Results 61 to 70 of about 94,252 (292)

The Research Advances in G-Protein-Coupled Estrogen Receptor

, 2023
Estrogen binds to the typical estrogen receptor (ER) ERα or ERβ and is translocated to the nucleus, where it binds directly to the estrogen response element of the target gene to induce transcription and regulate gene expression, and the whole process is completed in several hours to several days.
Hong-Bing Zhang, Yao Wang, Bing Wang
openaire   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Does GPER Really Function as a G Protein-Coupled Estrogen Receptor in vivo?

Frontiers in Endocrinology, 2020
Estrogen can elicit pleiotropic cellular responses via a diversity of estrogen receptors (ERs)—mediated genomic and rapid non-genomic mechanisms. Unlike the genomic responses, where the classical nuclear ERα and ERβ act as transcriptional factors ...
Jing Luo, Jing Luo, Dongmin Liu
doaj   +1 more source

Physiopathological Implications of 7TM Receptors [PDF]

, 2010
Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways.
Cygankiewicz, Adam
core   +2 more sources

Estrogen Receptor Beta and G‐Protein Coupled Estrogen Receptor are Located and Activated on Microglia by Estrogen

The FASEB Journal, 2018
Upon menopause, women have an increased risk of cardiovascular disease, in part due to the decrease in estrogen production that occurs. While estrogen's cardioprotective effects have been known for many years, the exact mechanism of this protection is still under investigation.
Katherine Dvorak, Michael Boyer, Maria J. Barnes, Sarah C. Clayton   +3 more
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study. [PDF]

, 2016
Gonadotropin-releasing hormone (GnRH) neurons are controlled by 17beta-estradiol (E2) contributing to the steroid feedback regulation of the reproductive axis.
Bálint, Flóra, Farkas, Imre, Liposits, Zsolt   +2 more
core   +1 more source

G Protein–Coupled Estrogen Receptor Regulates Mammary Tumorigenesis and Metastasis [PDF]

Molecular Cancer Research, 2014
AbstractThe role of 17β-estradiol (E2) in breast cancer development and tumor growth has traditionally been attributed exclusively to the activation of estrogen receptor-α (ERα). Although targeted inhibition of ERα is a successful approach for patients with ERα+ breast cancer, many patients fail to respond or become resistant to anti-estrogen therapy ...
Nicole A, Marjon, Chelin, Hu, Helen J, Hathaway, Eric R, Prossnitz   +3 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Estradiol meets Notch signaling in developing neurons

Frontiers in Endocrinology, 2011
The transmembrane receptor Notch, a master developmental regulator, controls gliogenesis, neurogenesis and neurite development in the nervous system.
Maria-Angeles eArevalo, Isabel eRuiz-Palmero, Julia eSimon-Areces, Estefania eAcaz-Fonseca, Iñigo eAzcoitia, Luis Miguel Garcia-Segura   +5 more
doaj   +1 more source