Results 11 to 20 of about 19,033 (167)

Cryo-EM structure of the bicarbonate receptor GPR30

eLife
G-protein-coupled receptor 30 (GPR30) is a bicarbonate receptor that plays a vital role in cellular responses to extracellular pH and ion homeostasis. Despite its significance, the mechanisms by which GPR30 interacts with bicarbonate ions remain elusive.
Shota Kaneda, Airi Jo-Watanabe, Hiroaki Akasaka, Hidetaka S Oshima, Takehiko Yokomizo, Wataru Shihoya, Osamu Nureki   +6 more
doaj   +2 more sources

Interaction Between CCL18 and GPR30 Differs from the Interaction Between Estradiol and GPR30 [PDF]

Anticancer Research, 2020
C-C motif chemokine ligand 18 (CCL18) is overexpressed in the microenvironment of tumors, promotes invasion and metastasis and is thus important for the therapeutic outcome of many tumor entities. The Gs-coupled seven-transmembrane receptor GPR30 is known as both a CCL18 and an estrogen receptor; its activation by estradiol leads to a transactivation ...
Schmidt-Wolf, Roland, Zissel, Gernot
openaire   +3 more sources

Transcription factor Krüppel‐like factor 4 upregulated G protein‐coupled receptor 30 alleviates intestinal inflammation and apoptosis, and protects intestinal integrity from intestinal ischemia–reperfusion injury

Immunity, Inflammation and Disease, 2023
Introduction Intestinal ischemia/reperfusion (I/R) injury is a common clinical event occurring during multiple clinical pathological processes. Here, we designed this paper to discuss the role of G protein‐coupled receptor 30 (GPR30) playing in ...
Jie Yin, Xiaoli Xie, Jinfeng Yao, Xiaoxu Jin, Huiqing Jiang, Chenguang Ji   +5 more
doaj   +1 more source

In vivo effects of a GPR30 antagonist [PDF]

Nature Chemical Biology, 2009
Estrogen is central to many physiological processes throughout the human body. We have previously shown that the G protein-coupled receptor GPR30 (also known as GPER), in addition to classical nuclear estrogen receptors (ER and ER), activates cellular signaling pathways in response to estrogen.
Dennis, Megan K., Burai, Ritwik, Ramesh, Chinnasamy, Petrie, Whitney K., Alcon, Sara N., Nayak, Tapan K., Bologa, Cristian G., Leitao, Andrei, Brailoiu, Eugen, Deliu, Elena, Dun, Nae J., Sklar, Larry A., Hathaway, Helen J., Arterburn, Jeffrey B., Oprea, Tudor I., Prossnitz, Eric R.   +15 more
openaire   +2 more sources

Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor α (ERα). [PDF]

PLoS ONE, 2013
Estrogens and tamoxifen (an antiestrogen) exert their actions by activation of estrogen receptor (ER) through genomic and non-genomic mechanisms and are implicated in the development of endometrial cancer.
Chia-Lung Tsai, Hsien-Ming Wu, Chiao-Yun Lin, Yi-Jun Lin, Angel Chao, Tzu-Hao Wang, Swei Hsueh, Chyong-Huey Lai, Hsin-Shih Wang   +8 more
doaj   +1 more source

Inhibition of GPR30 sensitized gefitinib to NSCLC cells via regulation of epithelial-mesenchymal transition

International Journal of Immunopathology and Pharmacology, 2023
Introduction: G-protein coupled receptor 30 (GPR30) is associated with cell metastasis and drug resistance in many different cancer cells. The present study aimed to reveal the sensitivity of GPR30 to gefitinib in non-small cell lung cancer (NSCLC) cells.
Xiaomin Yang, Hongyan Jiang, Jiang Ning, Shufen Zhang, Ying Cai, Liang Wang, Jinsong Yang, Guodong Xu, Wei Chen, Jianfei Wang   +9 more
doaj   +1 more source

GPR30 Contributes to Estrogen-Induced Thymic Atrophy [PDF]

Molecular Endocrinology, 2008
The mechanisms by which prolonged estrogen exposures, such as estrogen therapy and pregnancy, reduce thymus weight, cellularity, and CD4 and CD8 phenotype expression, have not been well defined. In this study, the roles played by the membrane estrogen receptor, G protein-coupled receptor 30 (GPR30), and the intracellular estrogen receptors, estrogen ...
Chunhe, Wang, Babak, Dehghani, I Jack, Magrisso, Elizabeth A, Rick, Edna, Bonhomme, David B, Cody, Laura A, Elenich, Sandhya, Subramanian, Stephanie J, Murphy, Martin J, Kelly, Jan S, Rosenbaum, Arthur A, Vandenbark, Halina, Offner   +12 more
openaire   +2 more sources

Estrogen-mediated renoprotection following cardiac arrest and cardiopulmonary resuscitation is robust to GPR30 gene deletion. [PDF]

PLoS ONE, 2014
IntroductionAcute kidney injury is a serious,sexually dimorphic perioperative complication, primarily attributed to hypoperfusion. We previously found that estradiol is renoprotective after cardiac arrest and cardiopulmonary resuscitation in ...
Michael P Hutchens, Yasuharu Kosaka, Wenri Zhang, Tetsuhiro Fujiyoshi, Stephanie Murphy, Nabil Alkayed, Sharon Anderson   +6 more
doaj   +1 more source

G-protein coupled receptor 30 (GPR30): a novel regulator of endothelial inflammation. [PDF]

PLoS ONE, 2012
Estrogen, the female sex hormone, is known to exert anti-inflammatory and anti-atherogenic effects. Traditionally, estrogen effects were believed to be largely mediated through the classical estrogen receptors (ERs). However, there is increasing evidence
Subhadeep Chakrabarti, Sandra T Davidge
doaj   +1 more source

Activation of GPR30 inhibits cardiac fibroblast proliferation [PDF]

Molecular and Cellular Biochemistry, 2015
The incidence of left ventricular diastolic dysfunction significantly increases in postmenopausal women suggesting the association between estrogen loss and diastolic dysfunction. The in vivo activation of G protein-coupled estrogen receptor (GPR30) attenuates the adverse effects of estrogen loss on cardiac fibrosis and diastolic dysfunction in mRen2 ...
Hao, Wang, Zhuo, Zhao, Marina, Lin, Leanne, Groban   +3 more
openaire   +2 more sources