Results 21 to 30 of about 19,033 (167)

The Interactions Between GPR30 and the Major Biomarkers in Infiltrating Ductal Carcinoma of the Breast in an Asian Population

Taiwanese Journal of Obstetrics & Gynecology, 2007
Objective: G-protein-coupled receptor 30 (GPR30) has been reported to be a novel estrogen receptor a (ERa) in vitro. Therefore, the interactions among GPR30, ERa, progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2/neu), and ...
Wen-Hung Kuo, Li-Yun Chang, Daisy Li-Yu Liu, Hsiao-Lin Hwa, Jen-Jen Lin, Po-Huang Lee, Chiung-Nien Chen, Huang-Chun Lien, Ray-Hwang Yuan, Chia-Tung Shun, King-Jen Chang, Fon-Jou Hsieh   +11 more
doaj   +1 more source

Joint Inflammation Correlates with Joint GPR30 Expression in Males and Hippocampal GPR30 Expression in Females in a Rat Model of Rheumatoid Arthritis. [PDF]

Int J Mol Sci
It is not entirely clear how the interaction between joint inflammation and the central nervous system (CNS) response in rheumatoid arthritis (RA) works, and what pathophysiology underlies the sex differences in coexisting neuropsychiatric comorbidities.
Grubić Kezele T, Omrčen H, Batičić L, Šućurović S, Zoričić Cvek S.   +4 more
europepmc   +5 more sources

Novel G Protein-Coupled Oestrogen Receptor GPR30 Shows Changes in mRNA Expression in the Rat Brain over the Oestrous Cycle

Neurosignals, 2012
Oestrogen influences autonomic function via actions at classical nuclear oestrogen receptors α and β in the brain, and recent evidence suggests the orphan G protein-coupled receptor GPR30 may also function as a cytoplasmic oestrogen receptor.
Emma J. Spary, Sally E. Chapman, John K. Sinfield, Azhar Maqbool, Jean Kaye, Trevor F.C. Batten   +5 more
doaj   +1 more source

Plasma membrane expression of G protein-coupled estrogen receptor (GPER)/G protein-coupled receptor 30 (GPR30) is associated with worse outcome in metachronous contralateral breast cancer.

PLoS ONE, 2020
BACKGROUND:G protein-coupled estrogen receptor (GPER), or G protein-coupled receptor 30 (GPR30), is reported to mediate non-genomic estrogen signaling. GPR30 associates with breast cancer (BC) outcome and may contribute to tamoxifen resistance.
Julia Tutzauer, Martin Sjöström, Pär-Ola Bendahl, Lisa Rydén, Mårten Fernö, L M Fredrik Leeb-Lundberg, Sara Alkner   +6 more
doaj   +1 more source

Ginsenoside Rg1 Prevents Cognitive Impairment and Hippocampal Neuronal Apoptosis in Experimental Vascular Dementia Mice by Promoting GPR30 Expression

Neural Plasticity, 2021
This study is aimed at investigating the potential roles of G protein-coupled estrogen receptor 1 (GPER, also known as GPR30) in the preventive effect of ginsenoside Rg1 against cognitive impairment and hippocampal cell apoptosis in experimental vascular
Fengming Shen, Juan Wang, Feng Gao, Jingji Wang, Guoqi Zhu   +4 more
doaj   +1 more source

Pregnancy Achievement by Medical Assisted Reproduction Is Correlated to the G Protein-Coupled Receptor 30 mRNA Abundance in Human Spermatozoa

Applied Sciences, 2022
Estrogens, specifically 17β-estradiol (E2), play an important role in male health, including male fertility. The G protein-coupled receptor for estrogen 30 (GPR30) is essential for mediating the rapid non-genomic effects of E2 on a variety of testicular ...
Sara C. Pereira, Inês F. Esperança, Soraia Pinto, Alberto Barros, Mário Sousa, Marco G. Alves, Pedro F. Oliveira   +6 more
doaj   +1 more source

GPR30 regulates the EGFR-Akt cascade and predicts lower survival in patients with ovarian cancer

Journal of Ovarian Research, 2012
Objectives G protein-coupled receptor 30 (GPR30) is a 7-transmembrane estrogen receptor that functions alongside traditional estrogen receptors to regulate the cellular responses to estrogen.
Fujiwara Satoe, Terai Yoshito, Kawaguchi Hiroshi, Takai Masaaki, Yoo Saha, Tanaka Yoshimichi, Tanaka Tomohito, Tsunetoh Satoshi, Sasaki Hiroshi, Kanemura Masanori, Tanabe Akiko, Yamashita Yoshiki, Ohmichi Masahide   +12 more
doaj   +1 more source

PJA1 mediates the effects of astrocytic GPR30 on learning and memory in female mice

The Journal of Clinical Investigation, 2023
Hormone replacement therapy (HRT) is not recommended for treating learning and memory decline in menopausal women because it exerts adverse effects by activating classic estrogen receptors ERα and ERβ.
Xinshang Wang, Yongli Jiang, Ban Feng, Xue Ma, Kun Zhang, Fan Yang, Zhenguo Liu, Le Yang, Jiao Yue, Liang Lu, Dake Song, Qingjuan Guo, Jingyu Qi, Xubo Li, Min Wang, Huinan Zhang, Jing Huang, Minggao Zhao, Shuibing Liu   +18 more
doaj   +1 more source

GPER and Testicular Germ Cell Cancer

Frontiers in Endocrinology, 2021
The G protein-coupled estrogen receptor (GPER), also known as GPR30, is a widely conserved 7-transmembrane-domain protein which has been identified as a novel 17β-estradiol-binding protein that is structurally distinct from the classic oestrogen ...
Nicolas Chevalier, Nicolas Chevalier, Charlotte Hinault, Charlotte Hinault, Stephan Clavel, Rachel Paul-Bellon, Patrick Fenichel, Patrick Fenichel   +7 more
doaj   +1 more source

The Correlation between GPR30 and Clinicopathologic Variables in Breast Carcinomas [PDF]

Technology in Cancer Research & Treatment, 2009
The G-protein-coupled-receptor 30 (GPR30) is a new membrane estrogen receptor. The aim of the present study was to determine the correlations among GPR30, ERα, PR, C-erbB-2, p53, TNM stage, and pathologic grade in breast carcinomas. Two hundred forty-one biopsy specimens were evaluated with immunohistochemical assays, and then correlations were ...
G, Tu, D, Hu, G, Yang, T, Yu
openaire   +2 more sources