediates rapid estrogen responses in a wide variety of cell types.
Zi-lin Li, Jin-cheng Liu, Shui-bing Liu, Xiao-qiang Li, Ding-hua Yi, Ming-gao Zhao   +5 more
doaj   +1 more source