Results 11 to 20 of about 22,632 (211)

Estrogen Replacement Therapy in Ovariectomized Rats: Complementary Roles of ER and GPR30 in Alleviating Depressive-like Behavior [PDF]

Current Issues in Molecular Biology
Women are twice as likely to suffer from major depressive disorder (MDD). The underlying mechanism between estrogen and depression is still unknown. We used ovariectomized rats to simulate menopausal status and established a depression model of chronic ...
Siyi He, Zhongyu Ren, Lan Wu, Yinping Xie, Limin Sun, Ling Xiao, Gaohua Wang   +6 more
doaj   +2 more sources

Detection of the Phosphorylation of the Estrogen Receptor α as an Outcome of GPR30 Activation [PDF]

, 2016
Phosphorylation of the serine residues in estrogen receptor (ER) α is important in transcriptional activation. Hence, methods to detect such posttranslational modification events are valuable. We describe, in detail, the analysis of the phosphorylated ERα by electrophoretic separation of proteins and subsequent immuno-blotting techniques. In particular,
Clark, Sara, Pollard, Kevin, Rainville, Jennifer, Vasudevan, Nandini   +3 more
openaire   +4 more sources

G Protein-Coupled Receptor 30 Attenuates Neuronal Pyroptosis Induced by Subarachnoid Hemorrhage [PDF]

Mediators of Inflammation
Conclusion: GPR30 mitigates NLRC4- and IFI16-driven neuronal pyroptosis in SAH by modulating TLR4/NF-κB signaling. Pharmacological targeting of GPR30 represents a promising therapeutic strategy to ameliorate SAH-associated brain injury.
Jun Peng, Xiqi Hu, Jun He, Ying Xia
doaj   +2 more sources

Joint Inflammation Correlates with Joint GPR30 Expression in Males and Hippocampal GPR30 Expression in Females in a Rat Model of Rheumatoid Arthritis. [PDF]

Int J Mol Sci
It is not entirely clear how the interaction between joint inflammation and the central nervous system (CNS) response in rheumatoid arthritis (RA) works, and what pathophysiology underlies the sex differences in coexisting neuropsychiatric comorbidities.
Grubić Kezele T, Omrčen H, Batičić L, Šućurović S, Zoričić Cvek S.   +4 more
europepmc   +4 more sources

GPR30-mediated NETs degradation via Trex1 in heart failure of aged female mice [PDF]

Journal of Translational Medicine
Background The occurrence of cardiovascular diseases increases dramatically in postmenopausal aged women. Accumulating evidence has indicated that estrogen protects hearts from cardiovascular diseases.
Shuaishuai Zhang, Zilin Li, Xiaoya Wang, Xiaowu Wang, Jun Du, Jiaqi Liu, Zhirong Cheng, Diancai Zhao, Weixun Duan, Jipeng Ma, Jincheng Liu   +10 more
doaj   +2 more sources

Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury [PDF]

Nature Communications
Homoeostatic regulation of the acid–base balance is essential for cellular functional integrity. However, little is known about the molecular mechanism through which the acid–base balance regulates cellular responses.
Airi Jo-Watanabe, Toshiki Inaba, Takahiro Osada, Ryota Hashimoto, Tomohiro Nishizawa, Toshiaki Okuno, Sayoko Ihara, Kazushige Touhara, Nobutaka Hattori, Masatsugu Oh-Hora, Osamu Nureki, Takehiko Yokomizo   +11 more
doaj   +2 more sources

Cardiovascular β-Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue. [PDF]

Compr Physiol
Estrogen modulates β‐AR signaling in a context‐dependent manner influenced by species, sex, age, tissue, and vascular health, highlighting challenges in translating findings from experimental models to human cardiovascular physiology. ABSTRACT Cardiovascular diseases remain the leading global cause of morbidity and mortality, with notable sex‐specific ...
Elsaid B, Kopaliani I, Zatschler B, Seif A, Speier S, Deussen A.   +5 more
europepmc   +2 more sources

Interaction Between CCL18 and GPR30 Differs from the Interaction Between Estradiol and GPR30 [PDF]

Anticancer Research, 2020
C-C motif chemokine ligand 18 (CCL18) is overexpressed in the microenvironment of tumors, promotes invasion and metastasis and is thus important for the therapeutic outcome of many tumor entities. The Gs-coupled seven-transmembrane receptor GPR30 is known as both a CCL18 and an estrogen receptor; its activation by estradiol leads to a transactivation ...
Schmidt-Wolf, Roland, Zissel, Gernot
openaire   +3 more sources

Disruption of 3D MCF-12A breast cell cultures by estrogens - An in vitro model for ER-mediated changes indicative of hormonal carcinogenesis [PDF]

, 2012
Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and 85 reproduction in any medium, provided the original author and source
Elisabete Silva, Irina Agoulnik, Stephanie Marchese   +2 more
core   +10 more sources

Transcription factor Krüppel‐like factor 4 upregulated G protein‐coupled receptor 30 alleviates intestinal inflammation and apoptosis, and protects intestinal integrity from intestinal ischemia–reperfusion injury

Immunity, Inflammation and Disease, 2023
Introduction Intestinal ischemia/reperfusion (I/R) injury is a common clinical event occurring during multiple clinical pathological processes. Here, we designed this paper to discuss the role of G protein‐coupled receptor 30 (GPR30) playing in ...
Jie Yin, Xiaoli Xie, Jinfeng Yao, Xiaoxu Jin, Huiqing Jiang, Chenguang Ji   +5 more
doaj   +1 more source