Results 31 to 40 of about 19,033 (167)
Breast Cancer: Basic and Clinical Research, 2008 Background GPR30 is a cell surface estrogen receptor that has been shown to mediate a number of non-genomic rapid effects of estrogen and appear to balance the signaling of estrogen and growth factors.
Indira Poola Ph.D +4 more
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Journal of Lipid Research, 2015 To distinguish the lithogenic effect of the classical estrogen receptor α (ERα) from that of the G protein-coupled receptor 30 (GPR30), a new estrogen receptor, on estrogen-induced gallstones, we investigated the entire spectrum of cholesterol ...
Ornella de Bari +4 more
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GPER/GPR30 and Regulation of Vascular Tone and Blood Pressure [PDF]
Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry, 2011 Natural estrogens such as 17β-estradiol are endogenous vasodilators and have been implicated in the gender differences of hypertension. These hormones activate estrogen receptors ERα and ERβ, which mediate part of estrogen-dependent vasodilation. In addition, a novel G protein-coupled estrogen-binding receptor termed GPER/GPR30 has been identified that
Meyer MR, Prossnitz ER, Barton M
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Frontiers in Endocrinology, 2022 Thermogenic adipocytes possess a promising approach to combat obesity with its capability promoting energy metabolism. We previously discovered that deletion of GPR30 (GPRKO), a presumably membrane-associated estrogen receptor, protected female mice from
Jing Luo +4 more
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Mechanisms of estrogen signaling and gene expression via GPR30 [PDF]
Molecular and Cellular Endocrinology, 2009 The effects of estrogen are widespread throughout the body. Although the classical nuclear estrogen receptors have been known for many years to decades and their primary modes of action as transcriptional regulators is well understood, certain aspects of estrogen biology remain inconsistent with the mechanisms of action of these receptor. More recently,
Prossnitz ER, MAGGIOLINI, Marcello
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GPER/GPR30 Knockout Mice: Effects of GPER on Metabolism [PDF]
, 2016 Endogenous estrogens, predominantly 17β-estradiol (E2), mediate various diverse effects throughout the body in both normal physiology and disease. Actions include development (including puberty) and reproduction as well as additional effects throughout life in the metabolic, endocrine, musculoskeletal, nervous, cardiovascular, and immune systems.
Geetanjali, Sharma, Eric R, Prossnitz
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Journal of Pharmacological Sciences, 2016 Membrane-associated estrogen receptor “G protein-coupled receptor 30” (GPR30) has been implicated in spatial recognition memory and protection against neuronal death.
Takashi Kubota +2 more
doaj +1 more source
Journal of International Medical Research, 2018 Objective To demonstrate the correlation between nuclear and cytoplasmic G protein-coupled oestrogen receptor (GPR30) expression and clinicopathological features and outcome in patients with ovarian cancer.
Cai-xia Zhu +6 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The incidence of cardiovascular diseases was significantly increased in postmenopausal women. The protection of estrogen in the cardiovascular system has been further reported for decades.
Xiaowu Wang +7 more
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Prostate Cancer Development, Progression, and Therapy
MedComm – Oncology, Volume 5, Issue 3, September 2026.This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin +9 more
wiley +1 more source