Journal of Cosmetic Dermatology, Volume 25, Issue 1, January 2026.ABSTRACT Background Rosacea is a common chronic inflammatory skin disease with complex causes and varied clinical manifestations. While risk factors for its onset have been studied, key factors associated with disease severity remain unclear. Identifying these factors is essential for optimizing management and treatment strategies. Aims This study aims
Hongshan Liu +10 more
wiley +1 more source
Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30. [PDF]
PLoS ONE, 2015 The post-menopausal decrease in estrogen circulating levels results in rapid skin deterioration pointing out to a protective effect exerted by these hormones.
Julie Carnesecchi +9 more
doaj +1 more source
The role of GPR30 in breast cancer cell migration
The FASEB Journal, 2012 Some cells, although lacking the canonical estrogen receptors (ERs) still display rapid non‐genomic signalling in response to estrogen. Recently, a G protein coupled receptor; GPR30 (or GPER) and an alternative splice variant of the traditional ERα (ERα36) have been proposed as alternative estrogen receptors that may mediate these non‐genomic effects ...
Heather Doran, Ruth A Ross
openaire +1 more source
Inhibitory effect of oestradiol on the cardiac KV7.1/KCNE1 channel is species dependent
Experimental Physiology, Volume 111, Issue 1, Page 54-68, 1 January 2026.Abstract Oestradiol (17β‐E2) is reported to prolong the cardiac action potential duration and QT interval, in part by affecting cardiac ion channels. Previous studies found inhibiting 17β‐E2 effects on the repolarizating cardiac KV7.1/KCNE1 channel, or its native current, in heterologous expression systems or tissue from animal species.
Veronika A. Linhart +2 more
wiley +1 more source
Epithelial to mesenchymal transition in the pathogenesis of uterine malignant mixed Müllerian tumours: the role of ubiquitin proteasome system and therapeutic opportunities [PDF]
, 2018 Malignant mixed Müllerian tumours (malignant mixed mesodermal tumours, MMMT) of the uterus are metaplastic carcinomas with a sarcomatous component and thus they are also called carcinosarcomas.
Voutsadakis, Ioannis
core
Gonadal hormones, but not sex, affect the acquisition and maintenance of a Go/No-Go odor discrimination task in mice [PDF]
, 2018 In mice, olfaction is crucial for identifying social odors (pheromones) that signal the presence of suitable mates. We used a custom-built olfactometer and a thirst-motivated olfactory discrimination Go/No-Go (GNG) task to ask whether discrimination of ...
Bass, M. +5 more
core +1 more source
The role of UPR‐related long noncoding RNAs in development of endocrine resistance in breast cancer
International Journal of Cancer, Volume 157, Issue 12, Page 2434-2446, 15 December 2025.Abstract Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first‐line treatment. Most ER‐positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways.
Wen Liu, Sahil Gupta, Sanjeev Gupta
wiley +1 more source
Notch/neurogenin 3 signalling is involved in the neuritogenic actions of oestradiol in developing hippocampal neurones [PDF]
, 1979 10 pages. - PMID: 21251092 [PubMed - in process]The ovarian hormone oestradiol promotes neuritic outgrowth in different neuronal types, by mechanisms that remain elusive.
Ruiz-Palmero, Isabel +3 more
core +1 more source
Dualistic Roles of High Mobility Group Box 1 in Cancer and Inflammation
Cancer Medicine, Volume 14, Issue 23, December 2025.ABSTRACT Background The High Mobility Group Box 1 (HMGB1) protein, a member of the HMG family, plays a crucial role in both cancer progression and inflammatory responses. HMGB1 can act as a damage‐associated molecular pattern (DAMP) to activate immune responses and modulate inflammation.
Wen Zeng +6 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source